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MLB Home Run Picks, Predictions: 5 HR Best Bets for Orioles-Royals, Padres-Rockies, More for April 22

MLB Home Run Picks, Predictions: 5 HR Best Bets for Orioles-Royals, Padres-Rockies, More for April 22 article feature image
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Pictured: Colson Montgomery. (Credit: Mark J. Rebilas-Imagn Images)

It's Wednesday, so you know I've got some bangers.

Read on for my Home Run Picks Today for Wednesday, April 22.


MLB Best Bets Today

The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.

GameTime (ET)Pick
Baltimore Orioles LogoKansas City Royals Logo
2:10 PM
Athletics LogoSeattle Mariners Logo
4:10 PM
Atlanta Braves LogoWashington Nationals Logo
6:45 PM
San Diego Padres LogoColorado Rockies Logo
8:40 PM
Chicago White Sox LogoArizona Diamondbacks Logo
9:40 PM
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.
Playbook

Orioles vs Royals Home Run Pick

Baltimore Orioles Logo
Wednesday, April 22
2:10 PM ET
MLB.TV
Kansas City Royals Logo
Carter Jensen 1+ Home Runs (+540)
FanDuel Logo

Carter Jensen has looked great this season, and the power looks for real.

This spot is a big plus going up against Chris Bassitt, who has been a gas can for lefty power over the past few seasons.

This ballpark is above average for power, and with winds blowing out, the weather should be a plus.

I have the true odds here around +450, making this a great bet.

Pick: Carter Jensen 1+ Home Runs (+540)



Athletics vs Mariners Home Run Pick

Oakland Athletics Logo
Wednesday, April 22
4:10 PM ET
MLB.TV
Seattle Mariners Logo
Shea Langeliers 1+ Home Runs (+460)
DraftKings  Logo

Logan Gilbert is a great pitcher, but he's struggled with righty power in his career (1.35 HR/9).

Shea Langeliers has been one of the best power hitters in the league since the All-Star Break last season and is priced far too high.

I have the true odds here around +375, making this a great bet.

Pick: Shea Langeliers 1+ Home Runs (+460)



Braves vs Nationals Home Run Pick

Atlanta Braves Logo
Wednesday, April 22
6:45 PM ET
MLB.TV
Washington Nationals Logo
Austin Riley 1+ Home Runs (+417)
DraftKings  Logo

Austin Riley isn't the same hitter that he used to be, but this spot is far too good.

Zack Littell has been an absolute gas can for righty power in his career and grades out as one of the best matchups in the league for righty power.

I have the true odds here around +350, making this a great bet.

Pick: Austin Riley 1+ Home Runs (+417)



Padres vs Rockies Home Run Pick

San Diego Padres Logo
Wednesday, April 22
8:40 PM ET
MLB.TV
Colorado Rockies Logo
Fernando Tatis Jr. o0.5 Home Runs (+375)
FanDuel Logo

Fernando Tatis Jr. isn't the same power hitter that he used to be, but this spot is far too good to ignore.

Tatis hasn't been hitting bombs this season, but the underlying stats are still good, with a 14% barrel rate.

The matchup vs. Tomoyuki Sugano is well above average, and this ballpark is one of the best in the league for power.

The weather should be a big plus for hitting, with temps in the high-70s and wind howling out to right field at 19 mph.

I have the true odds here around +300, making this a great bet.

Pick: Fernando Tatis Jr. o0.5 Home Runs (+375)



White Sox vs Diamondbacks Home Run Pick

Chicago White Sox Logo
Wednesday, April 22
9:40 PM ET
MLB.TV
Arizona Diamondbacks Logo
Colson Montgomery o0.5 Home Runs (+570)
FanDuel Logo

Colson Montgomery has been great to start the season (6 HRs) and comes into this game in great form.

The matchup is lefty/lefty, but Eduardo Rodriguez is a reverse-splits pitcher and has been an above-average matchup for lefty power in his career, and he grades out as a matchup that is well above average at this point in his career.

The roof will be open at Chase Field, and the weather should be a plus for hitting, with temps in the 80s and wind blowing out.

I have the true odds here around +450, making this a great bet.

Pick: Colson Montgomery o0.5 Home Runs (+570)



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About the Author
Grant NeifferVerified Action Expert

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