Rams vs. 49ers Odds & Betting Predictions - November 9, 2025

Rams at 49ers

9:25 pm • FOX

Los Angeles Rams

San Francisco 49ers

MatchupOpenSpreadTotalMoneyline
Rams 6-2	+1.5	-3.5-110	o49.5-110	-185
49ers 6-3	u46.5	+3.5-111	u49.5-110	+155

Sunday 9:25 p.m.

November 09, 2025

Levi's StadiumSanta Clara

70°Fahrenheit

0%Rain

2Wind

LA -3-105

@wheatonbrando Week 10 Hot Read https://myaction.app/pW5ZLhuMZXb

LA -3-110

1.5u

🔥 Week 10 Hot Read 🔥

LA -3+108

0.9u

4% ev play to +100

Anderson's Early NFL Week 10 Picks
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Nov 3, 2025 UTC
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NFL Public Betting

49ers are 2-3 in their last 5 games.
49ers are 2-3 in their last 5 games against the spread
49ers are 4-2 in their road games against the spread
The totals have gone OVER in 3 of 49ers' last 5 games
The totals have gone OVER in 1 of 49ers' 3 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
49ers	5-4	1-2	4-2	3-2	2-2
Rams	6-2	3-1	2-1	6-1	0-1

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
49ers	5-4	1-2	4-2	3-2	2-2
Rams	3-5	1-3	2-1	2-5	1-0

Straight-Up (ML) History

	overall	home	away	favorite	underdog
49ers	6-3	N/A	N/A	4-1	2-2
Rams	6-2	N/A	N/A	6-1	0-1

date	opponent	score	spread	over/under	moneyline
Nov 2nd	@NYG	W 34-24	-2.5 W	O 47.5	SF -146
Oct 26th	@HOU	L 15-26	+3 L	U 41.5	HOU +130
Oct 20th	ATL	W 20-10	-0.5 W	U 46.5	SF -105
Oct 12th	@TB	L 19-30	+3.5 L	O 47	TB +160
Oct 3rd	@LA	W 26-23	+7.5 W	O 43.5	SF +340

Tutu Atwell
WR
Atwell is out with hamstring
Out

Brandon Aiyuk
WR
Aiyuk is out with knee
Out
Brock Purdy
QB
Purdy is out with toe
Out
Ricky Pearsall
WR
Pearsall is out with knee
Out
Jacob Cowing
WR
Cowing is out with hamstring
Out

Jordan James
RB
James is doubtful with finger
Doubtful

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passing yards
Mac Jones
1832
pyds
passing touchdowns
Mac Jones
10
ptd
rushing yards
Christian McCaffrey
596
ryds
rushing touchdowns
Christian McCaffrey
4
rtd

	Starter	2ND	3RD	4TH
QB	Brock Purdy	Mac Jones	Kurtis Rourke
RB	Christian McCaffrey	Isaac Guerendo	Jordan James
WR	Jauan Jennings	Jacob Cowing	Skyy Moore	Junior Bergen
TE	George Kittle	Luke Farrell	Jake Tonges	Brayden Willis
LT	Trent Williams	Spencer Burford
LG	Ben Bartch	Nick Zakelj
C	Jake Brendel	Matt Hennessy	Drake Nugent
RG	Dominick Puni	Connor Colby
RT	Colton McKivitz	Austen Pleasants
LDE	Nick Bosa	Yetur Gross-Matos	Robert Beal	William Bradley-King
RDE	Mykel Williams	Bryce Huff	Sam Okuayinonu
WLB	Dee Winters	Nick Martin	Stone Blanton	Jalen Graham
MLB	Fred Warner	Luke Gifford	Tatum Bethune	Curtis Robinson
LCB	Renardo Green	Jakob Robinson
SS	Ji'Ayir Brown	Malik Mustapha	Derrick Canteen
FS	Jason Pinnock	Marques Sigle	Siran Neal
RCB	Deommodore Lenoir	Darrell Luter
P	Thomas Morstead
PR	Jacob Cowing	Junior Bergen	Jordan Watkins	Ricky Pearsall
KR	Isaac Guerendo	Junior Bergen
LS	Jon Weeks
NT	Jordan Elliott	C.J. West	Kalia Davis
NB	Upton Stout	Chase Lucas
RWR	Ricky Pearsall	Jordan Watkins	Malik Turner
FB	Kyle Juszczyk
DT	Kevin Givens	Alfred Collins	Sebastian Valdez	Evan Anderson
LWR	Brandon Aiyuk	Russell Gage	Malik Turner

Total

Passing

2064

YDS

2295

184/275

Comps/Atts

216/323

7.807

YPA

7.486

21/2

TDs/INTs

14/9

13/83

Sacks/Yards

18/123

Rams

Rushing

49ers

895

Rush Yards

874

218

Attempts

249

4.106

YPC

3.51

TDs

Rams

Turnovers

49ers

Fumbles Lost

Interceptions

Rams

Efficiency

49ers

21/35 60%

Redzone

17/30 56.67%

36/91 0%

3rd Down

57/121 0%

10/14 0%

4th Down

7/12 0%

Rams

First Downs

49ers

184

Total

192

106

Pass

123

Rush

Penalty

Rams

Misc

49ers

Penalties/Yards

Possession

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MatchupOverUnder
Rams 6-2	N/A	N/A
49ers 6-3	N/A	N/A

Rams vs. 49ers Odds & Betting Predictions - November 9, 2025

Rams at 49ers

Los Angeles Rams

San Francisco 49ers

Rams at 49ers Odds

Spread, Total, Moneyline

Rams vs. 49ers Previews & Analysis

Anderson's Early NFL Week 10 Picks

The NFL Week 10 Bets We've Already Made! | The Hot Read

Rams vs. 49ers Props

Prop Projections

Prop Odds Comparison

Line Movement Tracker

Rams vs. 49ers Public Betting Percentages

Rams

Public

49ers

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Rams vs. 49ers Injury Updates

Rams Injuries

49ers Injuries

Rams vs. 49ers Odds Comparison

Rams at 49ers Team Totals