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Yankees vs Twins Prediction, Pick, Odds for Wednesday, September 17

Yankees vs Twins Prediction, Pick, Odds for Wednesday, September 17 article feature image
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Photo Credit: Jesse Johnson-Imagn Images. Pictured: Jazz Chisholm

The Minnesota Twins host the New York Yankees on September 17, 2025. First pitch from Target Field is scheduled for 7:40 p.m. EDT; the game will be broadcast on MNNT.

Find my MLB betting preview and Yankees vs Twins prediction below, as well as probable pitchers, betting trends, injury reports and more.

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My Yankees vs Twins Prediction

  • Yankees vs Twins picks: Jazz Chisholm Home Run (+520)

My Yankees vs Twins best bet is for Jazz Chisholm to homer (+520). Make sure to find the best odds by checking our live MLB odds page.


Yankees vs Twins Odds

Yankees Logo
September 17, 2025
7:40 p.m. EDT
MNNT
Twins Logo
Yankees Odds
SpreadTotalMoneyline
-1.5
-124
9
-118o / -104u
-156
Twins Odds
SpreadTotalMoneyline
+1.5
+102
9
-118o / -104u
+131
Odds via bet365. Get up-to-the-minute MLB odds here.
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Alex Kolodziej’s Yankees vs Twins Prediction, Betting Preview

Last night, PRO Projections accurately predicted a home run from Trent Grisham in the Yankees vs. Twins game

Looking ahead to tonight’s matchup between the Yankees and Twins, another left-handed hitter sticks out with value when comparing our probabilities to today’s odds. Our top pick for Wednesday’s game is Jazz Chisholm, who is priced at enticing +520 odds.

According to PRO Projections, Chisholm is expected to hit approximately 0.23 home runs in Wednesday’s game at Target Field. This suggests that the fair betting price should be closer to +335, and PRO lists a +4.4% edge for bettors tailing Chisholm to bash one out of the park.

Chisholm has had a remarkable season, smashing 29 home runs over 119 games. For context, his previous high was 24 homers. Target Field is an obvious downgrade from Yankee Stadium in terms of park factor, but it’s still an opportune time of the season to be hitting in the park.

A day after calling Grisham to homer, PRO Projections recommend Jazz Chisholm as the best value pick to homer in tonight's Yankees vs. Twins game.



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About the Author

Alex began his career as a freelancer before becoming a columnist, reporter, and breaking news writer for FanRag Sports, and later the leading gambling writer at theScore. He joined the Action Network as a senior news editor, handling breaking news and the sports betting market's reactions. Alex also works on Action Network’s PRO projections, transforming subscription-based models into user-friendly content.

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