Astros vs. Guardians Odds & Betting Predictions - April 22, 2026

Astros at Guardians

5:10 pm • SCHN

Houston Astros

10-16

2 - 0

Cleveland Guardians

14-12

pitcher		team	era	w-l
T.Bibee			4.45	0-3
P.Lambert			3.27	1-1

MatchupOpenSpreadTotalMoneyline
Astros 10-16	+1.5	+1.5-155	o8-113	+136
Guardians 14-12	u8	-1.5+129	u8-102	-162

Wednesday 5:10 p.m.

April 22, 2026

Progressive FieldCleveland

CLE -1-110

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HOU +135

2.03u

P.Lambert u4.5 Hits Allowed-114

0.5u

Proj closer to -140

Y.Alvarez o1.5 Total Bases+106

$1.06

Y.Alvarez o0.5 HR+370

0.93u

P.Lambert u2.5 BB-193

1.93u

HOU +120

1.2u

Under 4.5 (F5)-130

P.Lambert o3.5 Ks-168

CLE -135

0.68u

Moneyline Pick for Astros-Guardians
Doug Ziefel•
Apr 22, 2026 UTC

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MLB Public Betting

Guardians are 3-2 in their last 5 games.
Guardians are 3-2 in their last 5 games against the spread
Guardians are 6-7 in their road games against the spread
The totals have gone OVER in 3 of Guardians' last 5 games
The totals have gone OVER in 6 of Guardians' 13 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	15-11	9-4	6-7	7-5	8-6
Astros	10-16	6-7	4-9	4-11	6-4

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	13-13	6-7	7-6	6-6	7-7
Astros	17-8-1	9-4	8-4-1	9-6	7-2-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	14-12	8-5	6-7	7-5	7-7
Astros	10-16	7-6	3-10	5-10	5-5

date	opponent	score	spread	over/under	moneyline
Apr 21st	HOU	W 8-5	-1.5 W	O 8.5	CLE -101
Apr 20th	HOU	L 2-9	-1.5 L	O 7.5	HOU -135
Apr 19th	BAL	W 8-4	+1.5 W	O 6.5	CLE -120
Apr 18th	BAL	W 4-2	-1.5 W	U 7.5	CLE -146
Apr 17th	BAL	L 4-6	-1.5 L	O 8	BAL -141

Zach Dezenzo
LF
Dezenzo is out with elbow
Out

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PITCHER	PC	IP	K
RP.Lambert, P	96	6	8
RA.Blubaugh, P	17	1	1
LS.Okert, P	16	0.2	0
RE.De Los Santos, P	24	1.1	1

HITTERS	H-AB	R	HR	RBI
1C.Correa, SS	1-4	1	0	0
2Y.Alvarez, DH	3-4	1	1	2
3J.Altuve, 2B	0-4	0	0	0
4C.Walker, 1B	1-3	0	0	0
5I.Paredes, 3B	1-4	0	0	0
6C.Smith, RF	0-4	0	0	0
7D.Johnson, CF	0-4	0	0	0
8C.Vazquez, C	0-3	0	0	0
9B.Matthews, LF	0-2	0	0	0

PITCHER	PC	IP	K	ER
RT.Bibee, P	95	6	3	2
RM.Festa, P	18	1	2	0
RH.Gaddis, P	5	1	0	0
LE.Sabrowski, P	17	1	1	0

HITTERS	H-AB	R	HR	RBI
1S.Kwan, CF	1-3	0	0	0
2C.DeLauter, RF	2-4	0	0	0
3J.Ramirez, DH	1-4	0	0	0
4K.Manzardo, 1B	0-2	0	0	0
4R.Hoskins, PH	0-1	0	0	0
4R.Hoskins, 1B	0-1	0	0	0
5G.Valera, LF	0-4	0	0	0
6D.Schneemann, 3B	1-3	0	0	0
7J.Brito, 2B	0-3	0	0	0
7A.Martinez, PH	0-1	0	0	0
8B.Naylor, C	0-3	0	0	0
9B.Rocchio, SS	0-4	0	0	0