| Ezequiel Ponce | F | Out | Knee Injury | Knee Injury | Feb 15 |
| Alexander Callens | DEF | Out indefinitely | Hamstring | Hamstring | Apr 11 |
| Domagoj Vida | DEF | Out indefinitely | Abdominal Strain | Abdominal Strain | May 24 |
| Boubacar Kamara | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 11 |
| Lucas Digne | DEF | Doubtful | Lucas Digne is Doubtful with Head injury. | Digne is doubtful with head | Sep 14 |
| Pau Torres | DEF | Out indefinitely | Knock | Knock | Apr 4 |
| Leon Bailey | F | Out | Ankle/Foot Injury | Ankle/Foot Injury | May 15 |
| Youri Tielemans | MID | Out | Youri Tielemans is expected to return Late March 2026 from Ankle injury. | Tielemans is out with ankle | Jan 27 |
| Tammy Abraham | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 8 |
| Emiliano Buendia | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Dec 27 |
| Harvey Elliott | MID | Out | Harvey Elliott is expected to return Mid March 2026 from Knock injury. | Elliott is out with knock injury | Feb 26 |
| John McGinn | MID | Out | John McGinn is expected to return Mid April 2026 from Knee injury. | McGinn is out with knee | Jan 28 |
| Andres Garcia | MID | Doubtful | Andrés García is Doubtful with Hamstring Injury. | Garcia is doubtful with hamstring | Feb 26 |
| Charalampos Lykogiannis | DEF | Out | Charalampos Lykogiannis is expected to return Mid March 2026 from Muscle injury. | Lykogiannis is out with muscle | Feb 27 |
| Juan Miranda | DEF | Out indefinitely | Knock | Knock | Apr 11 |
| Joao Moutinho | MID | Out | Ankle/Foot Injury | Ankle/Foot Injury | Aug 20 |
| Rodrigo Zalazar | MID | Out indefinitely | Metatarsal Fracture | Metatarsal Fracture | Jan 30 |
| Victor Gomez | DEF | Out | Suspended | Suspended | May 7 |
| Sandro Vidigal | F | Doubtful | Sandro Vidigal is Doubtful with Unknown. | Vidigal is doubtful with unknown | Jan 13 |
| Vitor Carvalho | MID | Doubtful | Vitor Carvalho is Doubtful with Hip injury. | Carvalho is doubtful with hip | Feb 27 |
| Amine El Ouazzani | F | Out | Amine El Ouazzani is expected to return Mid March 2026 from Broken foot. | El Ouazzani is out with foot | Dec 27 |
| Sikou Niakate | DEF | Doubtful | Sikou Niakaté is Doubtful with Muscle injury. | Niakate is doubtful with muscle | Feb 11 |
| Adrian Leon Barisic | DEF | Out | Adrian Leon Barisic will not play due to Other. | Barisic is out with unknown | Jan 29 |
| Demir Tiknaz | MID | Out | Ege Tiknaz will not play due to Other. | Tiknaz is out with unknown | Jan 29 |
| Noah Jean Holm | F | Out | Back Injury | Back Injury | Apr 11 |
| Niklas Castro | F | Out | Niklas Castro is expected to return Early November 2025 from Thigh injury. | Castro is out with thigh | Oct 19 |
| Markus Haaland | MID | Out indefinitely | Markus Haaland will not play due to National team. | Haaland is injured with unknown | Sep 29 |
| Thore Pedersen | DEF | Suspended | Thore Pedersen is serving a suspension for Yellow cards. | Pedersen is suspended with yellow cards | Oct 27 |
| Joachim Soltvedt | MID | Out | Joachim Soltvedt is expected to return Mid October 2025 from Knock injury. | Soltvedt is out with knock injury | Oct 1 |
| Marcos Alonso | DEF | Out indefinitely | Knock | Knock | Sep 5 |
| Franco Cervi | F | Out | Suspended | Suspended | Oct 2 |
| Ilaix Moriba | MID | Out indefinitely | Hamstring | Hamstring | Dec 28 |
