| Ezequiel Ponce | F | Out | Knee Injury | Knee Injury | Feb 15 |
| Alexander Callens | DEF | Out indefinitely | Hamstring | Hamstring | Apr 11 |
| Domagoj Vida | DEF | Out indefinitely | Abdominal Strain | Abdominal Strain | May 24 |
| Tyrone Mings | DEF | Out | Tyrone Mings is expected to return Mid October 2025 from Ankle injury. | Mings is out with ankle | Oct 2 |
| Boubacar Kamara | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 11 |
| Lucas Digne | DEF | Doubtful | Lucas Digne is Doubtful with Head injury. | Digne is doubtful with head | Sep 14 |
| Pau Torres | DEF | Out indefinitely | Knock | Knock | Apr 4 |
| Youri Tielemans | MID | Out | Youri Tielemans is expected to return Mid October 2025 from Calf injury. | Tielemans is out with calf | Oct 2 |
| Emiliano Buendia | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Dec 27 |
| Ciro Immobile | F | Out | Ciro Immobile is expected to return Early October 2025 from Hamstring Injury. | Immobile is out with hamstring | Sep 18 |
| Tommaso Pobega | MID | Out | Tommaso Pobega is expected to return Early October 2025 from Muscle injury. | Pobega is out with muscle | Sep 18 |
| Juan Miranda | DEF | Out indefinitely | Knock | Knock | Apr 11 |
| Joaquin Sosa | DEF | Out | Joaquín Sosa is expected to return Early October 2025 from Muscle injury. | Sosa is out with muscle | Sep 6 |
| Joao Moutinho | MID | Out | Ankle/Foot Injury | Ankle/Foot Injury | Aug 20 |
| Rodrigo Zalazar | MID | Out indefinitely | Metatarsal Fracture | Metatarsal Fracture | Jan 30 |
| Victor Gomez | DEF | Out | Suspended | Suspended | May 7 |
| Noah Jean Holm | F | Out | Back Injury | Back Injury | Apr 11 |
| Markus Haaland | MID | Out indefinitely | Markus Haaland will not play due to National team. | Haaland is injured with unknown | Sep 29 |
| Sakarias Opsahl | MID | Out | Sakarias Opsahl is expected to return Late October 2025 from Foot injury. | Opsahl is out with foot | Oct 1 |
| Joachim Soltvedt | MID | Out | Joachim Soltvedt is expected to return Mid October 2025 from Knock injury. | Soltvedt is out with knock injury | Oct 1 |
| Jonas Tviberg Torsvik | DEF | Out | Jonas Torsvik is expected to return Mid October 2025 from Knock injury. | Torsvik is out with knock injury | Oct 1 |
| Marcos Alonso | DEF | Out indefinitely | Knock | Knock | Sep 5 |
| Franco Cervi | F | Out | Suspended | Suspended | Oct 2 |
| Carles Perez | F | Out indefinitely | Carles Pérez is Unknown with Knee injury. | Perez is injured with knee | Sep 30 |
| Luca De La Torre | MID | Out | Hamstring | Hamstring | Nov 22 |
| Manu Sanchez | MID | Out indefinitely | Hamstring | Hamstring | May 12 |
| Ilaix Moriba | MID | Out indefinitely | Hamstring | Hamstring | Dec 28 |
| Sergio Carreira | DEF | Out | Sergio Carreira is expected to return Mid October 2025 from Ankle injury. | Carreira is out with ankle | Sep 29 |
| Kasper Schmeichel | GK | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Aug 14 |
| Cameron Carter-Vickers | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Oct 25 |
| Arber Hoxha | F | Doubtful | Arbër Hoxha is Doubtful with Thigh injury. | Hoxha is doubtful with thigh | Sep 29 |
| Luka Stojkovic | MID | Suspended | Luka Stojkovic is serving a suspension for Red card. | Stojkovic is suspended with red card | Sep 22 |
