The Kansas City Chiefs (3-0) and Los Angeles Chargers (2-1) face off as part of NFL Week 4's Sunday late afternoon slate, with kickoff set for 4:05 p.m. ET from SoFi Stadium in Inglewood, Calif. The game will be broadcast live on CBS and can be streamed on platforms like Paramount+ or YouTube TV.
The Chiefs are consensus 7-point favorites over the Chargers on the spread (Chiefs -7), and the over/under is currently set at 41 points. The spread opened at Chiefs -4 but moved up to -9 on Sunday night after Justin Herbert left the Chargers' loss to the Steelers with an ankle injury.
However, in the latest Chiefs vs. Chargers injury news, Justin Herbert is officially active today. With Herbert good to go, the Chiefs are now -310 favorites on the moneyline to win outright, while the Chargers are +277 to pull off the upset.
For the Chiefs, injuries to Isiah Pacheco and Hollywood Brown combined with Travis Kelce's inefficiency haven't stopped Patrick Mahomes from winning games, albeit by scores of 27-20, 26-25 and 22-17.
Let's get into my Chiefs vs. Chargers prediction and my NFL predictions for Week 4.
Chiefs vs. Chargers Picks
Spread
I'm backing the Chargers, but not over the full game. We'll put our bet on Los Angeles to cover the first-half spread.
Moneyline
I'm not betting the moneyline in this game.
Over/Under
I have no pick for this game's over/under.
Prediction
Pick: Chargers to cover the 1H spread (+4.5)
Chiefs vs. Chargers Odds, Lines
| Chiefs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-7 -120 | 41 -110o / -110u | -310 |
| Chargers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+7 +100 | 41 -110o / -110u | +275 |
- Chiefs vs. Chargers Spread: Chiefs -7
- Chiefs vs. Chargers Total: Over/Under 41 points
- Chiefs vs. Chargers Moneyline: Chiefs -310, Chargers +277
- Chiefs vs. Chargers Pick: Chargers 1H +4.5 (-120)
- 57% of bets and 49% of the money are on the Chiefs to cover the spread.
- 91% of bets and 88% of the money are on the over.
- 93% of bets and 83% of the money on the moneyline are on the Chiefs.
Our Chargers vs. Chiefs best bet is on Los Angeles to cover the first-half spread. For all of your NFL bets, be sure to find the best lines by using our live NFL odds page.
NFL Week 4 Preview
By Matt Trebby
The Chiefs are 3-0, but all three wins were by one score and they haven't been too convincing so far this season. The defense held strong last week in Atlanta, holding Kirk Cousins to just 17 points and coming up big late in the game.
This week, Kansas City faces a familiar quarterback in a new system. The Chiefs are used to facing Justin Herbert, but this won't be the same kind of offense they're used to preparing for.
For the Chargers, Herbert appears likely to play through an ankle sprain. Expect Los Angeles' attack to remain run-heavy, especially here as it tries to keep Patrick Mahomes off the field.
Is this a perfect spot to fade the Chiefs?
Sunday’s Week 4 game may be tough to get up for after the red carpet’s been rolled out in each of the first three weeks. Kansas City’s three games have all been get-up spots, from the season opener, to the home game vs. Joe Burrow, then Sunday Night Football. Now, the Chiefs are laying a bunch of chalk on the road to a team they’re expected to beat.
The best way to fade the Chiefs and bet the Chargers, in my opinion, is the first half. The Bolts probably don’t have enough ammo over four quarters to out-duel Mahomes without key players, but I’d back Jim Harbaugh and L.A. to cover the first two.
Mahomes is just 3-10 against the spread in the first half over his last 13 starts, with only Bryce Young posting a worse record over that span.
What also helps this handicap is PRO insights favoring a low-scoring game, which in turn helps a big underdog catching points. Our projections make the total of 40 closer to 38.1, and sharp money’s flooding the under, too.
It’s a sleepy spot for Kansas City — at least perhaps to start.
Roll with the Chargers to cover the first half spread.
Pick: Chargers 1H +4.5 (-120)
How to Watch: Time, Channel, Streaming
| Location: | SoFi Stadium |
| Date: | Sunday, Sept. 29 |
| Kickoff Time: | 4:25 p.m. ET |
| TV / Streaming: | CBS / Paramount+ |
Chiefs vs. Chargers is scheduled to kick off at 4:25 p.m. ET from SoFi Stadium in Inglewood, Calif., on Sunday, Sept. 29. The game is broadcasted live by CBS and is streaming on Paramount+ and YouTube TV.
NFL Weather
