The Indianapolis Colts (6-7) and Denver Broncos (8-5) will face off in NFL Week 15 at 4:25 p.m. ET from Empower Field at Mile High in Denver. The game will be broadcast live on CBS and can be streamed on Paramount+.
Let's get into my Broncos vs Colts predictions and NFL picks.
The Broncos are favored by 4.5 points with the game total set at 43.5 points scored. The Broncos are -198 favorites to win outright, while the Colts are +164 to pull off the upset.
The Colts won 25-24 last week over the Patriots. Anthony Richardson only threw for 109 yards, but the Colts ran for 144 as a team and eked out a win. The Broncos are coming off their bye week and have won 3 straight games. Denver is averaging 36 points per game during its winning streak.
Colts vs. Broncos Prediction
Spread
I'll pass on betting either side here.
Over/Under
I've had my eyes on this spot for a few weeks. I'm on the under for this game between two teams coming off their bye.
My Pick: Under 44 (-110)
Colts vs. Broncos Odds, Spread, Over/Under
| Colts Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+4.5 -110 | 43.5 -112o / -108u | +164 |
| Broncos Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-4.5 -110 | 43.5 -112o / -108u | -198 |
- Colts vs. Broncos spread: Broncos -4.5
- Colts vs. Broncos over/under: 43.5 points scored
- Colts vs. Broncos moneyline: Broncos -198, Colts +164
- Colts vs. Broncos best bet: Under 44 (BetMGM)
MyColts vs. Broncos best bet is on the under, with the best odds currently available at BetMGM. For all of your NFL bets, be sure to find the best lines by using our live NFL odds page.
Indianapolis Colts vs. Denver Broncos Preview
This was one of my hot reads on Sunday night — one of the two bets I made for Week 15 right away.
These teams are both coming off their bye week, so there’s no edge there for either side. We do have a matchup between defenses that should be poised to perform well here.
The Broncos defense will be disappointed with how efficient Jameis Winston was two weeks ago. Winston threw three interceptions, two of which Denver returned for a touchdown, but he also threw for 497 yards and four touchdowns. The Browns offense totaled 552 yards, but its yards-per-play average was equal to the Broncos’ 6.6.
This will be a good bounce-back spot for Denver, which gets a matchup against the usually inefficient Anthony Richardson.
After returning to the starting role with a strong performance agains the Jets, Richardson went into the bye with completion percentages of 39.3% and 50% against the Lions and Patriots.
Denver has a top-five defense on early downs and the Colts have a bottom-10 defense over the first three quarters of games. The Broncos also have the second-best second-half defense in the NFL.
Along with that, the Colts defense ranks in the top 10 in the first and third quarters. That will set up well to defend the Broncos’ scripted plays for Bo Nix.
We rarely get matchups between two teams coming off their bye week, but the under is 40-19 (68%) when that does happen. Eight straight such matchups have hit the under, and they’ve done so by more than 10 points per game.
My Pick: Under 44 (-110)
Broncos vs Colts Betting Trends
NFL Weather
