The Minnesota Twins host the Cincinnati Reds on April 17, 2026. First pitch from Target Field is scheduled for 8:10 p.m. EDT. The game will be broadcast on MNNT.
The Twins are favored by -180 on the moneyline and by -1.5 on the run line. The Reds are +145 on the moneyline and +1.5 on the run line. The total is set at 8 runs.
Find my MLB picks and Reds vs Twins prediction below, as well as probable pitchers, weather report, and more.
Reds vs Twins Prediction
- Reds vs Twins Pick: Cincinnati Reds +145
My Reds vs Twins best bet is on the Cincinnati Moneyline. Make sure to find the best odds by checking our live MLB odds page.
Reds vs Twins Odds
| Reds Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 +122 | 8 -102o / -115u | +145 |
| Twins Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -148 | 8 -102o / -115u | -180 |
- Reds vs Twins moneyline: Reds +145, Twins -180
- Reds vs Twins over/under: 8 (-102o / -115u)
- Reds vs Twins spread: Twins -1.5 (+122 ), Reds +1.5 (-148)
Reds vs Twins Probable Pitchers
| LHP Brandon Williamson (CIN) | Stat | RHP Joe Ryan (MIN) |
|---|---|---|
| 1-1 | W-L | 2-1 |
| -0.1 | fWAR (FanGraphs) | 0.6 |
| 5.28/7.42 | ERA / xERA | 3.80/2.55 |
| 6.36/5.89 | FIP / xFIP | 2.84/4.04 |
| 1.37 | WHIP | 0.98 |
| 1.5% | K-BB% | 18.8% |
| 29.8% | GB% | 31.5% |
| 98 | Stuff+ | 107 |
| 93 | Location+ | 107 |
Reds vs Twins MLB Betting Preview
The main narrative at Target Field tonight is the "homecoming" for Reds southpaw Brandon Williamson (1-1, 5.28 ERA).
The Fairmont, Minnesota native makes his first career start against his childhood team. While Williamson's ERA is inflated following six walks in his outing against the Los Angeles Angels, he has shown an ability to navigate high-leverage situations.
He'll be backed by a Reds offense led by rookie sensation Sal Stewart, who has exploded onto the scene with seven home runs and a 1.094 OPS in the early going.
On the other side, the Twins turn to Joe Ryan (2-1, 3.80 ERA). Ryan has been a model of efficiency this season, most recently dismantling the Blue Jays over seven innings. However, the Twins’ "potent offense" —currently second in the American League in home runs— stalled in their last outing against Boston.
While the Twins enter as the heavy favorites, they face a Cincinnati team that has been surprisingly resilient on the road this year, posting a 5-2 record away from Great American Ball Park.
Reds vs Twins Pick, Betting Analysis
Our Bet Labs "Road Dogs Interleague" system has identified a significant edge on the Cincinnati moneyline.
In Major League Baseball, road underdogs playing interleague (non-conference) games have historically been undervalued by oddsmakers. Since 2016, despite winning only 43.3% of these games, these teams have generated a consistent positive ROI of 4.6%.
This trend has proven reliable across five consecutive seasons, indicating market inefficiencies in how these specific matchups are priced—likely due to lack of familiarity between leagues and public overconfidence in home and favorite teams. In interleague play, road underdogs have been profitable on the money line recently. They have only a 43.3% win percentage, but those teams have turned a 4.6% ROI for bettors since 2016 and have been profitable in five consecutive seasons.
Joe Ryan has only one career start against Cincinnati (back in 2023), and Williamson has never faced the Twins. This "information gap" typically favors the underdog, as pitchers often hold the upper hand when hitters haven't seen their release points or movement patterns in person.
The Twins are priced as -180 favorites, largely due to their home-field advantage and high-octane offense. However, the Reds have actually been more profitable on the moneyline this season (+3.3 units).
At +145, the implied probability of a Reds win is roughly 40.8%. Given that the "Road Dogs Interleague" system wins at a 43.3% clip, we are gaining a mathematical edge over the house.
Pick: Cincinnati Reds +145
