The Kansas City Royals host the Houston Astros on Friday, April 25. First pitch from Kauffman Stadium is scheduled for 7:40 p.m. EDT; the game will be broadcast on MLB.TV.
Find my Astros vs Royals prediction below, as well as probable pitchers, betting trends and more.
My Astros vs Royals Prediction
- Astros vs Royals picks: Seth Lugo Over 4.5 Strikeouts (+120)
My Astros vs Royals best bet is on Seth Lugo. Make sure to find the best odds by checking our live MLB odds page.
Astros vs Royals Odds
April 25, 2025
7:40 p.m. EDT
SCHN
| Astros Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +146 | 8 -105o / -115u | -118 |
| Royals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -176 | 8 -105o / -115u | +100 |
Odds via FanDuel. Get up-to-the-minute MLB odds here.
Astros vs Royals Prediction, Betting Analysis
For Friday night's matchup between the Houston Astros and the Kansas City Royals, our top betting recommendation revolves around Royals pitcher Seth Lugo and his strikeout potential.
