The Chicago White Sox host the Baltimore Orioles on September 17, 2025. First pitch from Rate Field is scheduled for 2:10 p.m. EDT; the game will be broadcast on CHSN.
The Orioles took the first two games and will try to sweep the White Sox today.
Find my MLB betting preview and Orioles vs White Sox prediction below, as well as probable pitchers, betting trends, injury reports and more.
My Orioles vs White Sox Prediction
- Orioles vs White Sox pick: Under 8
My Orioles vs White Sox best bet is Under 8 total runs in this game. Make sure to find the best odds by checking our live MLB odds page.
Orioles vs White Sox Odds, Spread, Best Bet
| Baltimore Orioles Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +145 | 8 -120o / 100u | -120 |
| Chicago White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -175 | 8 -120o / 100u | +100 |
Orioles vs White Sox Run Line: Orioles -1.5 (+145); White Sox +1.5 (-175)
Orioles vs White Sox Totals: 8 (O -120 / U +100)
Orioles vs White Sox Moneyline: Orioles -120; White Sox +100
Orioles vs White Sox Best Bet: Under 8
Orioles vs White Sox Projected Starting Pitchers
| RHP Tyler Wells (BAL) | Stat | LHP Martin Perez (CHW) |
|---|---|---|
| 1-0 | W-L | 1-5 |
| 0.2 | fWAR (FanGraphs) | 0.9 |
| 2.31 / 2.31 | ERA / xERA | 3.27 / 5.22 |
| 3.92 / 3.93 | FIP / xFIP | 4.05 / 4.83 |
| 0.60 | WHIP | 1.05 |
| 21.4 | K-BB% | 10.5 |
| 41.9 | GB% | 37.9 |
| 99 | Stuff+ | 81 |
| 106 | Location+ | 101 |
Orioles vs White Sox Preview
The first game of this series went under the total, and the difference with yesterday's bloated score was the quality of the starters.
The Orioles' Tyler Wells has been great in his two outings this month after returning from a torn UCL surgery. The right-hander allowed two runs in five innings against the Padres on September 2, and gave up just one run and one hit (a solo homer, of course) against the Pirates in six and 2/3 innings on September 10.
He will face one of the worst offenses in MLB this season as the White Sox rank 27th in wRC+ with an 88 rating.
Chicago will send Martin Perez to the mound. The lefty has a 3.27 ERA in 2025, although more interesting for today are his splits. He holds a 1.67 ERA at home and a 2.05 ERA in day games this season.
Plus, the Orioles do worse against southpaws such as Perez, going from 18th overall in wRC+ to the 20th spot versus lefties.
This aligns with our Bet Labs recommendation to go with the under.
This system capitalizes on an overlooked weather edge in MLB totals betting. It focuses on regular-season games where elevated humidity — ranging from 45 to 95 — intersects with moderate temperatures and neutral wind patterns.
Despite assumptions that humidity boosts offense, public bettors are fading these conditions, which actually correlate with suppressed scoring in certain environments.
In these spots, the home team has stayed under in recent games, with their five-game over rate sitting below 40, suggesting low offensive rhythm.
The market has also subtly corrected, with the total dropping from open to close, and the overall percentage of bets on the over remains modest, between 6 and 29.
These indicators combine to identify under-the-radar under spots where public narratives misalign with actual scoring trends.
Pick: Under 8
Orioles vs White Sox Betting Trends
For the latest on MLB injuries, be sure to check out our MLB Injury Report page.
