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MLB Best Bets, Picks, Props, Predictions for Monday, September 15

MLB Best Bets, Picks, Props, Predictions for Monday, September 15 article feature image
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Today is Roberto Clemente Day in honor of the legacy of the Hall of Famer, his humanitarian efforts, and his impact on baseball. There are nine games in the MLB slate for Monday, September 15, with several of them having significant implications for the postseason.

Our betting experts and systems have found great value picks in four of them, so continue reading for today's MLB best bets.


MLB Best Bets Today

The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.

GameTime (ET)Pick
Chicago Cubs LogoPittsburgh Pirates Logo
6:40 a.m.
Atlanta Braves LogoWashington Nationals Logo
6:45 p.m.
Texas Rangers LogoHouston Astros Logo
8:10 p.m.
San Francisco Giants LogoArizona Diamondbacks Logo
9:40 p.m.
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.

Sean Paul's Cubs vs Pirates Best Bet: Back the Better Offense

Chicago Cubs Logo
Monday, September 15
6:40 a.m. ET
MLB.TV
Pittsburgh Pirates Logo
Cubs ML -135
bet365 Logo

By Sean Paul

I'm on the Cubs here to -150. I think that's a pretty strong value as a small road favorite. The Cubs own a 7-3 record over their divisional foe from Pittsburgh, and I don't see them dropping a fourth game here.

The pitching matchup is a huge boost in the Cubs' direction, given Braxton Ashcraft's likely limited workload for Pittsburgh.

The offense is the real difference here, though. The Pirates' offense is a total nightmare, and the Cubs have an offensive peak that Pittsburgh simply can't match.

Pick: Cubs ML -135 (play to -150)


Cubs vs Pirates Prediction, Pick, Odds for Monday, September 15 Image

Bet Labs' Braves vs Nationals Best Bet: System Recommends the Under

Atlanta Braves Logo
Monday, September 15
6:45 p.m. ET
MLB.TV
Washington Nationals Logo
Under 9 (-110)
bet365 Logo

By Bet Labs

The "Public Fades Humidity = Unders" system capitalizes on an overlooked weather edge in MLB totals betting.

It focuses on regular-season games where elevated humidity — ranging from 45 to 95 — intersects with moderate temperatures and neutral wind patterns, which are the conditions for this Braves vs. Nationals game today.

Despite assumptions that humidity boosts offense, public bettors are fading these conditions, which actually correlate with suppressed scoring in certain environments.

In these spots, the home team has stayed under in recent games, with their five-game over rate sitting below 40, suggesting low offensive rhythm.

The market has also subtly corrected, with the total dropping from open to close, and the overall percentage of bets on the over remains modest, between 6 and 29.

These indicators combine to identify under-the-radar under spots where public narratives misalign with actual scoring trends.

MLB Icon
Evan Abrams / Bet Labs – Public Fades Humidity = Unders
the average humidity is between 45% and 95%
the home team's 5 Game over percentage is between 0% and 40%
the temperature is between 54 and 97 degrees
the wind direction is From Right or Left To Right or From Left or Right To Left or In or None
the o/u change from open to close is between -1 and 0
the over/under % is between 6% and 29%
the game was played during the 2025 or 2024 or 2023 or 2022 or 2021 or 2020 season
betting on the Under
the game is played during the Regular season
$8,089
WON
330-226-20
RECORD
59%
WIN%

Pick: Under 9 (-110)