| Ezequiel Ponce | F | Out | Knee Injury | Knee Injury | Feb 15 |
| Alexander Callens | DEF | Out indefinitely | Hamstring | Hamstring | Apr 11 |
| Domagoj Vida | DEF | Out indefinitely | Abdominal Strain | Abdominal Strain | May 24 |
| Boubacar Kamara | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 11 |
| Pau Torres | DEF | Out indefinitely | Knock | Knock | Apr 4 |
| Leon Bailey | F | Out | Ankle/Foot Injury | Ankle/Foot Injury | May 15 |
| Tammy Abraham | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 8 |
| Juan Miranda | DEF | Out indefinitely | Knock | Knock | Apr 11 |
| Joao Moutinho | MID | Out | Ankle/Foot Injury | Ankle/Foot Injury | Aug 20 |
| Rodrigo Zalazar | MID | Out indefinitely | Metatarsal Fracture | Metatarsal Fracture | Jan 30 |
| Sandro Vidigal | F | Doubtful | Sandro Vidigal is Doubtful with Unknown. | Vidigal is doubtful with unknown | Jan 13 |
| Amine El Ouazzani | F | Out | Amine El Ouazzani is expected to return in About a week from Broken foot. | El Ouazzani is out with foot | Mar 11 |
| Noah Jean Holm | F | Out | Back Injury | Back Injury | Apr 11 |
| Rabbi Matondo | MID | Out | Rabbi Matondo is expected to return Early January 2026 from Knee injury. | Matondo is out with knee | Dec 21 |
| Niklas Castro | F | Out | Niklas Castro is expected to return Early November 2025 from Thigh injury. | Castro is out with thigh | Oct 19 |
| Denzel De Roeve | DEF | Out | Denzel De Roeve is expected to return Mid July 2026 from Unknown. | De Roeve is out with unknown | May 16 |
| Mathias Dyngeland | GK | Out | Matias Dyngeland is expected to return Mid July 2026 from Thigh injury. | Dyngeland is out with thigh | May 16 |
| Markus Haaland | MID | Out indefinitely | Markus Haaland will not play due to National team. | Haaland is injured with unknown | Sep 29 |
| Jakob Lungi Sorensen | MID | Out | Jakob Sørensen is expected to return Early July 2026 from Ankle injury. | Lungi Sorensen is out with ankle | May 20 |
| Thore Pedersen | DEF | Suspended | Thore Pedersen is serving a suspension for Yellow cards. | Pedersen is suspended with yellow cards | Oct 27 |
| Joachim Soltvedt | MID | Out | Joachim Soltvedt is expected to return Mid October 2025 from Knock injury. | Soltvedt is out with knock injury | Oct 1 |
| Marcos Alonso | DEF | Out indefinitely | Knock | Knock | Sep 5 |
| Franco Cervi | F | Out | Suspended | Suspended | Oct 2 |
| Ilaix Moriba | MID | Out indefinitely | Hamstring | Hamstring | Dec 28 |
| Alex Oxlade-Chamberlain | MID | Out | Thigh Muscle Rupture | Thigh Muscle Rupture | Oct 29 |
| Kasper Schmeichel | GK | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Aug 14 |
| Cameron Carter-Vickers | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Oct 25 |
| Ivan Filipovic | GK | Out | Ivan Filipovic is expected to return in A few weeks from Thigh injury. | Filipovic is out with thigh | Jan 29 |
| Arber Hoxha | F | Out | Arbër Hoxha is expected to return in A few weeks from Back injury. | Hoxha is out with back | Feb 26 |
| Mateo Lisica | F | Out | Mateo Lisica is expected to return in A few weeks from Back injury. | Lisica is out with back | Mar 7 |
| Noa Mikic | DEF | Out | Noa Mikic will not play due to National team. | Mikic is out with with national team | Feb 12 |
| Josip Misic | MID | Out | Josip Misic is expected to return in About 1-2 weeks from Knock injury. | Misic is out with knock injury | Dec 21 |
| Kevin Theophile-Catherine | DEF | Out indefinitely | Kevin Theophile Catherine is Unknown with Unknown. | Theophile-Catherine is injured with unknown | Apr 26 |
| Xherdan Shaqiri | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Dec 20 |
| Flavius Daniliuc | DEF | Out | Suspended | Suspended | Aug 7 |
| Ibrahim Salah | F | Doubtful | None | Salah is doubtful | May 16 |
| Kaio Eduardo Eduardo | F | Out for season | Kaio Eduardo is Out for season with Cruciate ligament injury. | Eduardo is out for season with knee | Mar 3 |
| Metinho | MID | Out | Metinho is Back in training with Leg injury. | Metinho is out with leg | Feb 21 |
