MLB Opening Day is scheduled for Thursday, March 30, and opening odds are starting to be released for the 15-game slate.
The slate of games begins at 1:05 p.m. ET, when Braves-Nationals and Giants-Yankees will both get going. There will be games spread out throughout the day, culminating with a trio of games that get started after 10 p.m. ET: Angels vs. Athletics, Diamondbacks vs. Dodgers and Guardians vs. Mariners.
Below you will find the opening odds for all 15 games via FanDuel and as of Tuesday evening. For up-to-the-minute MLB odds all season long, be sure to bookmark our MLB odds page.
| Matchup | Max Fried vs. Patrick Corbin |
| First Pitch | 1:05 p.m. ET |
| Braves Odds | -260 |
| Nationals Odds | +215 |
| Total | 7.5 |
| Matchup | Logan Webb vs. Gerrit Cole |
| First Pitch | 1:05 p.m. ET |
| Giants Odds | +144 |
| Yankees Odds | -172 |
| Total | 7 |
| Matchup | Kyle Gibson vs. Corey Kluber |
| First Pitch | 2:10 p.m. ET |
| Orioles Odds | +110 |
| Red Sox Odds | -130 |
| Total | 9 |
| Matchup | Corbin Burnes vs. Marcus Stroman |
| First Pitch | 2:20 p.m. ET |
| Brewers Odds | -148 |
| Cubs Odds | +126 |
| Total | 7.5 |
| Matchup | Eduardo Rodriguez vs. Shane McClanahan |
| First Pitch | 3:10 p.m. ET |
| Tigers Odds | +190 |
| Rays Odds | -230 |
| Total | 7 |
| Matchup | Aaron Nola vs. Jacob deGrom |
| First Pitch | 4:05 p.m. ET |
| Phillies Odds | +110 |
| Rangers Odds | -130 |
| Total | 6.5 |
| Matchup | Mitch Keller vs. Hunter Greene |
| First Pitch | 4:10 p.m. ET |
| Pirates Odds | +112 |
| Reds Odds | -132 |
| Total | 8.5 |
| Matchup | German Marquez vs. Blake Snell |
| First Pitch | 4:10 p.m. ET |
| Rockies Odds | +176 |
| Padres Odds | -210 |
| Total | 7.5 |
| Matchup | Max Scherzer vs. Sandy Alcantara |
| First Pitch | 4:10 p.m. ET |
| Mets Odds | -126 |
| Marlins Odds | +108 |
| Total | 6.5 |
| Matchup | Pablo Lopez vs. Zack Greinke |
| First Pitch | 4:10 p.m. ET |
| Twins Odds | -148 |
| Royals Odds | +126 |
| Total | 8.5 |
| Matchup | Alek Manoah vs. Miles Mikolas |
| First Pitch | 4:10 p.m. ET |
| Blue Jays Odds | -120 |
| Cardinals Odds | +102 |
| Total | 8 |
| Matchup | Dylan Cease vs. Framber Valdez |
| First Pitch | 7:08 p.m. ET |
| White Sox Odds | +136 |
| Astros Odds | -162 |
| Total | 7.5 |
| Matchup | Shohei Ohtani vs. Kyle Muller |
| First Pitch | 10:07 p.m. ET |
| Angels Odds | -245 |
| Athletics Odds | +200 |
| Total | 7 |
| Matchup | Zac Gallen vs. Julio Urias |
| First Pitch | 10:10 p.m. ET |
| Diamondbacks Odds | +154 |
| Dodgers Odds | -184 |
| Total | 7.5 |
| Matchup | Shane Bieber vs. Luis Castillo |
| First Pitch | 10:10 p.m. ET |
| Guardians Odds | -102 |
| Mariners Odds | -116 |
| Total | 6.5 |
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