| Pablo Duran | F | Out | Pablo Durán is expected to return Late March 2026 from Knee injury. | Duran is out with knee | Feb 23 |
| Hugo Sotelo | MID | Out | Hugo Sotelo is expected to return Mid March 2026 from Ankle injury. | Sotelo is out with ankle | Feb 27 |
| Andres Antanon | MID | Out | Andres Antanon is expected to return Mid March 2026 from Muscle injury. | Antanon is out with muscle | Feb 27 |
| Alex Oxlade-Chamberlain | MID | Out | Thigh Muscle Rupture | Thigh Muscle Rupture | Oct 29 |
| Kasper Schmeichel | GK | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Aug 14 |
| Cameron Carter-Vickers | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Oct 25 |
| Monsef Bakrar | F | Out indefinitely | Monsef Bakrar will not play due to National team. | Bakrar is injured with unknown | Dec 17 |
| Ivan Filipovic | GK | Out | Ivan Filipovic is expected to return in A few weeks from Thigh injury. | Filipovic is out with thigh | Jan 29 |
| Arber Hoxha | F | Out | Arbër Hoxha is expected to return in A few weeks from Back injury. | Hoxha is out with back | Feb 26 |
| Noa Mikic | DEF | Out | Noa Mikic will not play due to National team. | Mikic is out with with national team | Feb 12 |
| Josip Misic | MID | Out | Josip Misic is expected to return in About 1-2 weeks from Knock injury. | Misic is out with knock injury | Dec 21 |
| Luka Stojkovic | MID | Suspended | Luka Stojkovic is serving a suspension for Red card. | Stojkovic is suspended with red card | Sep 22 |
| Xherdan Shaqiri | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Dec 20 |
| Flavius Daniliuc | DEF | Out | Suspended | Suspended | Aug 7 |
| Ibrahim Salah | F | Doubtful | None | Salah is doubtful | May 16 |
| Kaio Eduardo Eduardo | F | Suspended | Kaio Eduardo is serving a suspension for Yellow cards. | Eduardo is suspended with yellow cards | Feb 21 |
| Metinho | MID | Out | Metinho is Back in training with Leg injury. | Metinho is out with leg | Feb 21 |
| Dominik Robin Schmid | MID | Doubtful | Dominik Schmid is Doubtful with Groin injury. | Schmid is doubtful with groin | Feb 21 |
| Keigo Tsunemoto | DEF | Out indefinitely | Keigo Tsunemoto is Unknown with Hip injury. | Tsunemoto is injured with hip | Jan 19 |
| Finn van Breemen | DEF | Out | Finn van Breemen is expected to return in A few weeks from Muscle injury. | van Breemen is out with muscle | Jan 29 |
| Ionut Cercel | DEF | Out indefinitely | Ionut Cercel is Unknown with Knee injury. | Cercel is injured with knee | Feb 25 |
| Mikel Gogorza | F | Out | Mikel Gogorza is expected to return Early April 2026 from Unknown. | Gogorza is out with unknown | Jan 29 |
| Edward Chilufya | MID | Out | Edward Chilufya is expected to return Late January 2026 from Knee injury. | Chilufya is out with knee | Dec 10 |
| Junior Brumado | F | Out | Júnior Brumado is expected to return Early November 2025 from Illness. | Brumado is out with illness | Oct 23 |
| Franculino | F | Out | Franculino is expected to return Early January 2026 from Unknown. | Franculino is out with unknown | Dec 11 |
| Paulinho | DEF | Out | Paulinho is expected to return Early March 2026 from Illness. | Paulinho is out with illness | Feb 22 |
| Alamara Viriato Djabi | MID | Day to day | Alamara Djabi is Day to day with Unknown. | Viriato Djabi is day-to-day with unknown | Feb 22 |
| Arlet Ze | F | Out | Junior Zé will not play due to Other. | Ze is out with unknown | Jan 29 |