| Dominik Robin Schmid | MID | Suspended | Dominik Schmid is serving a suspension for Yellow cards. | Schmid is suspended with yellow cards | May 3 |
| Keigo Tsunemoto | DEF | Out indefinitely | Keigo Tsunemoto is Unknown with Ankle injury. | Tsunemoto is injured with ankle | Mar 22 |
| Finn van Breemen | DEF | Out indefinitely | Finn van Breemen is Unknown with Unknown. | van Breemen is injured with unknown | May 14 |
| Evann Senaya | F | Out | Evann Senaya is expected to return in A few weeks from Ankle injury. | Senaya is out with ankle | May 14 |
| Pedro Bravo | MID | Suspended | Pedro Bravo is serving a suspension for Yellow cards. | Bravo is suspended with yellow cards | Apr 13 |
| Paulinho | DEF | Out | Paulinho is expected to return Early June 2026 from Unknown. | Paulinho is out with unknown | May 17 |
| Alamara Viriato Djabi | MID | Day to day | Alamara Djabi is expected to return in A few days from Unknown. | Viriato Djabi is day-to-day with unknown | May 19 |
| Arlet Ze | F | Day to day | Junior Zé is Day to day with Unknown. | Ze is day-to-day with unknown | May 17 |
| Marin Jakolis | F | Out indefinitely | Knock | Knock | Feb 28 |
| Pablo Rosario | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Feb 11 |
| Luuk De Jong | F | Out indefinitely | Hand Injury | Hand Injury | Jun 5 |
| Rodrigo Mora | MID | Doubtful | Rodrigo Mora is Doubtful with Thigh injury. | Mora is doubtful with thigh | Apr 6 |
| Oskar Pietuszewski | MID | Out | Oskar Pietuszewski will not play due to Other. | Pietuszewski is out with unknown | Apr 14 |
| Andre Oliveira | MID | Out | Andre Oliveira is expected to return Late November 2026 from Cruciate ligament injury. | Oliveira is out with knee | Apr 8 |
| William Gomes | F | Suspended | William Gomes is serving a suspension for Yellow cards. | Gomes is suspended with yellow cards | Apr 6 |
| Francisco Moura | DEF | Suspended | Francisco Moura is serving a suspension for Yellow cards. | Moura is suspended with yellow cards | Feb 13 |
| Pepe | F | Day to day | Pepê is Day to day with Eye injury. | Pepe is day-to-day with eye | Sep 12 |
| Zaidu Sanusi | DEF | Day to day | Zaidu Sanusi is Day to day with Overload. | Sanusi is day-to-day with rest | May 1 |
| Cyrille Bayala | F | Out | Suspended | Suspended | Apr 2 |
| Yoann Cathline | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Feb 6 |
| Jaygo van Ommeren | MID | Doubtful | Jaygo van Ommeren is Doubtful with Back injury. | van Ommeren is doubtful with back | Apr 10 |
| Emirhan Demircan | F | Day to day | Emirhan Demircan is Day to day with Hamstring Injury. | Demircan is day-to-day with hamstring | May 21 |
| Matisse Didden | MID | Suspended | Matisse Didden is serving a suspension for Yellow/red card. | Didden is suspended with yellow/red card | Apr 27 |
| David Min | F | Day to day | David Min is expected to return in A few days from Unknown. | Min is day-to-day with unknown | Dec 21 |
| Niklas Vesterlund | DEF | Out | Niklas Vesterlund is expected to return Late March 2026 from Groin injury. | Vesterlund is out with groin | Mar 14 |
| Milos Veljkovic | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 3 |
| Matteo Guendouzi | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 2 |
| Fred | MID | Out | Groin/Pelvis Injury | Groin/Pelvis Injury | Apr 28 |
| Sidiki Cherif | F | Out | Sidiki Cherif is expected to return in About 1-2 weeks from Ankle injury. | Cherif is out with ankle | Jan 30 |
| Talisca | MID | Out | Talisca is expected to return Mid March 2026 from Leg injury. | Talisca is out with leg | Feb 24 |
| Nene Dorgeles | F | Out | Dorgeles Nene is expected to return Mid July 2026 from Hernia. | Nene is out with hernia | May 18 |
| Jordan Lotomba | DEF | Out | Ankle/Foot Injury | Ankle/Foot Injury | Apr 11 |
| Timon Wellenreuther | GK | Suspended | Timon Wellenreuther is serving a suspension for Yellow cards. | Wellenreuther is suspended with yellow cards | Feb 9 |
| Goncalo Borges | F | Out indefinitely | Gonçalo Borges will not play due to Personal reason. | Borges is injured with unknown | Sep 17 |
