The Kentucky Wildcats (5-5, 2-5 SEC) take on the Vanderbilt Commodores (8-2, 4-2 SEC) in Nashville, Tennessee. Kickoff is set for 3:30 p.m. EST on ESPN.
Vanderbilt is favored by 8.5 points on the spread with a moneyline of -355. The total is set at 54.5 points.
Here’s my Kentucky vs. Vanderbilt prediction and college football picks for Saturday, November 22, 2025.
Kentucky Wildcats vs Vanderbilt Commodores Prediction, Picks
- Kentucky vs. Vanderbilt Pick: Kentucky +10 or Better
Kentucky vs Vanderbilt Odds, Spread, Line
| Kentucky Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+7 -108 | 53.5 -112o / -108u | +230 |
| Vanderbilt Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-7 -112 | 53.5 -112o / -108u | -290 |
- Kentucky vs Vanderbilt Spread: Vanderbilt -7, Kentucky +7
- Kentucky vs Vanderbilt Over/Under: 53.5
- Kentucky vs Vanderbilt Moneyline: Kentucky +230, Vanderbilt -290
Kentucky vs Vanderbilt NCAAF Pick to Bet
I project Vanderbilt as a 10-point favorite.
But I think this game is going to be a brawl.
Kentucky won’t allow any explosives, and Vanderbilt isn’t trying to create explosives.
Instead, the Commodores are going to be extremely methodical on offense.
The key to this game is whether Kentucky can defend the counter and man rush concepts that Diego Pavia and the Commodores run. The Wildcats absolutely can do that.
This game is a grind, and you should take as many points as you can get. I would love +10 with Kentucky, but I need double-digits to back the 'Cats.
Pick: Kentucky +10 or Better
Moneyline
No interest; PASS.
Against the Spread
Back the Wildcats at +10 or Better.
Over/Under
No interest; PASS.