| Denys Popov | DEF | Out indefinitely | Denys Popov is Unknown with Unknown. | Popov is injured with unknown | Oct 1 |
| Xherdan Shaqiri | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Dec 20 |
| Flavius Daniliuc | DEF | Out | Suspended | Suspended | Aug 7 |
| Ibrahim Salah | F | Doubtful | None | Salah is doubtful | May 16 |
| Marin Jakolis | F | Out indefinitely | Knock | Knock | Feb 28 |
| Pablo Rosario | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Feb 11 |
| Luuk De Jong | F | Out indefinitely | Hand Injury | Hand Injury | Jun 5 |
| William Gomes | F | Doubtful | William Gomes is Doubtful with Unknown. | Gomes is doubtful with unknown | Sep 19 |
| Pepe | F | Day to day | Pepê is Day to day with Eye injury. | Pepe is day-to-day with eye | Sep 12 |
| Cyrille Bayala | F | Out | Suspended | Suspended | Apr 2 |
| Yoann Cathline | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Feb 6 |
| Marko Arnautovic | F | Out | Foot Injury | Foot Injury | Feb 4 |
| Milos Veljkovic | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 3 |
| Nemanja Radonjic | F | Out indefinitely | None | Radonjic is injured | Jul 27 |
| Caglar Soyuncu | DEF | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Dec 6 |
| Diego Carlos | DEF | Out indefinitely | None | Carlos is injured | Jan 23 |
| Nelson Semedo | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Aug 15 |
| Fred | MID | Out | Groin/Pelvis Injury | Groin/Pelvis Injury | Apr 28 |
| Cengiz Under | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Apr 25 |
| Edson Alvarez | MID | Out | Suspended | Suspended | Nov 10 |
| Kerem Akturkoglu | F | Out indefinitely | Hamstring | Hamstring | Apr 10 |
| Cenk Tosun | F | Out | Cenk Tosun is expected to return Early September 2025 from Groin injury. | Tosun is out with groin | Aug 26 |
| Mert Hakan Yandas | MID | Out | Mert Hakan Yandas is expected to return Early September 2025 from Foot injury. | Yandas is out with foot | Aug 26 |
| Cyle Larin | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Mar 8 |
| Jordan Lotomba | DEF | Out | Ankle/Foot Injury | Ankle/Foot Injury | Apr 11 |
| Goncalo Borges | F | Out indefinitely | Gonçalo Borges will not play due to Personal reason. | Borges is injured with unknown | Sep 17 |
| Vincenzo Grifo | MID | Out indefinitely | Virus | Virus | Apr 18 |
| Florian Muller | GK | Out indefinitely | Illness | Illness | Oct 26 |
| Merlin Rohl | MID | Out | Merlin Röhl is expected to return Early October 2025 from Hip injury. | Rohl is out with hip | Sep 26 |
| Junya Ito | MID | Out | Suspended | Suspended | Oct 16 |
| Konstantinos Karetsas | MID | Out | Konstantinos Karetsas is expected to return Early October 2025 from Back injury. | Karetsas is out with back | Sep 20 |
| Tobias Lawal | GK | Out | Tobias Lawal is expected to return Early November 2025 from Knee injury. | Lawal is out with knee | Oct 2 |
| Yira Sor | MID | Day to day | Yira Sor is Day to day with Unknown. | Sor is day-to-day with unknown | Sep 20 |
| Olivier Giroud | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 11 |
| Nabil Bentaleb | MID | Out indefinitely | Back Injury | Back Injury | Jan 2 |
| Thomas Meunier | DEF | Out indefinitely | Back Injury | Back Injury | Apr 10 |
| Andre Gomes | MID | Out | Suspended | Suspended | Apr 2 |
