The Los Angeles Chargers (2-1) and San Francisco 49ers (1-1) will face off in NFL Preseason Week 3. Kickoff is set for 8:30 p.m. ET from Levi's Stadium in Santa Clara, Calif. The game will broadcast live on NFL+.
The Chargers are 1-point favorites on the spread with the game total set at 35.5 (-115o / -105u). Los Angeles is a -120 moneyline favorite to win outright; San Francisco is a +100 underdog to pull off the upset.
Let's get into my Chargers vs 49ers prediction and moneyline pick for Saturday night.
Chargers vs 49ers Odds, Lines
| Chargers Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
-1 -110 | 35.5 -115o / -105u | -120 |
| 49ers Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
+1 -110 | 35.5 -115o / -105u | +100 |
- Chargers vs 49ers Moneyline: Chargers -120, 49ers +100
- Chargers vs 49ers Total: 35.5 (-115o / -105u)
- Chargers vs 49ers Spread: Chargers -1 (-110), 49ers +1 (-110)
My Chargers vs 49ers best bet is on the Chargers' first-half moneyline. Make sure to find the best odds by checking our live NFL odds page.
Chargers vs 49ers Preview, Prediction
The 49ers will host the Chargers on Saturday Night as both teams wrap up the preseason.
Los Angeles will attempt to finish with a win and improve their record to 3-1.
I love this spot for the Chargers tonight in the first half.
Jim Harbaugh's team has the edge at the quarterback position tonight. Former 49er Trey Lance will be under center in the first half.
Lance has impressed in the preseason and will continue his success against his former team tonight.
Pick: Chargers 1H ML (-142, DraftKings)
Spread
I'm not interested in the spread for this game.
Moneyline
As mentioned, I prefer to go with the first-half moneyline, backing the Chargers early.
Over/Under
I have no play on the total.
Chargers vs 49ers Betting Trends
Chargers vs 49ers Viewing Info: Channel, Start Time, Streaming
| Location: | Levi's Stadium in Santa Clara, Calif. |
| Date: | Saturday, August 23 |
| Time: | 8:30 p.m. ET |
| TV / Streaming Options: | NFL+; ESPN Unlimited |
