The Clemson Tigers take on the SMU Mustangs in Dallas, Texas. Tip-off is set for 4 p.m. ET on ACC Network.
Clemson is favored by 1.5 points on the spread with a moneyline of -122. The total is set at 145.5 points.
Here are my Clemson vs. SMU predictions and college basketball picks for February 22, 2025.
Clemson vs SMU Prediction
My Pick: SMU +1.5 (Depending on Boopie Miller's Health)
My Clemson vs SMU best bet is on the Mustangs spread, with the best odds currently available at bet365. For all of your college basketball bets, be sure to find the best lines by using our live NCAAB odds page.
Clemson vs SMU Odds
| Clemson Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -115 | 145.5 -108o / -112u | -122 |
| SMU Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -105 | 145.5 -108o / -112u | +102 |
- Clemson vs SMU spread: Clemson -1.5 (-115), SMU +1.5 (-105)
- Clemson vs SMU over/under: 145.5 (-108o / -112u)
- Clemson vs SMU moneyline: Clemson -122, SMU +102
- Clemson vs SMU best bet: SMU +1.5 (Depending on Miller's Health)
Spread
I'm taking the Mustangs on the spread, as this is a good spot for them.
Moneyline
I'm avoiding the moneyline.
Over/Under
I have no play on the total.
My Pick: SMU +1.5 (Depending on Miller's Health)
Clemson vs SMU College Basketball Betting Preview
Editor's Note: Boopie Miller is out against Clemson.
We'll see how healthy SMU is, but I like the Mustangs in this spot, as this is essentially an NCAA Tournament game for them.
If the Mustangs lose to the Tigers, it's unlikely they reach the Big Dance. And if they win, they just have to avoid a bad loss down the stretch.
Andy Enfield's squad is 5-2 in Quad 2 games, but it has yet to win a Quad 1 game this season (0-4), losing to Mississippi State, Duke, North Carolina and Louisville.
If you look at SMU from a pure metrics perspective, it should already be in the Big Dance. But that Quad 4 record — and the fact that they have zero wins versus the likely at-large field — is holding it back at this moment.
I don't know if Boopie Miller, who missed SMU's game earlier this week against Notre Dame with a foot injury, is going to play. He was a gametime decision for that outing, so I expect him to suit up.
SMU wants to live on the offensive glass (39th nationally in offensive boards per game), and that's exactly what you can do against Clemson (223rd nationally in offensive boards allowed per game).
Also, the Mustangs are solid in the mid-range, which is another area you need to capitalize against the Tigers.
With its very compact defense, Enfield's unit isn't going to allow the Tigers to operate in the post with Ian Schieffelin or Viktor Lakhin.
My one concern is that the Mustangs have been getting lucky defensively when it comes to the 3-ball and Clemson can shoot.
However, Clemson may be fat and happy here. The Tigers have an easy schedule remaining, they've already beaten Duke and they're already in the NCAA Tournament.
This is a good spot for SMU, depending on Miller's health.
