The Houston Astros host the Colorado Rockies on April 16, 2026. First pitch from Daikin Park is scheduled for 8:10 p.m. EDT. The game will be broadcast on COLR.
The Astros are favored by -190 on the moneyline and by -1.5 on the run line. The Rockies are +160 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.
Find my MLB picks and Rockies vs Astros prediction below, as well as probable pitchers, weather report, and more.
Rockies vs Astros Prediction, Pick
- Rockies vs Astros Pick: Rockies Moneyline (+160)
My Rockies vs Astros best bet is on Colorado to win outright. Make sure to find the best odds by checking our live MLB odds page.
Rockies vs Astros Odds, Spread, Line
| Rockies Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -128 | 8.5 -122o / -100u | +160 |
| Astros Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +106 | 8.5 -122o / -100u | -190 |
- Rockies vs Astros spread: Astros -1.5 (+106), Rockies +1.5 (-128)
- Rockies vs Astros over/under: 8.5 (-122o / -100u)
- Rockies vs Astros moneyline: Rockies +160, Astros -190
Rockies vs Astros Kalshi Odds
Rockies vs Astros Pitchers
| RHP Juan Mejia (COL) | Stat | RHP Ryan Weiss (HOU) |
|---|---|---|
| 0-2 | W-L | 0-2 |
| 0.0 | fWAR (FanGraphs) | -0.1 |
| 5.40/6.49 | ERA /xERA | 7.36/5.46 |
| 4.96/5.23 | FIP / xFIP | 5.61/3.84 |
| 1.80 | WHIP | 2.09 |
| 2.7% | K-BB% | 16.1% |
| 25.0% | GB% | 28.6% |
| 101 | Stuff+ | 101 |
| 107 | Location+ | 95 |
Rockies vs Astros MLB Betting Preview
The Houston Astros enter the third game of this series looking to complete a dominant sweep after stifling the Colorado Rockies in back-to-back contests.
Following a narrow 7-6 victory in the opener, Houston leaned on a masterful performance from Spencer Arrighetti on Wednesday night.
Making his season debut after being recalled from Triple-A to cover for an injured Cody Bolton, Arrighetti carved through the Colorado lineup, racking up 10 strikeouts over six dominant innings to secure a 3-1 win.
The Astros' offense was sparked once again by Yordan Alvarez, who launched his seventh home run of the season—putting him in a tie for second across the majors.
While Houston has successfully snapped an eight-game skid with these two wins, the Rockies have spiraled in the opposite direction, dropping six straight after a promising four-game winning streak.
Health and lineup shifts are key storylines heading into this matchup. Colorado is monitoring first baseman Troy Johnston, who exited Wednesday’s game with a bruised right quadriceps after being hit by a pitch.
On a more positive note for Colorado, Hunter Goodman remains a legitimate threat against Houston, having already tallied three home runs and four RBIs against them this season.
Meanwhile, the Astros expect to welcome back veteran leader Jose Altuve, who was rested on Wednesday, adding even more firepower to a surging Houston squad.
How To Bet My Rockies vs Astros Pick, Betting Analysis
Despite the momentum sitting squarely in the Houston dugout, there is a compelling mathematical reason to look toward the Colorado Rockies as a live underdog in this finale.
This matchup fits the "Road Dogs Interleague" betting system from Evan Abrams, which identifies a specific market inefficiency in non-conference games. Historically, oddsmakers and the public tend to overvalue home favorites in interleague play due to a lack of familiarity between the two teams.
Data shows that since 2016, road underdogs playing interleague games have been remarkably profitable for bettors. While these teams win only 43.3% of the time, the high-payout odds they carry have resulted in a consistent 4.6% ROI.
This trend has held steady for five consecutive seasons, suggesting that the market consistently fails to price these "outsiders" correctly.
When you combine this historical edge with the fact that Colorado has hitters like Goodman who have found success in this specific park, the Rockies' moneyline offers significant value.
Pick: Rockies Moneyline (+160)
