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Louisville vs. Indiana Odds & Betting Predictions - December 6, 2025

Louisville at Indiana

7:15 pm • CBS

Louisville Cardinals

18-6
87
87 - 78

Indiana Hoosiers

17-8
78

Louisville at Indiana Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Louisville
18-6
-3.5-110
o162-110
-180
Indiana
17-8
+3.5-110
u162-110
+150
location pinSaturday 7:15 p.m.
December 06, 2025
Gainbridge FieldhouseIndianapolis
Louisville vs. Indiana Expert Picks
Mike McNamara
Mike McNamara
Last 30d: 61-83-1 (-3.5u)
IND +3.5-110
0.28u
Player Prop Savant
Player Prop Savant
Last 30d: 48-52-1 (-5.8u)
Over 160.5-105
1u
Ryan Minion
Ryan Minion
Last 30d: 217-226-4 (+53.7u)
M.Brown o17.5 Pts-130
$1.30
Tickle the Twine
Tickle the Twine
Last 30d: 47-44-1 (-1.9u)
Under 162-110
1u
Ryan Minion
Ryan Minion
Last 30d: 217-226-4 (+53.7u)
LOU -2.5 (1H)-110
$1.00
LOU -4.5-110
$3.00

Louisville vs. Indiana Previews & Analysis

  • Our 4 CBB Best Bets For Saturday article feature image

    Our 4 CBB Best Bets For Saturday

    Action Network Staff•
    Dec 6, 2025 UTC
  • Louisville vs. Indiana: Back More Talented Team article feature image

    Louisville vs. Indiana: Back More Talented Team

    Christian Odjakjian•
    Dec 6, 2025 UTC
  • 2 Spread, O/U Edges Tip at 10 ET article feature image

    2 Spread, O/U Edges Tip at 10 ET

    Alex Kolodziej•
    Dec 6, 2025 UTC
See more NCAAB Coverage Right Arrow

Prop Odds Comparison

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Line Movement Tracker

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Louisville vs. Indiana Public Betting Percentages

Away Logo

Louisville

Public

Home Logo

Indiana

58%

Bets%

42%

Money%

NCAAB Public Betting Right Arrow

Betting Trends

  • Indiana are 4-1 in their last 5 games.
  • Indiana are 3-2 in their last 5 games against the spread
  • Indiana are 5-4 in their road games against the spread
  • The totals have gone OVER in 3 of Indiana' last 5 games
  • The totals have gone OVER in 8 of Indiana' 16 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Indiana		13-128-85-410-73-3
Louisville		12-128-74-59-70-3

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Indiana		12-138-84-510-72-4
Louisville		9-155-104-57-90-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Indiana		17-8N/AN/A13-42-4
Louisville		18-6N/AN/A13-30-3

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Dec 4th@MINNL 64-73-8.5 LU 144.5MINN -463
Nov 29thCOOKW 100-56-29.5 WO 149.5IND -20000
Nov 26thKSUW 86-69-10.5 WU 164.5IND -562
Nov 20thLINWW 73-53-33 LU 155.5-
Nov 16thIWW 69-61-28.5 LU 157.5-

Louisville vs. Indiana Injury Updates

Louisville Injuries

    Indiana Injuries

    • Jason Drake
      G

      Drake is out with foot

      Out

    • Jordan Rayford
      G

      Rayford is out for season with undisclosed

      Out for Season

    See more NCAAB Injuries Right Arrow
    Team Stats

    25-54 (46%)
    Field Goals
    26-63 (41%)
    24-28 (86%)
    Free Throws
    15-19 (79%)
    13-31 (42%)
    3P
    11-34 (32%)
    34
    Rebounds
    27
    15
    Assists
    14
    13
    Turnovers
    12
    9
    Steals
    4
    5
    Blocks
    1
    19
    Fouls
    21

    Louisville vs. Indiana Odds Comparison

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    Louisville at Indiana Team Totals

    MatchupOverUnder
    Louisville
    18-6
    N/A
    N/A
    Indiana
    17-8
    N/A
    N/A