Reds vs Marlins Prediction, Pick, Odds: Monday MLB Betting Preview, Parlay

The Miami Marlins host the Cincinnati Reds on April 21, 2025. First pitch from loanDepot park is scheduled for 6:40 p.m. EDT; the game will be broadcast on FDSOH.

Find my MLB betting preview and Reds vs Marlins prediction below, as well as probable pitchers, betting trends, injury reports and more.

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Cincinnati Reds vs Miami Marlins Parlay

• Cincinnati Reds ML
• Nick Lodolo Over 4.5 Strikeouts
• Miami Marlins Under 4.5 Runs

Parlay Odds: +210

Reds vs Marlins Odds, Spread, Line

Monday, Apr 21

6:40 p.m. ET

FDSOH

Reds Odds
Spread	Total	Moneyline
-1.5 +140	8 -110o / -110u	-115

Marlins Odds
Spread	Total	Moneyline
+1.5 -165	8 -110o / -110u	-105

Odds via bet365. Get up-to-the-minute MLB odds here.

Reds vs Marlins Prediction, Picks

Moneyline: Reds ML

The Cincinnati Reds take on the Miami Marlins tonight in Miami. The Reds are coming off a 24-2 win against the Baltimore Orioles and had everything working in their favor as they accumulated 25 hits.

The Reds should be able to bring that momentum to Miami tonight and will have their young stud, Nick Lodolo, on the mound.

Player Prop: Nick Lodolo Over 4.5 Strikeouts

Lodolo is a left-handed southpaw who has some dirty stuff. He is 2-1 on the season with a 2.31 ERA.

The Marlins are among the top-10 teams that strike out the most. I expect Lodolo to cruise past this number tonight.

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Team Total: Marlins Under 4.5 Runs

Miami will struggle on offense and I’d be surprised if the Marlins even manage three runs. I expect a low scoring game between these teams.

Take the under on the team total and let’s cash this 3-leg parlay.

Reds vs Marlins Same-Game Parlay, Picks

• Cincinnati Reds ML
• Nick Lodolo Over 4.5 Strikeouts
• Miami Marlins Under 4.5 Runs

Parlay odds: +210 (BetMGM)

Reds vs Marlins Betting Trends to Watch