USC vs. Notre Dame Odds & Betting Predictions - October 18, 2025

USC at Notre Dame

11:30 pm • NBC

USC Trojans

@

Notre Dame Fighting Irish

MatchupOpenSpreadTotalMoneyline
USC 4-1	+10.5	+10.5-110	o53.5-110	+277
Notre Dame 3-2	u53.5	-10.5-110	u53.5-110	-352

location pin

Saturday 11:30 p.m.

October 18, 2025

Notre Dame StadiumSouth Bend

No props found

NCAAF Public Betting

Notre Dame are 3-2 in their last 5 games.
Notre Dame are 2-3 in their last 5 games against the spread
Notre Dame are 1-1 in their road games against the spread
The totals have gone OVER in 4 of Notre Dame' last 5 games
The totals have gone OVER in 2 of Notre Dame' 3 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Notre Dame	2-3	1-2	1-1	2-3	N/A
USC	2-3	2-1	0-2	2-3	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Notre Dame	4-1	2-1	2-0	4-1	N/A
USC	4-1	3-0	1-1	4-1	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Notre Dame	3-2	N/A	N/A	3-2	N/A
USC	4-1	N/A	N/A	4-1	N/A

date	opponent	score	spread	over/under	moneyline
Oct 4th	BOISE	W 28-7	-21.5 L	U 63	ND -1600
Sep 27th	@ARK	W 56-13	-5.5 W	O 63.5	ND -218
Sep 20th	PUR	W 56-30	-24.5 W	O 51	ND -4000
Sep 13th	TA&M	L 40-41	-6.5 L	O 49.5	TA&M -250
Aug 31st	@MIA	L 24-27	-3 L	O 50.5	MIA -148

Total

Passing

1690

YDS

1415

111/154

Comps/Atts

95/137

10.97

YPA

10.33

12/1

TDs/INTs

11/2

4/28

Sacks/Yards

7/59

Rushing

1135

Rush Yards

893

177

Attempts

181

6.41

YPC

4.93

17

TDs

15

Turnovers

Fumbles Lost

1

Interceptions

2

Efficiency

28/29 96.6%

Redzone

19/21 90.5%

31/55 0%

3rd Down

27/53 0%

9/11 0%

4th Down

4/11 0%

First Downs

133

Total

119

72

Pass

63

49

Rush

46

12

Penalty

10

Misc

/

Penalties/Yards

/

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MatchupOverUnder
USC 4-1	N/A	N/A
Notre Dame 3-2	N/A	N/A