| Lewis Cook | MID | Doubtful | Lewis Cook is Doubtful with Neck injury. | Cook is doubtful with neck | Dec 31 |
| Tyler Adams | MID | Out indefinitely | Hamstring | Hamstring | Apr 11 |
| Justin Kluivert | F | Out indefinitely | Knock | Knock | Feb 13 |
| Marcos Senesi | DEF | Out indefinitely | Knock | Knock | Sep 20 |
| Amine Adli | F | Out indefinitely | Neck Injury | Neck Injury | Oct 3 |
| Ben Doak | MID | Out | Ben Doak is expected to return Late February 2026 from Hamstring Injury. | Doak is out with hamstring | Dec 5 |
| Matai Akinmboni | DEF | Out indefinitely | None | Akinmboni is injured | Jan 4 |
| Declan Rice | MID | Out | Declan Rice is expected to return Early January 2026 from Knee injury. | Rice is out with knee | Dec 30 |
| Kai Havertz | F | Out indefinitely | Illness | Illness | Apr 3 |
| Martin Odegaard | MID | Out indefinitely | Virus | Virus | Jan 24 |
| Gabriel Magalhaes | DEF | Out indefinitely | Hamstring | Hamstring | May 17 |
| Christian Norgaard | MID | Out | Calf/Shin Injury | Calf/Shin Injury | Oct 29 |
| William Saliba | DEF | Out indefinitely | Back Injury | Back Injury | Apr 11 |
| Max Dowman | MID | Out | Max Dowman is expected to return Early February 2026 from Ankle injury. | Dowman is out with ankle | Dec 10 |
| Kristoffer Vassbakk Ajer | DEF | Out | Calf/Shin Injury | Calf/Shin Injury | Apr 11 |
| Mathias Jensen | MID | Out indefinitely | Knock | Knock | Aug 28 |
| Aaron Hickey | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 23 |
| Frank Onyeka | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Apr 8 |
| Fabio Carvalho | MID | Out for season | Fabio Carvalho is Out for season with Cruciate ligament injury. | Carvalho is out for season with knee | Dec 5 |
| Michael Kayode | DEF | Out | None | Kayode is out | Jan 25 |
| Joel Veltman | DEF | Out indefinitely | Thigh Muscle Rupture | Thigh Muscle Rupture | Jan 3 |
| Solly March | MID | Out indefinitely | None | March is injured | Aug 14 |
| Adam Webster | DEF | Out indefinitely | Webster, Adam: missing - injured | Webster is injured | Aug 22 |
| Georginio Rutter | F | Out indefinitely | Shoulder Injury | Shoulder Injury | Jul 11 |
| Diego Gomez | MID | Doubtful | None | Gomez is doubtful | Jan 3 |
| Yankuba Minteh | F | Out | Yankuba Minteh is expected to return Early January 2026 from Thigh injury. | Minteh is out with thigh | Dec 31 |
| Stefanos Tzimas | F | Out | Stefanos Tzimas is expected to return Early August 2026 from Cruciate ligament injury. | Tzimas is out with knee | Dec 22 |
| Kyle Walker | DEF | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Dec 6 |
| Joe Worrall | DEF | Out | Joe Worrall is expected to return Early January 2026 from Knock injury. | Worrall is out with knock injury | Dec 29 |
| Josh Cullen | MID | Doubtful | Josh Cullen is Doubtful with Knee injury. | Cullen is doubtful with knee | Dec 29 |
| S. Ojo | A | Out indefinitely | Knock | Knock | Feb 25 |
| G. Madine | A | Out indefinitely | Illness | Illness | Oct 28 |
| Romaine Theodore Sawyers | MID | Out | Suspended | Suspended | Mar 3 |
| J. Philogene | MID | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Feb 7 |
| Wesley Fofana | DEF | Out | Knock | Knock | Apr 4 |
| Mykhailo Mudryk | F | Out | None | Mudryk is out | Sep 2 |
| Marc Cucurella | DEF | Out | Suspended | Suspended | Mar 6 |
| Axel Disasi | DEF | Out | Suspended | Suspended | May 1 |
| Levi Colwill | DEF | Out indefinitely | None | Colwill is injured | Aug 16 |
| Romeo Lavia | MID | Out | Roméo Lavia is expected to return Early January 2026 from Thigh injury. | Lavia is out with thigh | Dec 5 |
| Ismaila Sarr | F | Doubtful | None | Sarr is doubtful | May 18 |
