The Milwaukee Brewers host the Minnesota Twins on May 16, 2025. First pitch from American Family Field is scheduled for 8:10 p.m. ET; the game will be broadcast on MNNT and MLB.TV.
The Twins enter as -118 favorites on the moneyline with the over/under sitting at 7.5.
Find my Twins vs Brewers prediction and MLB betting preview below, as well as probable pitchers, betting trends, injury reports and more.
Twins vs Brewers Prediction
- Twins vs Brewers Pick: Brewers ML +102
My Brewers vs. Twins best bet is on Milwaukee to win outright. Make sure to find the best odds by checking our live MLB odds page.
Twins vs Brewers Odds
| Twins Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
-1.5 +150 | 7.5 -112o / -108u | -118 |
| Brewers Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
+1.5 -180 | 7.5 -112o / -108u | -102 |
Twins vs Brewers Projected Starting Pitchers
Twins vs Brewers MLB Betting Preview
For Friday’s matchup between the Minnesota Twins and Milwaukee Brewers, our top recommendation based on PRO Projections is to back the Brewers on the moneyline.
The Twins enter the game riding a hot streak, having won 10 consecutive games, with starting pitcher Joe Ryan set to face off against Chad Patrick.
Minnesota comes in as a favorite at -122, but there are several key factors that suggest the betting price may not be completely fair.
The Twins are currently grappling with significant injuries to vital players Byron Buxton and Carlos Correa. Buxton, in particular, is difficult to replace, leading the team with 10 home runs and serving as the catalyst atop the batting order.
The star outfielder has also contributed a robust +1.8 WAR.
While Correa doesn’t carry quite as much offensive weight, he still ranks above average in WAR and offers strong defensive value at shortstop.
Twins vs Brewers Pick, Betting Analysis
PRO Projections, which synthesize expert MLB insights and proprietary betting data, indicate that the Twins may be overpriced.
Taking into account the pitching matchup and roster health, our data suggests the fair value price should be closer to Brewers -101.
As such, backing the Brewers on the moneyline represents the best betting opportunity for Friday’s Rivalry Weekend matchup.
Pick: Brewers ML +102
Moneyline
Our best bet for this game is to take the Brewers on the moneyline. The Twins may be a bit overvalued in the market and have some health concerns across the roster.
Run Line (Spread)
While our best bet is on the Milwaukee moneyline, we're not betting the Brew Crew on the run line.
Over/Under
We didn't have a bet on the total for this Friday night showdown.
