Guardians vs Astros Prediction, Odds, Picks, MLB Betting Preview

Guardians vs Astros Prediction, Odds, Picks, MLB Betting Preview article feature image
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Photo by Troy Taormina-Imagn Images. Pictured: Cam Smith

The Houston Astros host the Cleveland Guardians on July 7, 2025. First pitch from Daikin Park is scheduled for 8:10 p.m. ET; the game will be broadcast on SCHN and MLB.TV.

The Astros enter as -142 favorites on the moneyline, while the Guardians are +120 to pull off the upset. The over/under, meanwhile, sits at 7.5.

Find my Guardians vs Astros prediction and MLB betting preview below, as well as probable pitchers, betting trends, injury reports, and more.

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Cleveland Guardians vs Houston Astros Prediction, Picks

  • Guardians vs. Astros Pick: Astros F5 -0.5 (-105, BetMGM)

My Astros vs. Guardians best bet is on the Astros first five innings on the run line. Make sure to find the best odds by checking our live MLB odds page.


Guardians vs Astros Odds, Line, Spread

Guardians Logo
Monday, July 7
8:10 p.m. ET
MLB.TV
Astros Logo
Guardians Odds
Run LineOver/UnderMoneyline
+1.5
-188
7.5
+100o / -120u
+120
Astros Odds
Run LineOver/UnderMoneyline
-1.5
+155
7.5
+100o / -120u
-142
Odds via bet365. Get up-to-the-minute MLB odds here.
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Guardians vs Astros Projected Pitchers

Tanner Bibee (CLE)StatColton Gordon (HOU)
4-9W-L3-1
0.8fWAR (FanGraphs)0.5
4.20/3.62ERA /xERA4.37/3.74
4.42/4.14FIP / xFIP4.39/3.66
1.24WHIP1.41
13.7K-BB%17.2
45GB%36.2
104Stuff+97
96Location+111

Guardians vs Astros MLB Betting Preview

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Cleveland Guardians Betting Preview: Need a Win

The Guardians come into this series ice cold and have lost 10 straight. They've struggled mightily at the plate, and that's due to continue tonight against Houston's Colton Gordon.

The Guardians have had more than their fair share of issues with lefties; they rank 28th in wRC+ and 30th in OPS against them. To make matters worse, Gordon is an emerging young arm who's due for positive regression.

Through nine big league starts, Gordon has displayed impeccable command, but he doesn't miss many bats. However, his hard-hit rate is in the 67th percentile, so he's due to see his BABIP come down, especially against a lineup that's last in hard-hit rate.


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Houston Astros Betting Preview: Upward Trend

The Astros have been trending upward, going 8-2 over their past 10 games, and have begun to take over the AL West.

Their lineup has spurred their most recent hot streak, as they hold the second-highest wRC+ over the last two weeks.

What's even more impressive about their production lately is that they're doing it without Jeremy Pena and Yordan Alvarez. We've seen the likes of Isaac Paredes and Cam Smith step up and support veterans Jose Altuve and Christian Walker.

Tonight, they get to face Cleveland's Tanner Bibee. Bibee has been solid for the Guardians this season and, like his counterpart, he enters this outing due for positive regression.

However, a drop-off in strikeouts this season has been the issue for Bibee, and the way the Astros have been swinging the bats, balls in play are bound to find some grass.


Guardians vs Astros Pick, Best Bets

This series is a matchup of two teams trending in the opposite direction. The Guardians have been horrid at the plate and have a sneaky tough matchup in front of them.

On the other side, the Astros have been cruising offensively and show no signs of slowing down.

With both bullpens taxed from the weekend, I'm taking them out of the equation by backing Houston on the run line in the first five.

Pick: Astros F5 -0.5 (-105)


Guardians vs Astros Betting Trends to Know


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About the Author
Doug is a college football, college basketball and MLB contributor at the Action Network. He produces content centered around actionable advice with the goal of helping readers become better bettors. He studied journalism at Rutgers and has previously covered the New York Mets, Indianapolis Colts, and Mid-Atlantic region for Perfect Game.

Follow Doug Ziefel @DougZiefel on Twitter/X.

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