The Cleveland Guardians (5-6) go for the sweep of the Chicago White Sox (2-9) at Progressive Field on Thursday, April 10. First pitch is scheduled for 1:10 p.m. ET; the game will be broadcast on Guardians TV and Chicago Sports Network.
Don't look now, but the White Sox have lost seven games in a row after a 2-2 start to the season. Jonathan Cannon tries to play stopper for Chicago on Thursday; Cleveland gives the ball to Gavin Williams.
Continue below for my White Sox vs Guardians prediction and pick for the Thursday series finale.
My White Sox vs Guardians Prediction
- White Sox vs Guardians pick:Over 7.5 (-105 | Play to -110)
My White Sox vs Guardians best bet is Over 7.5. Make sure to find the best odds by checking our live MLB odds page.
White Sox vs Guardians Odds
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -120 | 7.5 -105 / -115 | +185 |
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +100 | 7.5 -105 / -115 | -225 |
White Sox vs Guardians Projected Starting Pitchers
Tony Sartori's White Sox vs Guardians Preview
Chicago White Sox Betting Preview
Right-hander Jonathan Cannon is slated to take the mound for the Chicago White Sox and should serve as a strong fade candidate. Cannon made his Major League Baseball debut last season in what was a difficult campaign for the right-hander.
Through 23 games, he posted a 5-10 record with a 4.49 ERA and a 1.33 WHIP.
Well, those struggles have continued into this season as Cannon ranks in the bottom half of the league in expected ERA (xERA), average exit velocity, barrel rate and hard-hit rate. This lack of success will likely continue against the Cleveland Guardians, a team he faced once last year.
In that outing, Cannon surrendered three runs on seven hits in fewer than six innings.
Following Cannon is a fade-worthy bullpen. Chicago’s relief staff ranks in the bottom 10 in ERA, fielding independent pitching (FIP), expected FIP (xFIP) and wins above replacement (WAR).
Cleveland Guardians Betting Preview
Cleveland’s bullpen has also struggled in 2025. The Guardians’ relief staff ranks among the league's bottom half in FIP, xFIP and WAR.
The White Sox will also have to deal with Cleveland right-hander Gavin Williams, who posted a 3-10 record through 16 starts with a 4.50 ERA and a 1.37 WHIP in 2024.
That slide has continued into 2025. Through two starts, the former first-round draft pick has a 4.50 ERA and a 1.63 WHIP.
Like Cannon, Williams’ analytics suggest brighter days may not be ahead. He ranks in the bottom half of the league in xERA, expected batting average (xBA) and average exit velocity.
White Sox vs Guardians Prediction, Betting Analysis
Also like Cannon, Williams has struggled against Thursday’s opponent. In his lone start against Chicago, he surrendered five runs on seven hits over four innings.
There were 10 total runs scored in that contest, and a similar result is likely. Through 12 combined plate appearances against Williams, the current White Sox roster boasts a .364 batting average, a .545 slugging percentage and a .413 weighted on-base average (wOBA).
Meanwhile, the current Guardians roster owns a .368 batting average, a .632 slugging percentage and a .439 wOBA through 20 combined plate appearances against Cannon.
Pick: Over 7.5 (-105 | Play to -110)
Moneyline
I lean toward Cleveland, but don't want to lay the juice with Williams.
Run Line (Spread)
I like the Guardians to cover, but don't want to bet on them for the same reason listed above.
Over/Under
As mentioned, I'm betting Over 7.5 at -105.
My Pick: Over 7.5 (-105)
