The MLB regular season is back in action with an excellent 15-game slate on Wednesday, featuring several daytime ballgames.
Our staff of MLB experts has locked in three moneyling picks across three contests, including bets for Braves vs. Athletics and Dodgers vs. Guardians.
Let's get to our MLB predictions, picks and expert bets for Wednesday, April 1.
MLB Picks, Predictions for Wednesday, April 1
The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Game | Time (ET) | Pick |
|---|---|---|
  | 12:15 PM | |
  | 4:10 PM | |
  | 8:20 PM | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
Athletics vs. Braves Moneyline Picks
By Sean Paul
I like the A's at the plus-money price.
Chris Sale is better than Luis Severino by a good bit. Still, I like Severino and think he's worth backing as a heavy road pup.
The Athletics lineup should be able to hit southpaws. Brent Rooker, Jacob Wilson, and Shea Langeliers have a strong history of hitting lefties.
Of course, we'll see if that carries into this matchup against a Cy Young candidate.
Still, I think the price is too steep on the Braves, who haven't looked great so far. The three best hitters in the lineup have struggled, and Wednesday feels like a good time to fade them.
Check out Paul's full Athletics-Braves breakdown here:
Pick: Athletics ML (+130 or Better)
| | |
Yankees vs. Mariners Moneyline Predictions
Cam Schlitter vs. George Kirby is must-watch television, just like Max Fried vs. Logan Gilbert.
Schlitter is the young, breakout star, while Kirby is the established veteran ace who might have another elite tier to reach.
Schlitter dominated the Giants in his first start of the season. He pitched 5 1/3 innings, allowing zero runs, zero walks, just one hit, while striking out eight batters. This follows a 2025 season with a 2.96 ERA through 73 regular-season innings.
Meanwhile, Kirby posted a typical start last week. Through six innings, he allowed two hits, two walks, and one earned run while striking out six.
Both Kirby (vs. Guardians) and Schlittler (vs. Giants) faced mediocre offenses in their first start. However, we have an extended sample of Kirby's success. He is a perennial AL Cy Young candidate who is deservedly in the conversation for the league's best starter at times.
Kirby's 2025 season was not ideal, but it was delayed and hampered by a shoulder injury. He appeared at full strength throughout the second half (3.69 ERA, 3.11 xFIP from June 8 on), and he looked great in his 2026 debut.
Schlittler is still somewhat of a question mark. His 2025 ERA was incredible, but it was backed by a 4.11 xERA, 3.77 xFIP, and 3.84 SIERA. This does not indicate that he is bad — rather, he is more volatile than his ERA suggests.
Both bullpens are fully available after yesterday's matchup, which makes for a potentially close game.
However, with two loaded, ice-cold offenses and only one proven, elite starting pitcher on the mound, I'm leaning toward Seattle.
Tail all of Kev's picks by following him on the Action Network App:
Pick: Mariners ML (-115 or Better)
| | |
Guardians vs. Dodgers Moneyline Bets
By Sean Zerillo
I cashed a Dodgers moneyline ticket with some nice CLV (bet -235, closed -295) on Tuesday, and I'm looking to do the same on Wednesday following an injury to Guardians' star rookie Chase DeLauter.
DeLauter, who missed substantial time during his minor league career with injuries (138 games played across three seasons), fouled a pitch off his foot and could barely walk before leaving the game.
X-rays thankfully came back negative, but he'll need at least a day for the swelling to go down, and the Guardians will handle their injury-prone youngster with care.
My projection went from around -260 with DeLauter in Cleveland's lineup to north of -300 without him, and I would bet the Dodgers up to -285 straight, or -300 as a parlay piece.
Starting pitcher Yoshinobu Yamamoto (projected FIP range of 3.22 to 3.39; projected K-BB rate of 18.4% to 20.7%) has very few weaknesses after the early home run ball (career 0.73 HR/9; allowed 11 of 22 first time through the order).
Although they have yet to click fully, I still project the Dodgers as an all-star caliber offense (projected 126 wRC+) against any right-handed starter.
Read Zerillo's full Opening Pitch column for Wednesday, featuring all of his MLB picks and projections.
Pick: Dodgers ML (-285 or Better)
| | |