| Marin Jakolis | F | Out indefinitely | Knock | Knock | Feb 28 |
| Seko Fofana | MID | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Sep 16 |
| Pablo Rosario | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Feb 11 |
| Luuk De Jong | F | Out indefinitely | Hand Injury | Hand Injury | Jun 5 |
| William Gomes | F | Suspended | William Gomes is serving a suspension for Red card. | Gomes is suspended with red card | Feb 3 |
| Francisco Moura | DEF | Suspended | Francisco Moura is serving a suspension for Yellow cards. | Moura is suspended with yellow cards | Feb 13 |
| Pepe | F | Day to day | Pepê is Day to day with Eye injury. | Pepe is day-to-day with eye | Sep 12 |
| Zaidu Sanusi | DEF | Out indefinitely | Zaidu Sanusi will not play due to National team. | Sanusi is injured with unknown | Dec 17 |
| Cyrille Bayala | F | Out | Suspended | Suspended | Apr 2 |
| Yoann Cathline | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Feb 6 |
| Emirhan Demircan | F | Doubtful | Emirhan Demircan is Doubtful with Illness. | Demircan is doubtful with illness | Jan 22 |
| Matisse Didden | MID | Doubtful | Matisse Didden is Doubtful with Unknown. | Didden is doubtful with unknown | Dec 14 |
| David Min | F | Day to day | David Min is expected to return in A few days from Unknown. | Min is day-to-day with unknown | Dec 21 |
| Niklas Vesterlund | DEF | Out | Niklas Vesterlund is expected to return in About a week from Knee injury. | Vesterlund is out with knee | Nov 13 |
| Marko Arnautovic | F | Out | Foot Injury | Foot Injury | Feb 4 |
| Milos Veljkovic | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 3 |
| Caglar Soyuncu | DEF | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Dec 6 |
| Matteo Guendouzi | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 2 |
| Nelson Semedo | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Aug 15 |
| Fred | MID | Out | Groin/Pelvis Injury | Groin/Pelvis Injury | Apr 28 |
| Edson Alvarez | MID | Out | Suspended | Suspended | Nov 10 |
| Kerem Akturkoglu | F | Out indefinitely | Hamstring | Hamstring | Apr 10 |
| Sidiki Cherif | F | Out | Sidiki Cherif is expected to return in About 1-2 weeks from Ankle injury. | Cherif is out with ankle | Jan 30 |
| Talisca | MID | Out | Talisca is expected to return Mid March 2026 from Leg injury. | Talisca is out with leg | Feb 24 |
| Jordan Lotomba | DEF | Out | Ankle/Foot Injury | Ankle/Foot Injury | Apr 11 |
| Bart Nieuwkoop | DEF | Out | Bart Nieuwkoop is expected to return Late December 2025 from Unknown. | Nieuwkoop is out with unknown | Dec 6 |
| Jeremiah St. Juste | DEF | Out | Jeremiah St. Juste will not play due to Other. | St. Juste is out with unknown | Jan 29 |
| Timon Wellenreuther | GK | Suspended | Timon Wellenreuther is serving a suspension for Yellow cards. | Wellenreuther is suspended with yellow cards | Feb 9 |
| Goncalo Borges | F | Out indefinitely | Gonçalo Borges will not play due to Personal reason. | Borges is injured with unknown | Sep 17 |
| Leo Sauer | F | Out | Leo Sauer is expected to return Late December 2025 from Unknown. | Sauer is out with unknown | Nov 30 |
| Sem Steijn | MID | Out | Sem Steijn is expected to return Late February 2026 from Unknown. | Steijn is out with unknown | Jan 29 |
| Luciano Valente | MID | Suspended | Luciano Valente is serving a suspension for Yellow cards. | Valente is suspended with yellow cards | Feb 9 |
