The Boston Red Sox host the Houston Astros on May 1, 2026. First pitch from Fenway Park is scheduled for 7:10 p.m. EDT. The game will be broadcast on SCHN.
The Astros are favored by -125 on the moneyline and by -1.5 on the run line. The Red Sox are +105 on the moneyline and +1.5 on the run line. The total is set at 9.5 runs.
Find my MLB picks and Astros vs Red Sox prediction below, as well as probable pitchers, weather report, and more.
Astros vs Red Sox Prediction
- Astros vs Red Sox Pick: Shay Whitcomb Under 0.5 Hits
My Astros vs Red Sox best bet is on Shay Whitcomb to record under 0.5 hits. Make sure to find the best odds by checking our live MLB odds page.
Astros vs Red Sox Odds, Spread
| Astros Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -193 | 9.5 -100o / -120u | +105 |
| Red Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 +165 | 9.5 -100o / -120u | -125 |
- Astros vs Red Sox moneyline: Astros +105, Red Sox -125
- Astros vs Red Sox over/under: 9.5 (-100o / -120u)
- Astros vs Red Sox spread: Astros -1.5 (+165), Red Sox +1.5 (-193)
Astros vs Red Sox Probable Pitchers
| Mike Burrows | Stat | TBD |
|---|---|---|
| 12-20 | W-L | 12-19 |
| 0.1 | fWAR (FanGraphs) | |
| 6.25 / 3.83 | ERA / xERA | |
| 5.15 / 4.13 | FIP / xFIP | |
| 14.7 | K-BB% | |
| 39.6 | GB% | |
| .378 | BABIP | |
| 94 | Stuff+ | |
| 96 | Location+ |
Astros vs Red Sox MLB Betting Preview
Editor’s note: This article was transcribed from the latest episode of the Payoff Pitch Podcast.
By Derek Carty
For a lot of the same reasons I give out these types of plays, Shay Whitcomb has a high pinch-hit risk. THE BAT X projects it at about 51% today once the bullpen comes in.
He's likely facing a pitcher in Jake Bennett who hasn't been given a very long leash in the minors — more of a 75- to 80-pitch kind of guy. So if that's what we get from him today, there's a decent chance we only get two at-bats out of Whitcomb — more likely three, but there is a chance of only two, which would be pretty awesome.
When we have that high of a pinch-hit risk, especially against a short-leash pitcher, it's going to show value.
Astros vs Red Sox Pick, Betting Analysis
I'm looking at Shay Whitcomb under 0.5 hits. +107 at Caesars is the best line on the board.
Pick: Shay Whitcomb Under 0.5 Hits