| Jean-Philippe Mateta | F | Out | Suspended | Suspended | May 17 |
| Borna Sosa | DEF | Out indefinitely | Knock | Knock | Feb 6 |
| Daichi Kamada | MID | Out indefinitely | Knock | Knock | Nov 11 |
| Will Hughes | MID | Doubtful | Will Hughes is Doubtful with Knock injury. | Hughes is doubtful with knock injury | Jan 1 |
| Chris Richards | DEF | Out | Knock | Knock | Apr 9 |
| Eddie Nketiah | F | Doubtful | Edward Nketiah is Doubtful with Strain injury. | Nketiah is doubtful with strain | Jan 1 |
| Naouirou Ahamada | MID | Out | Suspended | Suspended | Feb 5 |
| Daniel Munoz | DEF | Out | Daniel Muñoz is expected to return Mid December 2025 from Knee injury. | Munoz is out with knee | Dec 7 |
| Caleb Kporha | DEF | Out indefinitely | None | Kporha is injured | Aug 16 |
| Rio Cardines | F | Out | Rio Cardines is expected to return Mid January 2026 from Muscle injury. | Cardines is out with muscle | Dec 18 |
| Michael Keane | DEF | Out | Michael Keane is expected to return Mid January 2026 from Muscle injury. | Keane is out with muscle | Dec 30 |
| Seamus Coleman | DEF | Out | Seamus Coleman is expected to return Early January 2026 from Hamstring Injury. | Coleman is out with hamstring | Dec 22 |
| Jordan Pickford | GK | Out | Thigh Muscle Strain | Thigh Muscle Strain | Oct 1 |
| Kiernan Dewsbury-Hall | MID | Out | Kiernan Dewsbury-Hall is expected to return Mid January 2026 from Hamstring Injury. | Dewsbury-Hall is out with hamstring | Dec 19 |
| Vitaliy Mykolenko | DEF | Out | Calf/Shin Injury | Calf/Shin Injury | May 11 |
| Merlin Rohl | MID | Out | Merlin Röhl is expected to return Late December 2025 from Groin injury. | Rohl is out with groin | Dec 5 |
| Carlos Alcaraz | MID | Out | Carlos Alcaraz is expected to return Mid January 2026 from Muscle injury. | Alcaraz is out with muscle | Dec 31 |
| Bernd Leno | GK | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | Dec 20 |
| Issa Diop | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jul 4 |
| Sasa Lukic | MID | Out | Hamstring | Hamstring | Apr 17 |
| Kenny Tete | DEF | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Dec 27 |
| Timothy Castagne | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Mar 21 |
| Joachim Andersen | DEF | Out | Calf/Shin Injury | Calf/Shin Injury | Feb 11 |
| Ryan Sessegnon | MID | Day to day | Ryan Sessegnon is expected to return in A few days from Hamstring Injury. | Sessegnon is day-to-day with hamstring | Dec 22 |
| Rodrigo Muniz | F | Out | Rodrigo Muniz is expected to return Early February 2026 from Hamstring Injury. | Muniz is out with hamstring | Dec 22 |
| Y. Sanogo | A | Out | Shoulder Injury | Shoulder Injury | Feb 15 |
| M. Lowton | DEF | Out indefinitely | Knee Injury | Knee Injury | Oct 26 |
| Jason Puncheon | MID | Out indefinitely | PCL Knee Ligament Injury | PCL Knee Ligament Injury | May 28 |
| Fraizer Campbell | A | Out | Suspended | Suspended | Nov 18 |
| O. Niasse | A | Out | Suspended | Suspended | Nov 29 |
| A. King | MID | Out indefinitely | Hamstring | Hamstring | Aug 14 |
| Joel Castro | GK | Out indefinitely | Back Injury | Back Injury | Nov 21 |
| I. Mbenza | A | Out indefinitely | Knock | Knock | Feb 16 |
| A. Knockaert | MID | Out | Suspended | Suspended | Apr 7 |
| Michael Hefele | DEF | Out indefinitely | Cartilage Knee Injury | Cartilage Knee Injury | Aug 9 |
| Tom Smith | DEF | Out | Suspended | Suspended | Mar 9 |
| Jonathan Hogg | MID | Out | Suspended | Suspended | Jan 18 |
| C. Quaner | A | Out | Hamstring | Hamstring | Jan 20 |
| Daniel Williams | MID | Out | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Mar 30 |
| A. Pritchard | MID | Out indefinitely | Foot Injury | Foot Injury | Mar 12 |