| Tsuyoshi Watanabe | DEF | Out | Tsuyoshi Watanabe is expected to return Late February 2026 from Unknown. | Watanabe is out with unknown | Jan 29 |
| Mats Deijl | DEF | Out | Mats Deijl will not play due to Other. | Deijl is out with unknown | Jan 29 |
| Lukas Kubler | DEF | Out | Lukas Kübler is expected to return Late February 2026 from Hamstring Injury. | Kubler is out with hamstring | Jan 25 |
| Vincenzo Grifo | MID | Out indefinitely | Virus | Virus | Apr 18 |
| Philipp Lienhart | DEF | Out | Philipp Lienhart is expected to return Late February 2026 from Abdominal injury. | Lienhart is out with abdominal | Feb 12 |
| Maximilian Rosenfelder | DEF | Out | Max Rosenfelder is expected to return in A few weeks from Hamstring Injury. | Rosenfelder is out with hamstring | Feb 16 |
| Jan-Niklas Beste | MID | Suspended | Jan-Niklas Beste is serving a suspension for Yellow cards. | Beste is suspended with yellow cards | Feb 23 |
| Junya Ito | MID | Out | Suspended | Suspended | Oct 16 |
| Noah Adedeji-Sternberg | F | Doubtful | Noah Adedeji-Sternberg is Doubtful with Muscle injury. | Adedeji-Sternberg is doubtful with muscle | Feb 12 |
| Konstantinos Karetsas | MID | Out | Konstantinos Karetsas is expected to return Early October 2025 from Back injury. | Karetsas is out with back | Sep 20 |
| Tobias Lawal | GK | Out | Tobias Lawal is expected to return in About a week from Knee injury. | Lawal is out with knee | Nov 1 |
| Yira Sor | MID | Day to day | Yira Sor is Day to day with Unknown. | Sor is day-to-day with unknown | Sep 20 |
| Thibo Baeten | F | Suspended | Thibo Baeten is serving a suspension for Red card. | Baeten is suspended with red card | Feb 16 |
| Pim Saathof | MID | Out | Pim Saathof will not play due to Other. | Saathof is out with unknown | Jan 29 |
| Soren Tengstedt | F | Out | Sören Tengstedt is Back in training with Muscle injury. | Tengstedt is out with muscle | Jan 11 |
| Olivier Giroud | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 11 |
| Nabil Bentaleb | MID | Out indefinitely | Back Injury | Back Injury | Jan 2 |
| Thomas Meunier | DEF | Out indefinitely | Back Injury | Back Injury | Apr 10 |
| Chancel Mbemba | DEF | Out | Knee Injury | Knee Injury | Jan 13 |
| Alexsandro Ribeiro | DEF | Out | Alexsandro Ribeiro is expected to return Early March 2026 from Calf injury. | Ribeiro is out with calf | Feb 18 |
| Ethan Mbappe | MID | Out | Ethan Mbappe is expected to return Early April 2026 from Hamstring Injury. | Mbappe is out with hamstring | Feb 2 |
| Ousmane Toure | DEF | Out indefinitely | Toure, Ousmane: missing - injured | Toure is injured | Aug 23 |
| Osame Sahraoui | MID | Out | Osame Sahraoui is expected to return Early March 2026 from Groin injury. | Sahraoui is out with groin | Feb 21 |
| Aguibou Camara | MID | Out | Aguibou Camara is expected to return Mid April 2026 from Muscle injury. | Camara is out with muscle | Jan 19 |
| Ainsley Maitland-Niles | MID | Out indefinitely | Virus | Virus | Jan 3 |
| Corentin Tolisso | MID | Out | Calf/Shin Injury | Calf/Shin Injury | Mar 4 |
| Orel Mangala | MID | Out indefinitely | None | Mangala is injured | Feb 13 |
| Abner Vinicius | DEF | Out indefinitely | None | Vinicius is injured | Feb 17 |
| Malick Fofana | F | Out | Malick Fofana is expected to return Early March 2026 from Ankle injury. | Fofana is out with ankle | Feb 21 |
