The Milwaukee Brewers host the St. Louis Cardinals on May 25, 2026. First pitch from American Family Field is scheduled for 2:10 p.m. EDT. The game will be broadcast on BREW.
The Brewers are favored by -220 on the moneyline and by -1.5 on the run line. The Cardinals are +184 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.
Find our MLB picks and Cardinals vs Brewers prediction below, as well as probable pitchers, weather report, and more.
Cardinals vs Brewers Prediction
- Cardinals vs Brewers Pick: Under 7.5 (-105)
Our Cardinals vs Brewers best bet is on the under total runs. Make sure to find the best odds by checking our live MLB odds page.
Cardinals vs Brewers Odds
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -118 | 7.5 -115o / -105u | +184 |
| Brewers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -102 | 7.5 -115o / -105u | -220 |
- Cardinals vs Brewers moneyline: Cardinals +184, Brewers -220
- Cardinals vs Brewers over/under: 7.5 (-115o / -105u)
- Cardinals vs Brewers spread: Brewers -1.5 (-102), Cardinals +1.5 (-118)
Cardinals vs Brewers Probable Pitchers
| LHP Matthew Liberatore (STL) | Stat | RHP Jacob Misiorowski (MIL) |
|---|---|---|
| 2-2 | W-L | 4-2 |
| 0.1 | fWAR (FanGraphs) | 2.2 |
| 4.70/5.64 | ERA / xERA | 1.89/2.30 |
| 4.84/4.24 | FIP / xFIP | 2.12/2.20 |
| 10.2% | K-BB% | 31.2% |
| 37.7% | GB% | 43.4% |
| .331 | BABIP | .257 |
| 98 | Stuff+ | 125 |
| 101 | Location+ | 99 |
Cardinals vs Brewers MLB Betting Preview
The Milwaukee Brewers welcome the St. Louis Cardinals to American Family Field this Monday for the start of a pivotal three-game series.
Both squads enter this matchup in the upper echelon of the NL Central, with the Brewers holding a slim lead for the top spot.
Milwaukee has been particularly formidable at home, boasting a 16-11 record in their own ballpark, while the Cardinals have proved to be dangerous travelers with a strong 16-9 road record.
This contest features a fascinating discrepancy in the pitching matchup. The Brewers will hand the ball to Jacob Misiorowski, who has evolved into a legitimate ace this season.
Misiorowski leads the National League with 88 strikeouts and arrives at this Memorial Day start on the heels of a dominant 24 1/3-inning scoreless streak.
On the other side, St. Louis counters with Matthew Liberatore. While his season stats are more modest—carrying a 4.70 ERA and a 1.55 WHIP—he has historically owned the Brewers.
Liberatore’s 1.26 career ERA against Milwaukee is his lowest against any opponent he has faced in at least 10 appearances.
Cardinals vs Brewers Pick, Betting Analysis
The strategic play for this Memorial Day matinee is the Under 7.5 runs. This recommendation is heavily supported by the "PRO: Contrarian Unders for Winning Teams" system developed by Evan Abrams.
The logic behind this system is that when two winning teams face off, the betting public often expects an offensive explosion, typically leading to low betting volume on the under.
However, these high-stakes matchups between top-tier teams usually result in tighter execution, superior bullpen management, and "playoff-style" baseball where runs are at a premium.
Beyond the system's historical edge, the specific pitching dynamics reinforce the low-scoring outlook.
You have Jacob Misiorowski in the midst of a historic scoreless stretch and a high-strikeout rhythm that can neutralize even the most potent lineups.
Conversely, Matthew Liberatore’s strange mastery over the Brewers' bats suggests he will over-perform his season averages in this specific environment.
With Milwaukee's recent 2.83 team ERA and both clubs possessing winning percentages well above .500, the market's inflated total offers a prime opportunity to bet against the public consensus.
Pick: Under 7.5 (-105)
