NFL Odds Thursday Night Football: The Colts vs. Broncos Bet That Sharps Are Making in Week 5

NFL Odds Thursday Night Football: The Colts vs. Broncos Bet That Sharps Are Making in Week 5 article feature image
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Photo by Michael Hickey/Getty Images. Pictured: Matt Ryan #2 of the Indianapolis Colts

  • NFL odds for Thursday Night Football have been on the move thanks to sharps betting Colts vs. Broncos.
  • In addition, Jonathan Taylor's injury has also had an effect on Colts vs. Broncos odds for Thursday Night Football.
  • Below we break down the latest NFL odds movement for Colts vs. Broncos, including how wiseguys are betting tonight's game.

NFL Odds: Colts vs. Broncos

Colts Odds+3.5
Broncos Odds-3.5
Over/Under42
DateThursday, Oct. 6
Time8:15 p.m. ET
ChannelAmazon Prime Video

*NFL odds as of Thursday morning

Both the Indianapolis Colts and Denver Broncos landed new starting quarterbacks over the offseason, and on Thursday Night both will be relying on their signal-callers to prevent their teams from heading into Week 6 with losing records.

NFL odds for Thursday Night Football have the Broncos as 3- to 3.5-point favorites over the Colts depending on the sportsbook, with the over/under sitting at 42.

In addition, news broke on Wednesday that Indianapolis will be without its best player, Jonathan Taylor, due to an ankle injury, which will clearly make it harder for the Colts on the offensive side of the ball.

With this in mind, what is the smartest way to bet Colts vs. Broncos on Thursday Night Football?

According to the market's sharpest NFL bettors, the answer is an easy one.

NFL Pick: Colts vs. Broncos

In the case of Colts vs. Broncos, the sharp play is the obvious play.