| Chancel Mbemba | DEF | Out | Knee Injury | Knee Injury | Jan 13 |
| Alexsandro Ribeiro | DEF | Out | Alexsandro Ribeiro is expected to return Mid October 2025 from Thigh injury. | Ribeiro is out with thigh | Oct 1 |
| Ousmane Toure | DEF | Out indefinitely | Toure, Ousmane: missing - injured | Toure is injured | Aug 23 |
| Kwadwo Duah | F | Out indefinitely | Kwadwo Duah is Unknown with Unknown. | Duah is injured with unknown | Sep 23 |
| Ainsley Maitland-Niles | MID | Out indefinitely | Virus | Virus | Jan 3 |
| Corentin Tolisso | MID | Out | Calf/Shin Injury | Calf/Shin Injury | Mar 4 |
| Remy Descamps | GK | Out | Remy Descamps is expected to return Mid October 2025 from Wrist injury. | Descamps is out with wrist | Sep 16 |
| Orel Mangala | MID | Out indefinitely | None | Mangala is injured | Feb 13 |
| Duje Caleta-Car | DEF | Out | Virus | Virus | Aug 14 |
| Martin Satriano | F | Out indefinitely | None | Satriano is injured | Feb 13 |
| Abner Vinicius | DEF | Out indefinitely | None | Vinicius is injured | Feb 17 |
| Clinton Mata | MID | Doubtful | None | Mata is doubtful | May 16 |
| Johan Dahlin | GK | Doubtful | Johan Dahlin is Doubtful with Cruciate ligament injury. | Dahlin is doubtful with knee | Oct 2 |
| Otto Rosengren | MID | Suspended | Otto Rosengren is serving a suspension for Yellow cards. | Rosengren is suspended with yellow cards | Sep 23 |
| Arnor Sigurdsson | MID | Out | Arnór Sigurdsson is expected to return Mid October 2025 from Thigh injury. | Sigurdsson is out with thigh | Sep 17 |
| Dante | DEF | Out | Dante is expected to return Late October 2025 from Knee injury. | Dante is out with knee | Oct 1 |
| Hichem Boudaoui | MID | Out | Hichem Boudaoui is expected to return in About 1-2 weeks from Hip injury. | Boudaoui is out with hip | Oct 1 |
| Jonathan Clauss | DEF | Out | Groin Strain | Groin Strain | Jan 24 |
| Youssouf Ndayishimiye | MID | Out indefinitely | Knock | Knock | Apr 3 |
| Mattia Viti | DEF | Out indefinitely | None | Viti is injured | Feb 13 |
| Issiaga Camara | MID | Suspended | Issiaga Camara is serving a suspension for Yellow cards. | Camara is suspended with yellow cards | Sep 29 |
| Ola Aina | DEF | Out | Ola Aina is expected to return Early January 2026 from Hamstring Injury. | Aina is out with hamstring | Sep 18 |
| Oleksandr Zinchenko | DEF | Out | Oleksandr Zinchenko is expected to return Late October 2025 from Muscle injury. | Zinchenko is out with muscle | Oct 1 |
| Willy Boly | DEF | Out | Hamstring | Hamstring | Apr 11 |
| Omar Richards | DEF | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Apr 11 |
| Cuiabano | DEF | Suspended | Cuiabano is serving a suspension for Yellow cards. | Cuiabano is suspended with yellow cards | Oct 2 |
| Giulian Biancone | DEF | Out indefinitely | Knee Injury | Knee Injury | Apr 11 |
| Jonjoe Kenny | DEF | Out indefinitely | Concussion | Concussion | Feb 6 |
| Dejan Lovren | DEF | Out | Concussion | Concussion | Apr 11 |
| Rahman Baba | DEF | Out indefinitely | Knee Injury | Knee Injury | Dec 8 |
| Soualiho Meite | MID | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Dec 11 |
| Renato Sanches | MID | Out | Groin/Pelvis Injury | Groin/Pelvis Injury | Mar 13 |
| Pedro Chirivella | MID | Out indefinitely | Groin Strain | Groin Strain | Apr 11 |
