The Cleveland Guardians (22-21) host the Los Angeles Angels (16-26) on May 12, 2026. First pitch from Progressive Field is scheduled for 6:10 p.m. EDT. The game will be broadcast on ABTV.
The Guardians are favored by -136 on the moneyline and by -1.5 (+150) on the run line. The Angels are +116 on the moneyline and +1.5 (-182) on the run line. The total is set at 8.5 runs.
Find my MLB picks and Angels vs Guardians prediction below, as well as probable pitchers, weather report, and more.
Angels vs Guardians Predictions, Pick
- Angels vs Guardians Pick: Guardians ML (-150 or Better)
My Angels vs Guardians best bet is on Cleveland to win. Make sure to find the best odds by checking our live MLB odds page.
Angels vs Guardians Odds, Spread, Line
| Angels Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -182 | 8.5 -108o / -112u | +116 |
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +150 | 8.5 -108o / -112u | -136 |
- Angels vs Guardians moneyline: Angels +116, Guardians -136
- Angels vs Guardians over/under: 8.5 (-108o / -112u)
- Angels vs Guardians spread: Guardians -1.5 (+150), Angels +1.5 (-182)
Angels vs Guardians Pitchers
| Walbert Ureña (RHP, LAA) | Stat | Slade Cecconi (RHP, CLE) |
|---|---|---|
| 1-3 | W-L | 2-4 |
| 0.3 | fWAR (FanGraphs) | -0.1 |
| 3.22 / 3.28 | ERA / xERA | 6.15 / 5.61 |
| 3.88 / 4.80 | FIP / xFIP | 5.53 / 4.74 |
| 5.9% | K-BB% | 8.0% |
| 51.6% | GB% | 43.7% |
| .290 | BABIP | .318 |
| 101 | Stuff+ | 92 |
| 101 | Location+ | 100 |
Angels vs Guardians Expert MLB Pick
How To Bet My Angels vs Guardians Pick, Best Bet
This game triggered one of our Action PRO Betting Systems, powered by Evan Abrams:
In the early part of the season, teams often develop mini streaks — especially those on extended road or home stands.
When a team with this kind of momentum faces an opponent coming off a solid loss (but not a blowout), the rhythm-driven team can be undervalued.
And when the line modestly shifts in their favor, this indicates sharp support.
Teams in streaks are more "in rhythm" than those shifting locations or rebounding from losses, especially when early-season variance hasn’t fully settled into the betting market.
The Angels lost game one of this series on Monday, 7-2.
Meanwhile, the Guardians are 22-21 — including 11-9 at home — and in first place in the AL Central.
Pick: Guardians ML (-150 or Better)
