The Detroit Tigers host the Cleveland Guardians on September 16, 2025. First pitch from Comerica Park is scheduled for 6:40 p.m. EDT; the game will be broadcast on CLEG.
Find my MLB betting preview and Guardians vs Tigers prediction below, as well as probable pitchers, betting trends, injury reports and more.
My Guardians vs Tigers Predictions, Parlay
- Tigers ML
- Jose Ramirez 1+ Hit
Parlay odds: +160
Guardians vs Tigers Odds
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -170 | 8 -115o / -105u | +120 |
| Tigers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +145 | 8 -115o / -105u | -140 |
Guardians vs Tigers Projected Starting Pitchers
| LHP Joey Cantillo (CLE) | Stat | RHP Casey Mize (DET) |
|---|---|---|
| 5-3 | W-L | 14-5 |
| 1.2 | fWAR (FanGraphs) | 1.9 |
| 3.36/3.63 | ERA /xERA | 3.83/3.78 |
| 3.57/3.71 | FIP / xFIP | 4.03/4.02 |
| 1.31 | WHIP | 1.27 |
| 15.8% | K-BB% | 15.5% |
| 41.2% | GB% | 40.2% |
| 89 | Stuff+ | 96 |
| 103 | Location+ | 106 |
Guardians vs Tigers Preview, Parlay Picks
Tigers ML
We will see a crucial series kick off in the Motor City tonight. Detroit can pull away and lock up the AL Central this week, as the Tigers hold a commanding 6.5-game lead over the Guardians.
Cleveland has closed the gap over the last few weeks, winning nine of their last ten games. Despite the hot streak, we’ll fade the Guardians tonight. Detroit has been outstanding at home this season (46-29) and holds the pitching advantage with Casey Mize on the mound.
Mize has enjoyed a strong year, carrying a 3.83 ERA and an 8-1 record at home.
Jose Ramirez 1+ Hit
The All-Star has delivered another strong season, leading the Guardians in batting average, home runs, and RBI.
Ramirez also draws a favorable matchup against Mize tonight. He’s 4-for-7 (.571) in his career against the Tigers’ starter, including two home runs.
Guardians vs Tigers Parlay
- Tigers ML
- Jose Ramirez 1+ Hit
Parlay odds: +160 (bet365)
Guardians vs Tigers Betting Trends
