The Los Angeles Chargers (1-0) and Las Vegas Raiders (1-0) play the second game of the Monday Night Football doubleheader on Sept. 15 to close NFL Week 2. Chargers vs Raiders kickoff is set for 10:00 p.m. ET from Allegiant Stadium in Las Vegas, Nev. The game will broadcast live on ESPN.
Chargers vs Raiders odds have the Chargers as -194 moneyline favorites and the Raiders +162 underdogs. The game total is 46.5 points. The Chargers are 3.5-point favorites on the spread.
Find Chargers vs Raiders predictions and picks in my Monday Night Football preview below.
Los Angeles Chargers vs Las Vegas Raiders Prediction
- Chargers vs Raiders pick: Raiders +3.5
My Chargers vs Raiders best bet is the Raiders to cover the spread. Make sure to find the best odds by checking our live NFL odds page.
Chargers vs Raiders Odds, Spread, Moneyline, Over/Under, Best Bet
| Chargers Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
-3.5 -110 | 46.5 -110o / -110u | -194 |
| Raiders Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
+3.5 -110 | 46.5 -110o / -110u | +162 |
- Chargers-Raiders Moneyline: Chargers -194, Raiders +162
- Chargers-Raiders Total: 46.5
- Chargers-Raiders Spread: Chargers -3.5, Raiders +3.5
- Chargers-Raiders Best Bet: Raiders +3.5 (-110)
Chargers vs Raiders Monday Night Preview
Geno Smith has changed the landscape of the Raiders’ organization, so it’s worth digging into his level of play in his Las Vegas debut.
On the surface, Smith impressed with his numbers, going 24-of-34 for 362 passing yards, but it was the way he attacked all areas of the field that really stood out. Smith completed 10 passes near the hash marks in the middle of the field, nine toward the right sideline and five near the left sideline.
Smith also pushed the ball down the field with success, completing 4-of-5 attempts that traveled 20 yards past the line of scrimmage. According to Sharp Football, 14.5% of Vegas’ offensive plays gained 20+ yards against the Patriots a week ago, which was the second-highest rate in the league, and nearly triple the rate the Raiders offense posted in 2024.
It gives me confidence that Pete Carroll and the coaching staff realize where their bread is going to be buttered this year. The Raiders had the second-highest neutral game-script passing rate in Week 1 — and for good reason. More than 70% of Smith’s attempts went for either a first down or a touchdown, which was the highest rate of any quarterback to open the season.
The Chargers offense will not be easy to defend as a healthy Justin Herbert looks locked in to begin 2025 — but the Bolts may be more one-dimensional than the usual Jim Harbaugh squad.
Lead running back Omarion Hampton failed to gain positive yards on 33% of his carries in Week 1, netting just 0.6 yards per rush before contact. The Raiders defense allowed the Patriots' backs to gain just 3.5 yards per carry on the ground a week ago. I do not expect either running game to find difference-making success.
Looking at the entirety of Action Labs’ data, home underdogs of 3-6 points in Week 2 have covered at a 59% rate dating back to 2003. This trend is not just specific to Week 2, either.
Looking at all of September's games, home underdogs inside of the division of 3.5 or more points are 44-30 (59.5%) with a 13.9% ROI. Over the previous five seasons, in addition to including one game last week that fits into this category (Browns +5.5), the cover rate for these teams has only increased, going 12-5-1 (70.6% ATS).
The environment in Vegas may not be conducive to a strong home-field advantage for the Raiders, but it has mattered in this specific rivalry.
The Chargers are just 2-3 straight up when playing Las Vegas on the road, and one of those wins came in overtime by three points.
Chargers-Raiders Best Bet
The simple analysis is that there is a level of uncertainty with how teams are taking shape to begin a new season that makes taking the points a profitable endeavor long-term.
The Chargers are riding high after that win over the Chiefs in Brazil — 60% of bettors are with them to win with margin against the Raiders on Monday night, which makes it a perfect opportunity to back the home underdog.
Pick: Raiders +3.5
Spread
As mentioned, I like Raiders' spread line for this matchup.
Moneyline
I will not be betting on either side of the moneyline.
Over/Under
I'm also staying away from game total.
Chargers vs Raiders Betting Trends
- 51% of bets and 52% of the money are on the Chargers to cover the spread
- 92% of bets and 54% of the money are on the UNDER
- 90% of bets and 90% of the money are on the Chargers moneyline
Chargers vs Raiders Viewing Info: Channel, Start Time, Streaming
| Location: | Allegiant Stadium in Las Vegas, Nev. |
| Date: | Monday, Sept. 15 |
| Time: | 10 p.m. ET |
| TV / Streaming Options: | ESPN |
Chargers vs Raiders Latest Injuries
Chargers Injuries
| Player | Status |
|---|---|
| LB Denzel Perryman | Out (ankle) |
| DB Elijah Molden | Out (hamstring) |
| LB Daiyan Henley | Questionable (illness) |
| LB Del'Shawn Phillips | Questionable (toe) |
Raiders Injuries
| Player | Status |
|---|---|
| C Jackson Powers-Johnson | Out (concussion) |
| TE Brock Bowers | Questionable (knee) |
