The Detroit Tigers (2-4) host the St. Louis Cardinals (4-2) on April 3, 2026. First pitch from Comerica Park is scheduled for 1:10 p.m. EDT. The game will be broadcast on CARD.
The Tigers are favored by -174 on the moneyline and by -1.5 (+116) on the run line. The Cardinals are +146 on the moneyline and +1.5 (-140) on the run line. The total is set at 8 runs (-110 / -110).
Find my MLB picks and Cardinals vs Tigers prediction below, as well as probable pitchers, weather report, and more.
Cardinals vs Tigers Predictions, Pick
- Cardinals vs Tigers Pick: Cardinals ML (+150 or Better)
My Cardinals vs Tigers best bet is on the Cardinals to win. Make sure to find the best odds by checking our live MLB odds page.
Cardinals vs Tigers Odds, Spread, Line
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -140 | 8 -110o / -110u | +146 |
| Tigers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +116 | 8 -110o / -110u | -174 |
- Cardinals vs Tigers spread: Tigers -1.5 (+116), Cardinals +1.5 (-140)
- Cardinals vs Tigers over/under: 8 (-110 / -110)
- Cardinals vs Tigers moneyline: Cardinals +146, Tigers -174
Cardinals vs Tigers Probable Pitchers
| Michael McGreevy (RHP) | Stat | Framber Valdez (LHP) |
|---|---|---|
| 0-0 | W-L | 0-0 |
| 0.2 | fWAR (FanGraphs) | 0.2 |
| 0.00 / 5.18 | ERA / xERA | 1.50 / 3.12 |
| 2.50 / 4.69 | FIP / xFIP | 2.00 / 3.46 |
| 0.33 | WHIP | 1.33 |
| 14.3% | K-BB% | 16% |
| 28.6% | GB% | 47.4% |
| 78 | Stuff+ | 116 |
| 106 | Location+ | 113 |
Cardinals vs Tigers Expert MLB Pick
This game triggered one of our Action PRO betting systems, powered by Evan Abrams.
In Major League Baseball, road underdogs playing interleague games have historically been undervalued by oddsmakers.
Since 2016, despite winning only 43.3% of these games, these teams have generated a consistent positive ROI of 4.6%.
This trend has proven reliable across five consecutive seasons, indicating market inefficiencies in how these specific matchups are priced — likely due to lack of familiarity between leagues and public overconfidence in home and favorite teams.
Pick: Cardinals ML (+150 or Better)
