Astros vs. Angels Odds & Betting Predictions - September 28, 2025

Astros at Angels

7:07 pm • SCHN

Houston Astros

15-23

6 - 2

Los Angeles Angels

15-23

pitcher		team	era	w-l
S.Aldegheri			7.90	0-2
L.McCullers			6.51	2-5

MatchupOpenSpreadTotalMoneyline
Astros 15-23	-1.5	-1.5+134	o9-104	-117
Angels 15-23	u9.5	+1.5-164	u9-112	-102

Sunday 7:07 p.m.

September 28, 2025

Angel StadiumAnaheim

L.McCullers o3.5 Ks+128

1.28u

McCullers will make his return in what will be a meaningless game for Houston. He might not go more than 4-5 innings, but that’s plenty in this matchup. The Angels are the highest-strikeout team in the league vs. RHP and they’ve ramped it up in September. LA has an absurd 32.2% K% vs. RHP this month.

No props found

MLB Public Betting

Angels are 3-2 in their last 5 games.
Angels are 3-2 in their last 5 games against the spread
Angels are 9-11 in their road games against the spread
The totals have gone OVER in 1 of Angels' last 5 games
The totals have gone OVER in 6 of Angels' 18 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Angels	19-19	10-8	9-11	5-4	14-15
Astros	15-23	8-11	7-12	4-11	11-11

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Angels	18-20	6-12	12-8	2-7	16-13
Astros	24-12-2	14-5	10-7-2	9-6	14-6-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Angels	15-23	8-10	7-13	4-5	11-18
Astros	15-23	9-10	6-13	5-10	10-12

date	opponent	score	spread	over/under	moneyline
Sep 28th	HOU	L 1-6	+1.5 L	U 9	HOU +121
Sep 27th	HOU	W 4-3	+1.5 W	U 9	LAA +110
Sep 26th	KC	L 4-9	+1.5 L	O 9.5	KC +112
Sep 25th	KC	W 3-2	+1.5 W	U 8.5	LAA -106
Sep 24th	KC	L 4-8	+1.5 L	O 9	KC +140

Anthony Rendon
3B
Rendon is out with hip
Out
Grayson Rodriguez
SP
Rodriguez is out with elbow
Out
Alek Manoah
SP
Manoah is out with finger
Out
Ryan Johnson
SP
Ryan Johnson (illness) scratched Sunday. George Klassen will start for the Angels.
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RL.McCullers, P	54	3	4	1
LC.Gordon, P	68	5	3	0
RJ.Murray, P	24	1	2	1

HITTERS	H-AB	R	HR	RBI
1Z.Cole, LF	0-4	0	0	0
2M.Dubon, SS	1-5	1	0	0
3V.Caratini, 1B	1-4	1	1	1
4Y.Diaz, C	2-5	1	1	2
5J.Sanchez, DH	2-5	0	0	0
6C.Smith, RF	1-4	1	0	0
7R.Urias, 3B	1-3	1	1	2
8B.Matthews, 2B	2-4	1	1	1
9J.Melton, CF	1-3	0	0	0

PITCHER	PC	IP	K	ER
LS.Aldegheri, P	96	4.2	5	4
RC.Brogdon, P	27	1.1	2	2
RR.Zeferjahn, P	21	1	1	0
RS.Bachman, P	12	1	0	0
LS.Peralta, P	13	1	1	0

HITTERS	H-AB	R	HR	RBI
1L.Rengifo, 3B	0-4	0	0	0
2M.Trout, DH	1-1	1	1	1
2L.O'Hoppe, PH	0-3	0	0	0
2L.O'Hoppe, DH	0-3	0	0	0
3J.Adell, RF	1-4	1	0	0
4C.Taylor, LF	1-3	0	0	0
5C.Moore, 2B	0-4	0	0	0
6C.Kieboom, 1B	1-4	0	0	1
7S.Rivero, C	1-4	0	0	0
8D.Guzman, SS	1-4	0	0	0
9B.Teodosio, CF	0-2	0	0	0
9T.Ward, PH	0-1	0	0	0