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College Football Picks Friday for Every Game

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Sep 27, 2025; Chestnut Hill, Massachusetts, USA; California Golden Bears wide receiver Jordan King (4). Credit: Eric Canha-Imagn Images

Contrarian underdogs, projection mismatches and player props comprise six smart picks for college football Friday.

Friday's Week 8 card is solid, and it looks a bit like this:

  • Louisville vs. Miami – 7 p.m. on ESPN
  • Nebraska vs. Minnesota – 8 p.m. on FOX
  • San Jose State vs. Utah State – 9 p.m. on CBS Sports
  • UNC vs. Cal – 10:30 p.m. on ESPN

We've already broken down several ways to bet Saturday's giant slate, including wrong teams favored, a 62-1 moneyline parlay and more.

But if you're interested in high-value picks across every college football game on Friday, stick around. I'm dishing out six best bets (including three at plus-money!) all backed by unique PRO data and running all night long.


College Football Odds Friday: 4 Games, 6 Smart Picks

Louisville vs. Miami Picks Friday

We start the night with a banger when upset-minded Louisville takes on No. 2 Miami.

If you think Louisville has a real shot at tripping up the Hurricanes, you're absolutely right.

Moneyline models accurately called out a couple double-digit 'dogs to win outright last Saturday: Pitt (+320 vs. FSU) and Bowling Green (+320 vs. Toledo).

And that same system detected Louisville as a savvy upset pick for Friday night.

Playbook

The Cardinals fit the perfect type of spread range and market movement for the "Contrarian Underdog" upset model via Action Network Director of Research Evan Abrams.

This system has performed well, delivering consistent win rates and ROI over