The Indianapolis Colts (8-2) and Kansas City Chiefs (5-5) face off today in Week 12 of the NFL season. Kickoff is set for 1 p.m. ET from GEHA Field at Arrowhead Stadium in Kansas City, Mo. Colts vs Chiefs will broadcast on CBS.
The Chiefs are 3.5-point favorites over the Colts on the spread (Chiefs -3.5), with the over/under set at 50.5 (-105o / -115u). Kansas City is a -198 moneyline favorite while Indianapolis is a +164 underdog.
Let's get into my Colts vs Chiefs predictions for today's AFC clash — plus the latest NFL lines, betting trends, viewing information, weather forecast and more.
Colts vs Chiefs Predictions, Picks
- Colts vs Chiefs pick: Under 49.5 (-110)
My Chiefs vs Colts best bet is on the under at 49.5 total points. Find the best odds by checking our live NFL odds page.
Colts vs Chiefs Odds
| Colts Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+3.5 -110 | 50.5 -105o / -115u | +164 |
| Chiefs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-3.5 -110 | 50.5 -105o / -115u | -198 |
Colts vs Chiefs Preview Prediction
The Colts come into this marquee matchup off a bye week, and that extra time to prepare will impact this matchup in multiple ways.
Offensively, it's given them time to scheme against a Kansas City defense that has been stout at home.
For Indianapolis, if the Colts are going to keep this game tight, they will have to run the ball heavily and control the clock.
Fortunately, they'll have an excellent opportunity to do so as the Chiefs are 17th in yards per rush allowed and 23rd in EPA per rush allowed.
A run-heavy scheme will allow them to put together methodical drives, take the load off Daniel Jones, and most importantly, keep the Chiefs offense off the field.
Keeping Patrick Mahomes and company on the sidelines is critical, as that unit is motivated to get right in this matchup.
Above, I alluded to how the Chiefs are motivated to get right in this matchup.
We should see Patrick Mahomes and the offense force the issue for the Chiefs, who have lost their last two games.
Since becoming the starting quarterback, Mahomes has never lost three games in a row in his career.
If Kansas City is going to snap its skid, it's going to be on the arm of Mahomes.
The Chiefs rank fourth in passes per game, and the absence of Isaiah Pacheco will only force them to be more pass-heavy in this matchup.
However, they are going against a Colts defense that ranks 12th in opponent completion percentage, yards per pass allowed, and sack rate.
That has all helped them attain their spot at eighth in EPA per pass allowed, and it has come mainly without two of their top defensive players, Charvarius Ward and the newly acquired Sauce Gardner.
With Xavier Worthy questionable for this matchup, the Colts have the potential to take away Rashee Rice and force someone else to beat them.
So, while the motivation is high for Kansas City, the weight of the matchup may be higher.
Colts vs Chiefs Prediction, Over/Under Best Bet
This matchup has one of the highest totals on the slate, but the star power on these offenses has overshadowed the key factors of this total.
We should see the Colts make a concerted effort to possess the ball, as they can control the trenches and grind away behind Jonathan Taylor.
That will force a motivated Mahomes to air it out against a Colts defense that is excellent and is only getting stronger.
Expect this game to be a potential playoff preview as these teams battle in a tight, but low-scoring affair.
Take the under.
Colts vs Chiefs Best Bet
- Under 49.5 (-110)
Colts vs Chiefs Betting Trends
Colts vs Chiefs Viewing Info: Channel, Start Time, Streaming
| Location: | GEHA Field at Arrowhead Stadium in Kansas City, Mo. |
| Date: | Sunday, Nov. 23 |
| Time: | 1 p.m. ET |
| TV / Streaming Options: | CBS |
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Colts vs Chiefs Weather Forecast
