Astros vs. Angels Odds & Betting Predictions - September 28, 2025

Astros at Angels

1:38 am • SCHN
6 - 1
Starting Pitchers
pitcherteameraw-l
Caden Dana logoC.DanaLos Angeles Angels logo6.400-4
AJ Blubaugh logoA.BlubaughHouston Astros logo1.693-1

Astros at Angels Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Astros
15-23
-1.5
-1.5+113
o9-109
-146
Angels
15-23
u9
+1.5-135
u9-110
+121
location pinSunday 1:38 a.m.
September 28, 2025
Angel StadiumAnaheim
Astros vs. Angels Expert Picks
Wags Wins
Wags Wins
Last 30d: 249-270-6 (-9.8u)
LAA +125
1u

Prop Odds Comparison

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No props found

Line Movement Tracker

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Astros vs. Angels Public Betting Percentages

Away Logo

Astros

Public

78%

Bets%

22%

Money%

MLB Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Angels
19-1910-89-115-414-15
Astros
15-238-117-124-1111-11

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Angels
18-206-1212-82-716-13
Astros
24-12-214-510-7-29-614-6-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Angels
15-238-107-134-511-18
Astros
15-239-106-135-1010-12

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 27thHOUW 4-3+1.5 WU 9LAA +110
Sep 26thKCL 4-9+1.5 LO 9.5KC +112
Sep 25thKCW 3-2+1.5 WU 8.5LAA -106
Sep 24thKCL 4-8+1.5 LO 9KC +140
Sep 21st@COLL 1-3-1.5 LU 11.5COL -107

Angels vs. Astros Injury Updates

Angels Injuries

  • Anthony Rendon
    3B

    Rendon is out with hip

    Out

  • Grayson Rodriguez
    SP

    Rodriguez is out with elbow

    Out

  • Alek Manoah
    SP

    Manoah is out with finger

    Out

  • Ryan Johnson
    SP

    Ryan Johnson (illness) scratched Sunday. George Klassen will start for the Angels.

    Out

Astros Injuries

    Astros vs. Angels Box Score
    Astros Player Stats
    Projected
    PITCHERPCIPKER
    AJ Blubaugh logoRA.Blubaugh, P70420
    Enyel De Los Santos logoRE.De Los Santos, P14120
    J.P. France logoRJ.France, P58351
    Craig Kimbrel logoRC.Kimbrel, P16120
    HITTERSH-ABRHRRBI
    Jose Altuve logo1J.Altuve, 2B1-1000
    Brice Matthews logo1B.Matthews, PH0-3000
    Brice Matthews logo1B.Matthews, 2B0-3000
    Isaac Paredes logo2I.Paredes, DH0-1000
    Victor Caratini logo2V.Caratini, PH0-3000
    Victor Caratini logo2V.Caratini, DH0-3000
    Carlos Correa logo3C.Correa, 3B0-1000
    Ramon Urias logo3R.Urias, 3B0-3000
    Christian Walker logo4C.Walker, 1B2-4222
    Yainer Diaz logo5Y.Diaz, C1-4100
    Zach Cole logo6Z.Cole, CF2-3212
    Jesus Sanchez logo7J.Sanchez, RF1-4112
    Mauricio Dubon logo8M.Dubon, SS0-3000
    Taylor Trammell logo9T.Trammell, LF0-3000
    Angels Player Stats
    Projected
    PITCHERPCIPKER
    Caden Dana logoRC.Dana, P93755
    Jose Urena logoRJ.Urena, P31211
    HITTERSH-ABRHRRBI
    Luis Rengifo logo1L.Rengifo, 3B0-4000
    Luis Rengifo logo1L.Rengifo, LF0-4000
    Mike Trout logo2M.Trout, DH1-3100
    Taylor Ward logo3T.Ward, LF1-2000
    Carter Kieboom logo3C.Kieboom, PH0-1000
    Carter Kieboom logo3C.Kieboom, 1B0-1000
    Jo Adell logo4J.Adell, RF1-4001
    Logan O'Hoppe logo5L.O'Hoppe, C0-3000
    Christian Moore logo6C.Moore, 2B0-3000
    Oswald Peraza logo7O.Peraza, 1B0-3000
    Oswald Peraza logo7O.Peraza, 3B0-3000
    Denzer Guzman logo8D.Guzman, SS0-3000
    Bryce Teodosio logo9B.Teodosio, CF0-3000

    Astros vs. Angels Odds Comparison

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    Astros at Angels Team Totals

    MatchupOverUnder
    Astros
    15-23
    N/A
    N/A
    Angels
    15-23
    N/A
    N/A