Astros vs. Cubs Odds & Betting Predictions - May 23, 2026

Astros at Cubs

6:20 pm • MARQ
@
Starting Pitchers
pitcherteameraw-l
Colin Rea logoC.ReaChicago Cubs logo4.984-2
Kai-Wei Teng logoK.TengHouston Astros logo2.612-3

Astros at Cubs Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Astros
21-31
+1.5
+1.5-170
o7.5-103
+125
Cubs
29-22
u7.5
-1.5+143
u7.5-117
-153
location pinSaturday 6:20 p.m.
May 23, 2026
Wrigley FieldChicago
thermometer image61°Fahrenheit
rain image0%Rain
wind image6Wind
Astros vs. Cubs Expert Picks
Brian Bitler
Brian Bitler
Last 30d: 88-84-0 (+41.6u)
HOU +138
3u
Doug Ziefel
Doug Ziefel
Last 30d: 186-137-2 (+22.1u)
C.Rea u17.5 Outs-105
0.53u
Under 7.5-115
0.58u
Sean Zerillo
Sean Zerillo
Last 30d: 172-147-12 (+3.2u)
Under 7.5-115
0.58u
Bet to 7 (-110)
Adam Kaufman
Adam Kaufman
Last 30d: 34-41-0 (-12.0u)
HOU +130
1u
Nick Martin
Nick Martin
Last 30d: 32-52-0 (-6.2u)
CHC -140
1u

Astros vs. Cubs Previews & Analysis

  • The Leadoff: Trollo's MLB Breakdown and Bets for Saturday article feature image

    The Leadoff: Trollo's MLB Breakdown and Bets for Saturday

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    May 23, 2026 UTC
  • Minion's +351 SGP for Astros vs Cubs article feature image

    Minion's +351 SGP for Astros vs Cubs

    Ryan Minion
    May 23, 2026 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Astros vs. Cubs Public Betting Percentages

Away Logo

Astros

Public

38%

Bets%

62%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cubs
21-3012-159-1514-197-11
Astros
21-3111-1510-164-1117-19

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cubs
28-2314-1314-1017-1611-7
Astros
27-21-416-9-111-12-39-617-15-4

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cubs
29-2218-911-1321-128-10
Astros
21-3112-149-175-1016-20

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
May 22ndHOUL 2-4-1.5 LU 7HOU -149
May 20thMILL 0-5+1.5 LU 6.5MIL -112
May 19thMILL 2-5+1.5 LU 7.5MIL +103
May 18thMILL 3-9-1.5 LO 10.5MIL -161
May 17th@CWSL 8-9-1.5 LO 9CWS -131

Astros vs. Cubs Injury Updates

Astros Injuries

  • Lance McCullers
    SP

    Lance McCullers Jr. has been scratched Tuesday. Jason Alexander will start.

    Out

Cubs Injuries

  • Tyler Austin
    1B

    Austin is out with knee

    Out

  • Justin Steele
    SP

    Steele is out with elbow

    Out

  • Jordan Wicks
    SP

    Wicks is out with arm

    Out

Astros vs. Cubs Starting Lineups
Astros Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Kai-Wei Teng logoRK.Teng, P2-32.611.0978.71
HITTERSAVGOBPSLGHR
Jeremy Pena logo1J.Pena, SS.254.297.3220
Isaac Paredes logo2I.Paredes, 3B.244.335.3755
Yordan Alvarez logo3Y.Alvarez, DH.303.416.60115
Christian Walker logo4C.Walker, 1B.254.327.48111
Jake Meyers logo5J.Meyers, CF.229.296.3331
Braden Shewmake logo6B.Shewmake, 2B.286.298.4823
Cam Smith logo7C.Smith, RF.207.298.3174
Zach Cole logo8Z.Cole, LF.170.188.3833
Cesar Salazar logo9C.Salazar, C.091.231.0910
Cubs Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Colin Rea logoRC.Rea, P4-24.981.4257.66
HITTERSAVGOBPSLGHR
Nico Hoerner logo1N.Hoerner, 2B.259.345.3834
Michael Busch logo2M.Busch, 1B.229.361.3694
Alex Bregman logo3A.Bregman, 3B.250.338.3504
Ian Happ logo4I.Happ, LF.214.350.42910
Seiya Suzuki logo5S.Suzuki, RF.261.360.4427
Moises Ballesteros logo6M.Ballesteros, DH.241.298.4466
Dansby Swanson logo7D.Swanson, SS.187.289.3497
Pete Crow-Armstrong logo8P.Crow-Armstrong, CF.228.311.3756
Miguel Amaya logo9M.Amaya, C.247.360.3973

Astros vs. Cubs Odds Comparison

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Astros at Cubs Team Totals

MatchupOverUnder
Astros
21-31
N/A
N/A
Cubs
29-22
N/A
N/A