Clemson vs. Louisville Odds & Betting Predictions - November 15, 2025

Clemson at Louisville

12:30 am • ESPN

Clemson Tigers

@

Louisville Cardinals

MatchupOpenSpreadTotalMoneyline
Clemson 3-5	-6.5	-5.5-112	o60.5-110	-220
Louisville 7-1	u60.5	+5.5-108	u60.5-110	+181

location pin

Saturday 12:30 a.m.

November 15, 2025

L&N Federal Credit Union StadiumLouisville

thermometer image

57°Fahrenheit

rain image

0%Rain

wind image

4Wind

No props found

NCAAF Public Betting

Louisville are 4-1 in their last 5 games.
Louisville are 1-4 in their last 5 games against the spread
Louisville are 3-0 in their road games against the spread
The totals have gone OVER in 2 of Louisville' last 5 games
The totals have gone OVER in 3 of Louisville' 5 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Louisville	3-5	0-5	3-0	2-5	1-0
Clemson	2-6	0-5	2-1	2-6	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Louisville	4-4	3-2	1-2	4-3	0-1
Clemson	4-4	3-2	1-2	4-4	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Louisville	7-1	N/A	N/A	6-1	1-0
Clemson	3-5	N/A	N/A	3-5	N/A

date	opponent	score	spread	over/under	moneyline
Nov 1st	@VT	W 28-16	-10.5 W	U 52.5	LOU -395
Oct 25th	BC	W 38-24	-25.5 L	O 54.5	LOU -2800
Oct 17th	@MIA	W 24-21	+10.5 W	U 49.5	LOU +340
Oct 4th	UVA	L 27-30	-6.5 L	U 60	UVA -245
Sep 27th	@PITT	W 34-27	-6.5 W	O 53.5	LOU -155

Total

Passing

2375

YDS

2016

198/299

Comps/Atts

186/285

7.94

YPA

7.07

17/6

TDs/INTs

12/7

12/75

Sacks/Yards

16/127

Rushing

990

Rush Yards

1246

248

Attempts

246

3.99

YPC

5.07

12

TDs

18

Turnovers

Fumbles Lost

6

Interceptions

7

Efficiency

22/26 84.6%

Redzone

21/24 87.5%

39/103 0%

3rd Down

43/106 0%

14/24 0%

4th Down

3/6 0%

First Downs

175

Total

165

104

Pass

90

58

Rush

61

13

Penalty

14

Misc

/

Penalties/Yards

/

Could not load odds

See more NCAAF Odds

MatchupOverUnder
Clemson 3-5	N/A	N/A
Louisville 7-1	N/A	N/A