| Dimitris Limnios | MID | Out indefinitely | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Feb 13 |
| Erik Palmer-Brown | DEF | Out indefinitely | Knock | Knock | Dec 20 |
| Cyriel Dessers | F | Out | Cyriel Dessers is expected to return Mid September 2025 from Knee injury. | Dessers is out with knee | Aug 26 |
| Jack Butland | GK | Out indefinitely | Hand Injury | Hand Injury | Nov 7 |
| Bojan Miovski | F | Out indefinitely | None | Miovski is injured | May 24 |
| Hector Bellerin | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Oct 29 |
| Adrian | GK | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Jan 3 |
| Diego Llorente | DEF | Out | Diego Llorente is expected to return Mid October 2025 from Muscle injury. | Llorente is out with muscle | Sep 29 |
| Pablo Fornals | MID | Out indefinitely | None | Fornals is injured | Jan 20 |
| Junior Firpo | DEF | Out | Knee Injury | Knee Injury | Sep 3 |
| Cucho Hernandez | F | Out | Thigh Muscle Strain | Thigh Muscle Strain | May 22 |
| Abde Ezzalzouli | F | Out | Suspended | Suspended | Feb 12 |
| Marc Bartra | DEF | Out | Marc Bartra is expected to return Mid October 2025 from Muscle injury. | Bartra is out with muscle | Sep 29 |
| Isco | MID | Out indefinitely | None | Isco is injured | Aug 15 |
| Paulo Dybala | F | Out | Paulo Dybala is expected to return Mid October 2025 from Leg injury. | Dybala is out with leg | Sep 29 |
| Angelino | DEF | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Sep 13 |
| Leon Bailey | F | Out | Ankle/Foot Injury | Ankle/Foot Injury | May 15 |
| Kostas Tsimikas | DEF | Out | Knock | Knock | Aug 15 |
| Tammy Abraham | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 8 |
| Zeki Celik | DEF | Out | Suspended | Suspended | Feb 20 |
| Marash Kumbulla | DEF | Out | Marash Kumbulla is expected to return Mid October 2025 from Hamstring Injury. | Kumbulla is out with hamstring | Sep 29 |
| Akim Zedadka | DEF | Doubtful | None | Zedadka is doubtful | Aug 16 |
| Stefan Lainer | DEF | Out indefinitely | Knock | Knock | Nov 11 |
| Yorbe Vertessen | F | Doubtful | Yorbe Vertessen is Doubtful with Knock injury. | Vertessen is doubtful with maintenance | Sep 12 |
| Anrie Chase | DEF | Out indefinitely | None | Chase is injured | Mar 7 |
| Vinicius Tobias | DEF | Doubtful | None | Tobias is doubtful | Feb 9 |
| Vladimir Weiss | MID | Suspended | Vladimir Weiss is serving a suspension for Red card. | Weiss is suspended with red card | Sep 26 |
| Oliver Christensen | GK | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | Mar 6 |
| Julian Chabot | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Nov 3 |
| Ermedin Demirovic | F | Out | Suspended | Suspended | Apr 11 |
| Tiago Tomas | F | Out indefinitely | Knock | Knock | Feb 27 |
| Justin Diehl | F | Out | Justin Diehl is expected to return in About a week from Muscle injury. | Diehl is out with muscle | Sep 21 |
| Yannik Keitel | MID | Out indefinitely | None | Keitel is injured | May 16 |
| Finn Jeltsch | DEF | Out | Finn Jeltsch is expected to return Late October 2025 from Groin injury. | Jeltsch is out with groin | Sep 26 |
| Edimilson Fernandes | DEF | Out indefinitely | Illness | Illness | Sep 19 |
| Saidy Janko | DEF | Out indefinitely | Hamstring | Hamstring | Feb 5 |
| Sergio Cordova | F | Out indefinitely | None | Cordova is injured | Mar 31 |