| Pavel Sulc | MID | Out | Pavel Sulc is expected to return Mid March 2026 from Thigh injury. | Sulc is out with thigh | Feb 23 |
| Raz Shlomo | DEF | Out | Raz Shlomo is expected to return in About 1-2 weeks from Foot injury. | Shlomo is out with foot | Feb 17 |
| Anders Christiansen | MID | Out | Anders Christiansen is expected to return Mid November 2025 from Thigh injury. | Christiansen is out with thigh | Nov 1 |
| Johan Dahlin | GK | Doubtful | Johan Dahlin is Doubtful with Cruciate ligament injury. | Dahlin is doubtful with knee | Oct 2 |
| Arnor Sigurdsson | MID | Out | Arnór Sigurdsson is expected to return Early January 2026 from Knee injury. | Sigurdsson is out with knee | Dec 21 |
| Jonathan Clauss | DEF | Out | Groin Strain | Groin Strain | Jan 24 |
| Youssouf Ndayishimiye | MID | Out indefinitely | Knock | Knock | Apr 3 |
| Sepe Elye Wahi | F | Out | Elye Wahi is expected to return in A few weeks from Ankle injury. | Wahi is out with ankle | Feb 16 |
| Willy Boly | DEF | Out | Hamstring | Hamstring | Apr 11 |
| Chris Wood | F | Out | Chris Wood is expected to return Mid April 2026 from Knee injury. | Wood is out with knee | Jan 28 |
| John Victor | GK | Out | John Victor is expected to return Early June 2026 from Knee injury. | Victor is out with knee | Jan 28 |
| Giulian Biancone | DEF | Out indefinitely | Knee Injury | Knee Injury | Apr 11 |
| Fabiano | GK | Out for season | Fabiano is Out for season with Back injury. | Fabiano is out for season with back | Feb 25 |
| Jonjoe Kenny | DEF | Out indefinitely | Concussion | Concussion | Feb 6 |
| Dejan Lovren | DEF | Out | Concussion | Concussion | Apr 11 |
| Rahman Baba | DEF | Out indefinitely | Knee Injury | Knee Injury | Dec 8 |
| Soualiho Meite | MID | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Dec 11 |
| Jorge Sanchez | DEF | Out indefinitely | Knock | Knock | Oct 8 |
| Kiril Despodov | F | Out indefinitely | Kiril Despodov is Unknown with Muscle injury. | Despodov is injured with muscle | Feb 13 |
| Christos Zafeiris | MID | Suspended | Christos Zafeiris is serving a suspension for Yellow cards. | Zafeiris is suspended with yellow cards | Nov 10 |
| Anestis Mythou | F | Out | Anestis Mythou is expected to return in About a week from Illness. | Mythou is out with illness | Feb 26 |
| Moussa Sissoko | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Sep 8 |
| Renato Sanches | MID | Out | Groin/Pelvis Injury | Groin/Pelvis Injury | Mar 13 |
| Pedro Chirivella | MID | Out indefinitely | Groin Strain | Groin Strain | Apr 11 |
| Erik Palmer-Brown | DEF | Out indefinitely | Knock | Knock | Dec 20 |
| Cyriel Dessers | F | Out | Cyriel Dessers is expected to return Mid September 2025 from Knee injury. | Dessers is out with knee | Aug 26 |
| Jack Butland | GK | Out indefinitely | Hand Injury | Hand Injury | Nov 7 |
| Rabbi Matondo | MID | Out | Rabbi Matondo is expected to return Early January 2026 from Knee injury. | Matondo is out with knee | Dec 21 |
| Bailey Rice | MID | Out | Bailey Rice is expected to return Early March 2026 from Muscle injury. | Rice is out with muscle | Feb 21 |
| Dujon Sterling | DEF | Out | Dujon Sterling is expected to return Mid February 2026 from Muscle injury. | Sterling is out with muscle | Feb 1 |
| Bojan Miovski | F | Out indefinitely | None | Miovski is injured | May 24 |
| Hector Bellerin | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Oct 29 |