| Leo Sauer | F | Doubtful | Leo Sauer is Doubtful with Hamstring Injury. | Sauer is doubtful with hamstring | Apr 4 |
| Shaqueel van Persie | F | Day to day | Shaqueel Van Persie is expected to return in A few days from Knee injury. | van Persie is day-to-day with knee | Mar 14 |
| Mats Deijl | DEF | Out | Mats Deijl will not play due to Other. | Deijl is out with unknown | Jan 29 |
| Vincenzo Grifo | MID | Out indefinitely | Virus | Virus | Apr 18 |
| Noah Adedeji-Sternberg | F | Doubtful | Noah Adedeji-Sternberg is Doubtful with Muscle injury. | Adedeji-Sternberg is doubtful with muscle | Feb 12 |
| Ibrahima Sory Bangoura | MID | Suspended | Ibrahima Sory Bangoura is serving a suspension for Yellow cards. | Bangoura is suspended with yellow cards | Apr 7 |
| Daan Heymans | MID | Out | Daan Heymans is expected to return Early June 2026 from Hamstring Injury. | Heymans is out with hamstring | May 18 |
| Bryan Heynen | MID | Suspended | Bryan Heynen is serving a suspension for Yellow cards. | Heynen is suspended with yellow cards | Mar 2 |
| Konstantinos Karetsas | MID | Out | Konstantinos Karetsas is expected to return Early June 2026 from Ankle injury. | Karetsas is out with ankle | May 18 |
| Tobias Lawal | GK | Out | Tobias Lawal is expected to return in About a week from Knee injury. | Lawal is out with knee | Nov 1 |
| Matte Smets | DEF | Suspended | Matte Smets is serving a suspension for Yellow cards. | Smets is suspended with yellow cards | Apr 7 |
| Yira Sor | MID | Day to day | Yira Sor is Day to day with Unknown. | Sor is day-to-day with unknown | Sep 20 |
| Thibo Baeten | F | Suspended | Thibo Baeten is serving a suspension for Red card. | Baeten is suspended with red card | Feb 16 |
| Pim Saathof | MID | Out | Pim Saathof will not play due to Other. | Saathof is out with unknown | Jan 29 |
| Oskar Sivertsen | F | Suspended | Oskar Sivertsen is serving a suspension for Yellow/red card. | Sivertsen is suspended with yellow/red card | May 4 |
| Soren Tengstedt | F | Out | Sören Tengstedt is Back in training with Muscle injury. | Tengstedt is out with muscle | Jan 11 |
| Olivier Giroud | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 11 |
| Nabil Bentaleb | MID | Out indefinitely | Back Injury | Back Injury | Jan 2 |
| Ainsley Maitland-Niles | MID | Out indefinitely | Virus | Virus | Jan 3 |
| Corentin Tolisso | MID | Out | Calf/Shin Injury | Calf/Shin Injury | Mar 4 |
| Orel Mangala | MID | Out indefinitely | None | Mangala is injured | Feb 13 |
| Abner Vinicius | DEF | Out indefinitely | None | Vinicius is injured | Feb 17 |
| Yanis Karabelyov | MID | Doubtful | Yanis Karabelyov is Doubtful with Knee injury. | Karabelyov is doubtful with knee | Apr 13 |
| Busanello | DEF | Doubtful | Busanello is Doubtful with Thigh injury. | Busanello is doubtful with thigh | Apr 12 |
| Anders Christiansen | MID | Doubtful | Anders Christiansen is Doubtful with Thigh injury. | Christiansen is doubtful with thigh | Apr 13 |
| Johan Dahlin | GK | Out | Johan Dahlin is expected to return in About a week from Illness. | Dahlin is out with illness | May 19 |
| Otto Rosengren | MID | Suspended | Otto Rosengren is serving a suspension for Yellow cards. | Rosengren is suspended with yellow cards | May 11 |
| Arnor Sigurdsson | MID | Out | Arnór Sigurdsson is expected to return Early January 2026 from Knee injury. | Sigurdsson is out with knee | Dec 21 |
| Jonathan Clauss | DEF | Out | Groin Strain | Groin Strain | Jan 24 |
| Youssouf Ndayishimiye | MID | Out indefinitely | Knock | Knock | Apr 3 |
| Willy Boly | DEF | Out | Hamstring | Hamstring | Apr 11 |
| Giulian Biancone | DEF | Out indefinitely | Knee Injury | Knee Injury | Apr 11 |
| Jonjoe Kenny | DEF | Out indefinitely | Concussion | Concussion | Feb 6 |
| Dejan Lovren | DEF | Out | Concussion | Concussion | Apr 11 |
| Rahman Baba | DEF | Out indefinitely | Knee Injury | Knee Injury | Dec 8 |
| Soualiho Meite | MID | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Dec 11 |
| Moussa Sissoko | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Sep 8 |
