The 2026 season is in full swing now, and Friday's MLB slate is packed with eight excellent games beginning with Yankees vs. Giants in the afternoon and ending after Midnight on the East Coast.
Our staff of MLB betting experts has been following every move this week, and they're locked in.
We've grabbed four of their Best MLB Picks Today and our Best Bets on Friday, March 27.
MLB Picks Today: Friday's Best Bets
The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Game | Time (ET) | Pick |
|---|---|---|
  | 4:35 PM | |
  | 9:40 PM | |
  | 9:45 PM | |
  | 10:10 PM | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
Yankees vs Giants Best Bet
By Jon Anderson
It's a very interesting "compare and contrast" with today's starting pitchers: Cam Schlittler and Robbie Ray. I think the public will hold too high an opinion of each guy, albeit for different reasons.
Ray threw 182.1 innings last year, and that followed a completely lost season after a Tommy John that cost him his 2024 season. It was an impressive volume feat for the Giants' lefty. But what you might not have noticed is that he lost a good bit of strikeout ability. His 24.6% K% last year came in four points below his career average.
The thing a lot of people remember about Schlittler is the dominant outing he had in the postseason last year against the Red Sox. The Yankees' righty threw eight scoreless with 12 strikeouts under the brightest lights of a postseason elimination game.
What we don't remember as much is the 10.2% BB% he posted in his Major League time, along with the dangerous game he plays, allowing fly balls as we've already talked about.
Speaking of short memories, all of the talk is negative on Aaron Judge right now. A lackluster WBC and then a huge 0/5 with four strikeouts in the season's first game. By the way, I don't believe the books are going to downgrade the guy in any way, but the public's money just might push toward this 'anti-Judge' side if this trend continues.
It's a great spot for him against Robbie Ray. Judge is one of the best to ever hold a baseball bat. I'd like to be on his side when the crowd starts to lean against him.
Money is also coming in to back the over in this early game.
The books are dragging their feet on the walk lines, so I can't say it for sure — but I'll be very curious to see if we can get a reasonable price on over 1.5 walks for either guy, particularly Schlittler against this patient Giants lineup.
Read Anderson's full Yankees-Giants preview here:
Pick: Over 7.5 (-122 or Better)
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Tigers vs Padres MLB System Pick
By Bet Labs
The Tigers are the trendy pick to win the AL Central, and they are talked about as a World Series contender.
At least in their debut, they certainly looked the part, thrashing the Padres 8-2 at their ballpark behind their ace, Tarik Skubal.
Tonight, Framber Valdez will make his Tigers' debut opposite Michael King.
Our Bet Labs "Road Dogs Interleague (SEASON)" system recommends backing Detroit to repeat at Petco Park at plus-money.
In Major League Baseball, road underdogs playing interleague (non-conference) games have historically been undervalued by oddsmakers.
Since 2016, despite winning only 43.3% of these games, these teams have generated a consistent positive ROI of 4.6%.
This trend has proven reliable across five consecutive seasons, indicating market inefficiencies in how these specific matchups are priced—likely due to lack of familiarity between leagues and public overconfidence in home and favorite teams.
In interleague play, road underdogs have shown themselves to be profitable on the money line recently.
They have only a 43.3% win percentage, but those teams have turned a 4.6% ROI for bettors since 2016 and have been profitable in five consecutive seasons.
Pick: Tigers ML (+101 or Better)
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Guardians vs Mariners Prediction, Pick
By Sean Zerillo
I lost a bet on the Under 6.5 runs on Thursday between these team, and only make the total for Friday's contest about a quarter of a run higher.
I don't project a significant difference between Mariners' starters Logan Gilbert (3.25 weighted FIP) and George Kirby (3.36), and Guardians righties Tanner Bibee (3.99) and Gavin Williams (4.00) grade out essentially the same as one another in my model, too.
First-pitch temperatures will be slightly warmer on Friday than on Thursday, but I don't see enough of a difference in the game to get from 6.5 to 7.5.
I liked Under 6.5 at plus money to -105 on Thursday. While it obviously didn't hit, I am much happier to bet Under at or above the key number of 7 to -115 for Friday, given the minimal adjustment in the projected total.
Pick: Under 7.5 (-120 or Better)
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Diamondbacks vs Dodgers Top Player Prop
By Nick Galaida
On Thursday, Kyle Tucker had 4 at-bats – his exit velocities in those at-bats were 102.6 mph, 96.1 mph, 94.3 mph, and 93.1 mph.
He looks healthy and has the best lineup protection that he’s had at any point during his MLB career, with Shohei Ohtani hitting in front of him and Mookie Betts slotted directly behind him.
Opposing pitcher Ryne Nelson had a good year in 2025 against lefties, but he doesn’t miss many bats.
The Diamondbacks also don’t have a single southpaw in their bullpen, which means Tucker should also get some quality opportunities in the late innings.
In his debut, he had 3 hits+runs+RBI against Arizona, keeping in trend with his 2025 final run.
Pick: Kyle Tucker 2+ Hits, Runs & RBIs (-140 or Better)
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