| Adrian | GK | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Jan 3 |
| Pablo Fornals | MID | Out indefinitely | None | Fornals is injured | Jan 20 |
| Junior Firpo | DEF | Out | Knee Injury | Knee Injury | Sep 3 |
| Cucho Hernandez | F | Out | Thigh Muscle Strain | Thigh Muscle Strain | May 22 |
| Abde Ezzalzouli | F | Out | Suspended | Suspended | Feb 12 |
| Isco | MID | Out | Isco is expected to return Mid March 2026 from Thigh injury. | Isco is out with thigh | Feb 27 |
| Paulo Dybala | F | Doubtful | Paulo Dybala is Doubtful with Knee injury. | Dybala is doubtful with knee | Feb 15 |
| Angelino | DEF | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Sep 13 |
| Kostas Tsimikas | DEF | Out | Knock | Knock | Aug 15 |
| Zeki Celik | DEF | Out | Suspended | Suspended | Feb 20 |
| Matias Soule | F | Doubtful | Matias Soule is Doubtful with Muscle injury. | Soule is doubtful with muscle | Feb 25 |
| Akim Zedadka | DEF | Doubtful | None | Zedadka is doubtful | Aug 16 |
| Stefan Lainer | DEF | Out indefinitely | Knock | Knock | Nov 11 |
| Yorbe Vertessen | F | Out | Yorbe Vertessen is expected to return in About 1-2 weeks from Knock injury. | Vertessen is out with knock injury | Feb 6 |
| Anrie Chase | DEF | Out indefinitely | None | Chase is injured | Mar 7 |
| John Mellberg | DEF | Out indefinitely | John Mellberg is Unknown with Thigh injury. | Mellberg is injured with thigh | Jan 29 |
| Alexander Schlager | GK | Doubtful | Alexander Schlager is Doubtful with Hip injury. | Schlager is doubtful with hip | Nov 9 |
| Vinicius Tobias | DEF | Doubtful | None | Tobias is doubtful | Feb 9 |
| Jusuf Gazibegovic | DEF | Out | Jusuf Gazibegovic is expected to return in A few weeks from Thigh injury. | Gazibegovic is out with thigh | Feb 15 |
| Leon Grgic | F | Out | Leon Grgic is expected to return in A few weeks from Ankle injury. | Grgic is out with ankle | Dec 8 |
| Otar Kiteishvili | MID | Out | Otar Kiteishvili is expected to return in A few weeks from Hip injury. | Kiteishvili is out with hip | Feb 15 |
| Dimitri Lavalee | DEF | Out for season | Dimitri Lavalée is Out for season with Knee injury. | Lavalee is out for season with knee | Dec 3 |
| Dan Zagadou | DEF | Doubtful | Dan-Axel Zagadou is Doubtful with Tendon injury. | Zagadou is doubtful with tendon | Feb 25 |
| Julian Chabot | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Nov 3 |
| Ermedin Demirovic | F | Out | Suspended | Suspended | Apr 11 |
| Tiago Tomas | F | Out indefinitely | Knock | Knock | Feb 27 |
| Justin Diehl | F | Doubtful | Justin Diehl is Doubtful with Muscle injury. | Diehl is doubtful with muscle | Feb 25 |
| Edimilson Fernandes | DEF | Out indefinitely | Illness | Illness | Sep 19 |
| Saidy Janko | DEF | Out indefinitely | Hamstring | Hamstring | Feb 5 |
| Yan Valery | DEF | Out indefinitely | Knock | Knock | Jan 30 |
| Gregory Wuthrich | DEF | Doubtful | Gregory Wüthrich is Doubtful with Muscle injury. | Wuthrich is doubtful with muscle | Nov 9 |
| Loris Benito | DEF | Out indefinitely | Loris Benito is Unknown with Muscle injury. | Benito is injured with muscle | Nov 10 |
| Joel Monteiro | F | Out | Joel Monteiro is expected to return in A few weeks from Muscle injury. | Monteiro is out with muscle | Dec 17 |
| Olivier Mambwa | DEF | Suspended | Olivier Mambwa is serving a suspension for Red card. | Mambwa is suspended with red card | Jan 31 |
