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Giants vs Athletics Prediction, Pick, MLB Odds for Saturday, May 16

Giants vs Athletics Prediction, Pick, MLB Odds for Saturday, May 16 article feature image
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May 11, 2026; Los Angeles, California, USA; San Francisco Giants starting pitcher Trevor McDonald (72) delivers a pitch in the first inning against against the Los Angeles Dodgers at Dodger Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

The Athletics host the San Francisco Giants on May 16, 2026. First pitch from Sutter Health Park is scheduled for 9:40 p.m. EDT. The game will be broadcast on NBCS-CA.

The Athletics are favored by -134 on the moneyline and by -1.5 on the run line. The Giants are +114 on the moneyline and +1.5 on the run line. The total is set at 9.5 runs.

Find my MLB picks and Giants vs Athletics prediction below, as well as probable pitchers, weather report, and more.


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Giants vs Athletics Prediction

  • Giants vs Athletics Pick: Trevor McDonald Under 4.5 Strikeouts (-128 or Better)

Giants vs Athletics Odds

Giants Logo
Saturday, May 16
9:40 p.m. ET
NBCS-CA
Athletics Logo
Giants Odds
SpreadTotalMoneyline
+1.5
-178
9.5
-122o / -100u
+114
Athletics Odds
SpreadTotalMoneyline
-1.5
+146
9.5
-122o / -100u
-134
Odds via FanDuel. Get up-to-the-minute MLB odds here.
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Giants vs Athletics Polymarket Odds

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Giants vs Athletics Probable Pitchers

Trevor McDonald (RHP, SFG)StatLuis Severino (RHP, ATH)
1-0W-L2-4
0.1fWAR (FanGraphs)0.5
2.92 / 3.71ERA / xERA4.07 / 4.57
3.99 / 2.57FIP / xFIP4.41 / 4.46
20.0%K-BB%8.5%
68.6%GB%43.5%
.273BABIP.313
101Stuff+108
104Location+100

Giants vs Athletics MLB Betting Preview

Written by Derek Carty of THE BAT X.

Love THE BAT X? Get all of Carty's sports betting projections at EV Analytics!


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Giants vs Athletics Pick, Betting Analysis

THE BAT X forecasts 4.07 strikeouts for Trevor McDonald, compared to the 4.75 strikeouts implied by the oddsmakers, so I believe there is value on this prop.

If you take the Under, you'd be projected to win 62% of the time, resulting in a 27% ROI.

Based on a $100 wager, the expected value here would be $27.31.

This play is good down to at least -128.

Pick: Trevor McDonald Under 4.5 Strikeouts (-128 or Better)


Giants vs Athletics Weather


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