The Chicago White Sox (22-22) host the Chicago Cubs (29-16) on May 16, 2026. First pitch from Rate Field is scheduled for 7:10 p.m. ET. The game will be broadcast on MARQ.
The Cubs are -106 on the moneyline and by -1.5 on the run line. The White Sox are -110 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.
Find our MLB picks and Cubs vs White Sox prediction below, as well as probable pitchers, weather report, and more.
Cubs vs White Sox Prediction, Picks
- Cubs vs White Sox Pick: Chase Meidroth Over 0.5 Singles (-101)
Our Cubs vs White Sox best bet is on Chase Meidroth to hit one or more singles tonight. Make sure to find the best odds by checking our live MLB odds page.
Cubs vs White Sox Odds, Spread, Line
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +155 | 8.5 -118o / -104u | -106 |
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -188 | 8.5 -118o / -104u | -110 |
- Cubs vs White Sox moneyline: Cubs -106, White Sox -110
- Cubs vs White Sox over/under: 8.5 (-118o / -104u)
- Cubs vs White Sox spread: Cubs -1.5 (+155), White Sox +1.5 (-188)
Cubs vs White Sox Probable Pitchers
| RHP Jameson Taillon (CHC) | Stat | RHP Davis Martin (CHW) |
|---|---|---|
| 2-2 | W-L | 5-1 |
| -0.2 | fWAR (FanGraphs) | 1.9 |
| 3.94 / 4.21 | ERA / xERA | 1.62 / 3.89 |
| 5.66 / 4.50 | FIP / xFIP | 2.32 / 3.03 |
| 12.9 | K-BB% | 21.9 |
| 34.6 | GB% | 40.8 |
| .214 | BABIP | .304 |
| 94 | Stuff+ | 89 |
| 100 | Location+ | 103 |
Cubs vs White Sox Player Prop Pick for Tonight's MLB Game
Action PRO projects White Sox 2B Chase Meidroth for 0.89 singles in tonight's matchup against the Cubs, giving us a solid 8.7% edge against the market when compared to his current prop line of over/under 0.5, which is good enough to mark the over with a B- grade in our system.
Meidroth is enjoying this month so far, with a .326 average in May.
He's had hits in 12 out of his last 14 games, with 10 singles of a total of 15 hits, and will face Jameson Taillon tonight, who is not precisely an ace to fear.
How To Make Cubs vs White Sox Picks, Best Bets
In the middle of his torrid display this month, Meidroth has had singles in five of his past 10 contests.
At a great price, let's back him tonight on this prop against the Cubs.
Pick: Chase Meidroth Over 0.5 Singles (-101, DraftKings)
