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Chargers vs. 49ers Odds & Betting Predictions - August 24, 2025

Chargers at 49ers

12:30 am
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Los Angeles Chargers

2-0
@

San Francisco 49ers

0-1

Chargers at 49ers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Chargers
2-0
N/A
N/A
N/A
49ers
0-1
N/A
N/A
N/A
location pinSunday 12:30 a.m.
August 24, 2025
Levi's StadiumSanta Clara

Chargers vs. 49ers Props

Prop Projections

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Chargers vs. 49ers Public Betting Percentages

Away Logo

Chargers

Public

Home Logo

49ers

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • 49ers are 2-3 in their last 5 games.
  • 49ers are 2-3 in their last 5 games against the spread
  • 49ers are 1-7 in their road games against the spread
  • The totals have gone OVER in 2 of 49ers' last 5 games
  • The totals have gone OVER in 5 of 49ers' 9 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
49ers		5-124-51-75-80-4
Chargers		12-4-15-2-17-211-21-2-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
49ers		10-75-45-37-63-1
Chargers		8-95-33-67-61-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
49ers		6-11N/AN/A6-70-4
Chargers		11-6N/AN/A11-20-4

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Aug 10thDENL 9-30+6.5 LO 38.5DEN +240
Jan 5th@ARIL 24-47+5.5 LO 43.5ARI +195
Dec 31stDETL 34-40+4 LO 50.5DET +182
Dec 22nd@MIAL 17-29-1.5 LO 44MIA -125
Dec 13thLAL 6-12-3 LU 48.5LA -155

49ers vs. Chargers Injury Updates

49ers Injuries

  • Trevis Gipson
    LB

    Gipson is out with ankle

    Out

Chargers Injuries

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    Player Stats
    • passing yards
      Brock Purdy logo
      Brock Purdy
      3864
      pyds
    • passing touchdowns
      Brock Purdy logo
      Brock Purdy
      20
      ptd
    • rushing yards
      player logo
      -
      789
      ryds
    • rushing touchdowns
      Brock Purdy logo
      Brock Purdy
      5
      rtd
    Depth Charts
    Right Arrow
    Starter2ND3RD4TH
    QBBrock PurdyJoshua DobbsBrandon AllenTanner Mordecai
    RBChristian McCaffreyElijah MitchellJordan MasonPatrick Taylor
    WRJauan JenningsJacob CowingTrent Taylor
    TEGeorge KittleEric SaubertBrayden WillisJake Tonges
    LTJaylon MooreSebastian GutierrezIsaac Alarcon
    LGAaron BanksSpencer BurfordNick Zakelj
    CJake BrendelBen BartchDrake Nugent
    RGDominick PuniJon Feliciano
    RTColton McKivitz
    LDENick BosaRobert BealAlex BarrettJonathan Garvin
    LDTMaliek CollinsKevin Givens
    RDTJavon HargraveJordan ElliottKalia DavisEvan Anderson
    RDELeonard FloydYetur Gross-MatosSam Okuayinonu
    WLBDee Winters
    MLBFred WarnerCurtis RobinsonTatum Bethune
    SLBDe'Vondre CampbellDemetrius Flannigan-FowlesJalen Graham
    LCBCharvarius Ward
    SSMalik Mustapha
    FSJi'Ayir BrownGeorge OdumJaylen Mahoney
    RCBIsaac YiadomRock Ya-SinDarrell Luter
    PMitch Wishnowsky
    HMitch Wishnowsky
    PRTrent TaylorRicky Pearsall
    KRRicky PearsallTrent Taylor
    LSTaybor Pepper
    KJake Moody
    LWRBrandon AiyukRicky PearsallChris Conley
    NBDeommodore LenoirRenardo GreenChase Lucas
    FBKyle Juszczyk
    RWRDeebo Samuel

    Chargers vs. 49ers Odds Comparison

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    Chargers at 49ers Team Totals

    MatchupOverUnder
    Chargers
    2-0
    N/A
    N/A
    49ers
    0-1
    N/A
    N/A