The Boston Red Sox host the San Diego Padres on April 3, 2026. First pitch from Fenway Park is scheduled for 2:10 p.m. ET. The game will be broadcast on NESN and MLB.TV.
The Red Sox are favored by -124 on the moneyline and by +1.5 (-205) on the run line. The Padres are +106 on the moneyline and -1.5 (+168) on the run line. The total is set at 8.5 runs (-100 / -122).
Find my MLB picks and Padres vs Red Sox prediction below, as well as probable pitchers, weather report, and more.
San Diego Padres vs Boston Red Sox Predictions and Pick
- Padres vs Red Sox Pick: Padres ML (+100 or Better)
My Padres vs Red Sox best bet is on San Diego to win this road game. Make sure to find the best odds by checking our live MLB odds page.
Padres vs Red Sox Odds, Run Line, and Over/Under
| Padres Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +168 | 8.5 100o / -122u | +106 |
| Red Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -205 | 8.5 100o / -122u | -124 |
- Padres vs Red Sox Run Line: Padres -1.5 (+168), Red Sox +1.5 (-205)
- Padres vs Red Sox Over/Under: 8.5
- Padres vs Red Sox Moneyline: Padres ML +106, Red Sox ML -124
Padres vs Red Sox Probable Pitchers
| Michael King (RHP) | Stat | Sonny Gray (RHP) |
|---|---|---|
| 0-0 | W-L | 0-0 |
| 0.1 | fWAR (FanGraphs) | 0.0 |
| 0.00 / 4.00 | ERA / xERA | 6.75 / 9.24 |
| 3.77 / 4.93 | FIP / xFIP | 4.67 / 2.51 |
| 1.00 | WHIP | 1.75 |
| 10% | K-BB% | 20% |
| 44.4% | GB% | 71.4% |
| 95 | Stuff+ | 104 |
| 78 | Location+ | 99 |
Padres vs Red Sox MLB Betting Preview
This game triggered one of our Action PRO betting systems, powered by Evan Abrams.
In Major League Baseball, road underdogs playing interleague games have historically been undervalued by oddsmakers.
Since 2016, despite winning only 43.3% of these games, these teams have generated a consistent positive ROI of 4.6%.
This trend has proven reliable across five consecutive seasons, indicating market inefficiencies in how these specific matchups are priced — likely due to lack of familiarity between leagues and public overconfidence in home and favorite teams.
Padres vs Red Sox Pick, Betting Analysis
The Red Sox are a mess right now. They're 1-5 with a -15 run differential, the second-worst in baseball, leading only the lowly White Sox (-31).
Part of their problem was the inability to sign top-end talent in the offseason. Installing Sonny Gray as their No. 2 starter is the perfect example. He's an OK righty, but not exactly a top-tier starter, and he got rocked by the Reds in his Boston debut.
Michael King is an interesting sinkerballer who avoids hard contact well. He had an OK 2026 debut, but he upped his velocity a tick, so we're willing to buy in and fade the slopfest in Boston.
Pick: Padres ML (+100 or Better)
