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MLB Picks: Situational Predictions for Cubs vs Reds, Pirates vs Diamondbacks

MLB Picks: Situational Predictions for Cubs vs Reds, Pirates vs Diamondbacks article feature image
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Apr 24, 2026; Milwaukee, Wisconsin, USA; Pittsburgh Pirates starting pitcher Paul Skenes (30). Credit: Benny Sieu-Imagn Images

A 61% wind angle is live today!

Wednesday’s MLB slate is massive — every team in action — and the smartest edges stem from two spots where pitching and weather combine with strong, backtested outlooks.

PRO Systems (our proprietary, backtested trends) surface those edges for PRO subscribers; they get full system access and additional tools. Below are the clean, concise plays we like for the evening.

Transitioning from the big-picture setup into the picks, we're focusing on games where conditions and pitcher profiles historically affect the outcomes. Two systems lit up tonight, with picks for Cubs vs. Reds (7:40 p.m. ET) and Pirates vs. Diamondbacks (9:40 p.m. ET).

Here we go!

MLB Picks: Situational Best Bets for Cubs vs Reds, Pirates vs Diamondbacks

Reds vs. Cubs — Best bet: