Cardinals vs. Astros Odds & Betting Predictions - March 22, 2026

Cardinals at Astros

4:05 pm • SCHN

St. Louis Cardinals

3

3 - 2

Houston Astros

2

pitcher		team	era	w-l
C.Javier			1.59	0-0
M.McGreevy			2.70	3-0

MatchupOpenSpreadTotalMoneyline
Cardinals 17-9	+1.5	+1.5-190	o7-120	+115
Astros 11-14	u7.5	-1.5+150	u7-102	-135

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Sunday 4:05 p.m.

March 22, 2026

The Ballpark of the Palm BeachesWest Palm Beach

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MLB Public Betting

Astros are 3-2 in their last 5 games.
Astros are 3-2 in their last 5 games against the spread
Astros are 45-36 in their road games against the spread
The totals have gone OVER in 1 of Astros' last 5 games
The totals have gone OVER in 36 of Astros' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Astros	82-80	37-44	45-36	43-60	39-18
Cardinals	80-82	41-40	39-42	25-42	54-40

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Astros	72-83-7	36-43-2	36-40-5	45-56-2	25-27-5
Cardinals	81-74-7	39-39-3	42-35-4	33-29-5	47-45-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Astros	87-75	46-35	41-40	56-47	31-26
Cardinals	78-84	44-37	34-47	33-34	44-50

date	opponent	score	spread	over/under	moneyline
Mar 21st	@NYM	W 7-5	-	-	-
Mar 20th	MIA	L 4-7	-	-	-
Mar 19th	NYM	L 2-6	+1.5 L	O 7	NYM +105
Mar 18th	@STL	L 1-4	-1.5 L	U 7	STL -142
Mar 17th	@PIT	W 10-2	+1.5 W	O 7.5	HOU +124

Hayden Wesneski
RP
Wesneski is out with elbow
Out

Masyn Winn
SS
Masyn Winn (knee) has been scratched Friday.
Out

See more MLB Injuries

PITCHER		PC	IP	K	ER
RM.McGreevy, P		62	5	5	1
RC.Roycroft, P		23	1.1	2	1
RG.Soriano, P		15	1	2	0
RL.Gastelum, P		21	1	3	0

HITTERS	H-AB	R	HR	RBI
1J.Wetherholt, 2B	0-2	0	0	0
1J.Fermin, 1B	1-2	0	0	1
1J.Fermin, LF	1-2	0	0	1
2I.Herrera, C	0-3	0	0	0
2R.Mendoza, 2B	0-2	0	0	0
3A.Burleson, 1B	0-3	0	0	0
3Y.Pozo, C	0-1	0	0	0
4M.Winn, SS	0-1	0	0	0
4B.Moore, PR	0-1	1	0	0
4B.Moore, SS	0-1	1	0	0
5R.Urias, 3B	0-3	0	0	0
6N.Church, LF	1-4	0	0	1
6J. Salazar, 1B	0-0	0	0	0
7J.Walker, RF	2-4	1	1	1
7Y. Pena, RF	0-0	0	0	0
8V.Scott, CF	1-3	0	0	0
9J. Mejia, DH	2-4	1	0	0

PITCHER		PC	IP	K	ER
RC.Javier, P		69	5	2	1
LS.Okert, P		33	1	2	1
RR.Munoz, P		15	1	2	1
RA.Blubaugh, P		31	2	1	0

HITTERS	H-AB	R	HR	RBI
1Z.Cole, RF	1-3	0	0	0
2J.Altuve, 2B	0-2	0	0	0
2B.Matthews, 2B	0-1	0	0	0
3Y.Alvarez, DH	0-2	0	0	0
4J.Meyers, CF	1-3	0	0	0
5T.Trammell, LF	1-3	1	1	1
6C.Biggio, 1B	0-3	0	0	1
6C.Alexander, 1B	0-1	0	0	0
7C.Vazquez, C	1-2	0	0	0
7C.Salazar, C	0-0	0	0	0
8R. Unroe, SS	0-2	0	0	0
9J.Biggers, 3B	1-2	0	0	0
9J.Winkler, 3B	1-1	0	0	0

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MatchupOverUnder
Cardinals 17-9	N/A	N/A
Astros 11-14	N/A	N/A