| Renato Sanches | MID | Out | Groin/Pelvis Injury | Groin/Pelvis Injury | Mar 13 |
| Pedro Chirivella | MID | Out indefinitely | Groin Strain | Groin Strain | Apr 11 |
| Erik Palmer-Brown | DEF | Out indefinitely | Knock | Knock | Dec 20 |
| Cyriel Dessers | F | Out | Cyriel Dessers is expected to return Mid September 2025 from Knee injury. | Dessers is out with knee | Aug 26 |
| Andrews Tetteh | F | Out | Andreas Tetteh is expected to return in About 1-2 weeks from Muscle injury. | Tetteh is out with muscle | May 17 |
| Jack Butland | GK | Out indefinitely | Hand Injury | Hand Injury | Nov 7 |
| Bailey Rice | MID | Out | Bailey Rice is expected to return Mid May 2026 from Muscle injury. | Rice is out with muscle | May 1 |
| Dujon Sterling | DEF | Out | Dujon Sterling is expected to return Mid February 2026 from Muscle injury. | Sterling is out with muscle | Feb 1 |
| Bojan Miovski | F | Out indefinitely | None | Miovski is injured | May 24 |
| Tuur Rommens | DEF | Out | Tuur Rommens is expected to return in A few weeks from Muscle injury. | Rommens is out with muscle | Apr 12 |
| Hector Bellerin | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Oct 29 |
| Adrian | GK | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Jan 3 |
| Aitor Ruibal | F | Out | Aitor Ruibal García is expected to return Early August 2026 from Knee injury. | Ruibal is out with knee | May 15 |
| Junior Firpo | DEF | Out | Júnior Firpo is expected to return Early May 2026 from Muscle injury. | Firpo is out with muscle | Apr 19 |
| Sergi Altimira | MID | Out | Sergi Altimira is expected to return Early June 2026 from Calf injury. | Altimira is out with calf | May 19 |
| Angelino | DEF | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Sep 13 |
| Kostas Tsimikas | DEF | Out | Knock | Knock | Aug 15 |
| Akim Zedadka | DEF | Doubtful | None | Zedadka is doubtful | Aug 16 |
| Stefan Lainer | DEF | Out indefinitely | Knock | Knock | Nov 11 |
| Anrie Chase | DEF | Out indefinitely | None | Chase is injured | Mar 7 |
| Moussa Kounfolo Yeo | MID | Out | Moussa Yeo is expected to return in About 1-2 weeks from Knee injury. | Yeo is out with knee | Apr 4 |
| Vinicius Tobias | DEF | Doubtful | None | Tobias is doubtful | Feb 9 |
| Jusuf Gazibegovic | DEF | Doubtful | Jusuf Gazibegovic is Doubtful with Thigh injury. | Gazibegovic is doubtful with thigh | Mar 1 |
| Leon Grgic | F | Out | Leon Grgic is expected to return in A few weeks from Ankle injury. | Grgic is out with ankle | Dec 8 |
| Seedy Jatta | F | Doubtful | Seedy Jatta is Doubtful with Illness. | Jatta is doubtful with illness | May 10 |
| Otar Kiteishvili | MID | Out | Otar Kiteishvili is expected to return in A few weeks from Muscle injury. | Kiteishvili is out with muscle | May 10 |
| Dimitri Lavalee | DEF | Out for season | Dimitri Lavalée is Out for season with Knee injury. | Lavalee is out for season with knee | Dec 3 |
| Arjan Malic | MID | Out | Arjan Malic is expected to return in About 1-2 weeks from Muscle injury. | Malic is out with muscle | Apr 26 |
| Filip Rozga | MID | Out | Filip Rozga is expected to return in A few weeks from Muscle injury. | Rozga is out with muscle | Apr 12 |
| Julian Chabot | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Nov 3 |
| Tiago Tomas | F | Out indefinitely | Knock | Knock | Feb 27 |
| Salim Fago Lawal | F | Out | Salim Fago Lawal is expected to return Mid May 2026 from Physical discomfort. | Lawal is out with soreness | May 3 |
| Edimilson Fernandes | DEF | Out indefinitely | Illness | Illness | Sep 19 |
| Saidy Janko | DEF | Out indefinitely | Hamstring | Hamstring | Feb 5 |
| Gregory Wuthrich | DEF | Suspended | Gregory Wüthrich is serving a suspension for Yellow cards. | Wuthrich is suspended with yellow cards | May 4 |
| Loris Benito | DEF | Suspended | Loris Benito is serving a suspension for Yellow cards. | Benito is suspended with yellow cards | Apr 13 |
| Olivier Mambwa | DEF | Suspended | Olivier Mambwa is serving a suspension for Red card. | Mambwa is suspended with red card | Jan 31 |
