The Chicago Cubs host the Philadelphia Phillies on April 22, 2026. First pitch from Wrigley Field is scheduled for 7:40 p.m. EDT. The game will be broadcast on NBCS-PH+.
The Cubs are favored by -174 on the moneyline and by -1.5 on the run line. The Phillies are +146 on the moneyline and +1.5 on the run line. The total is set at 8 runs.
Find my MLB picks and Phillies vs Cubs prediction below, as well as probable pitchers, weather report, and more.
Phillies vs Cubs Predictions and Picks
- Phillies vs Cubs Pick: Matthew Boyd Over 5.5 Strikeouts (+110 or Better)
Phillies vs Cubs Odds, Run Line and Total
Wednesday, Apr 22
7:40 p.m. ET
NBCS-PH+
| Phillies Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -152 | 8 -110o / -110u | +146 |
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +126 | 8 -110o / -110u | -174 |
Odds via FanDuel. Get up-to-the-minute MLB odds here.
- Phillies vs Cubs moneyline: Phillies +146, Cubs -174
- Phillies vs Cubs over/under: 8 (-110o / -110u)
- Phillies vs Cubs spread: Cubs -1.5 (+126), Phillies +1.5 (-152)
Phillies vs Cubs Probable Pitchers
| Kyle Backhus (LHP, PHI) | Stat | Matthew Boyd (LHP, CHC) |
|---|---|---|
| 0-0 | W-L | 1-1 |
| 0.0 | fWAR (FanGraphs) | 0.3 |
| 5.40 / 3.52 | ERA / xERA | 6.75 / 4.42 |
| 4.79 / 2.13 | FIP / xFIP | 1.86 / 1.79 |
| 28.6% | K-BB% | 37.8% |
| 44.4% | GB% | 23.5% |
| .313 | BABIP | .438 |
| 109 | Stuff+ | 95 |
| 101 | Location+ | 119 |
Phillies vs Cubs MLB Picks and Prop Bets
Our Action PRO Prop projections show value on Matthew Boyd's strikeout prop.
Boyd's implied strikeout total is sitting between 4.9 and 5.2, but we're projecting him for nearly six Ks on Wednesday.
That represents nearly a 10% edge over the market!
Pick: Matthew Boyd Over 5.5 Strikeouts (+110 or Better)