| Pipa Ávila | DEF | Out indefinitely | Knock | Knock | Jul 17 |
| K. Ahearne-Grant | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 27 |
| Marc Pugh | MID | Out indefinitely | Hamstring | Hamstring | Sep 24 |
| Curtis Davies | DEF | Out indefinitely | Hamstring | Hamstring | Mar 7 |
| Brian Lenihan | DEF | Out indefinitely | Knee Injury | Knee Injury | Mar 7 |
| Moses Odubajo | DEF | Out | Knee Injury | Knee Injury | Mar 7 |
| Ryan Mason | MID | Out indefinitely | Head Injury | Head Injury | Mar 7 |
| David Meyler | MID | Out indefinitely | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Jun 8 |
| Sebastian Larsson | MID | Out | Suspended | Suspended | Feb 20 |
| Adama Noss Traoré | MID | Out | Medical Condition | Medical Condition | Feb 29 |
| Evandro Goebel | MID | Out | Groin Strain | Groin Strain | May 31 |
| D. Pelkas | MID | Out indefinitely | Foot Injury | Foot Injury | May 24 |
| O. Tufan | MID | Out indefinitely | Knock | Knock | Feb 18 |
| A. Connolly | A | Out | Chest Injury | Chest Injury | Apr 13 |
| J. Magennis | A | Out | Suspended | Suspended | Nov 24 |
| George Moncur | MID | Out | Suspended | Suspended | Aug 28 |
| Daniel James | F | Out | Daniel James is expected to return Late January 2026 from Hamstring Injury. | James is out with hamstring | Dec 5 |
| Karl Darlow | GK | Out | Ankle/Foot Injury | Ankle/Foot Injury | Nov 6 |
| Sean Longstaff | MID | Doubtful | Sean Longstaff is Doubtful with Calf injury. | Longstaff is doubtful with calf | Dec 30 |
| Joe Rodon | DEF | Out | Joe Rodon is expected to return Mid January 2026 from Ankle injury. | Rodon is out with ankle | Dec 29 |
| Joe Gelhardt | F | Doubtful | Joe Gelhardt is Doubtful with Calf injury. | Gelhardt is doubtful with calf | Dec 6 |
| Gabriel Gudmundsson | DEF | Out | Pubalgia | Pubalgia | Feb 9 |
| Joe Gomez | DEF | Out | Joe Gomez is expected to return Early January 2026 from Hamstring Injury. | Gomez is out with hamstring | Dec 22 |
| Alisson Alisson | GK | Out indefinitely | Virus | Virus | Jan 17 |
| Alexander Isak | F | Out indefinitely | Head Injury | Head Injury | Feb 13 |
| Ibrahima Konate | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Feb 21 |
| Jeremie Frimpong | DEF | Out | LCL Knee Ligament Injury | LCL Knee Ligament Injury | May 9 |
| Stefan Bajcetic | DEF | Out | Stefan Bajcetic is expected to return Early January 2026 from Hamstring Injury. | Bajcetic is out with hamstring | Dec 22 |
| John Stones | DEF | Out indefinitely | Hamstring | Hamstring | Mar 6 |
| Gianluigi Donnarumma | GK | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Feb 7 |
| Mateo Kovacic | MID | Out | Mateo Kovacic is expected to return Early January 2026 from Ankle injury. | Kovacic is out with ankle | Dec 5 |
| Rodri | MID | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Oct 6 |
| Erling Haaland | F | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Apr 10 |
| Rayan Ait-Nouri | DEF | Out indefinitely | Rayan Ait Nouri will not play due to National team. | Ait-Nouri is injured with unknown | Dec 17 |
| Oscar Bobb | MID | Out | Oscar Bobb is expected to return Early January 2026 from Muscle injury. | Bobb is out with muscle | Dec 19 |
| Harry Maguire | DEF | Out | Harry Maguire is expected to return Early January 2026 from Knock injury. | Maguire is out with knock injury | Dec 29 |
| Bruno Fernandes | MID | Out | Bruno Fernandes is expected to return Late January 2026 from Hamstring Injury. | Fernandes is out with hamstring | Dec 24 |
| Mason Mount | MID | Out | Mason Mount is expected to return Mid January 2026 from Muscle injury. | Mount is out with muscle | Dec 29 |
| Matheus Cunha | F | Out indefinitely | Hamstring | Hamstring | Sep 16 |
| Lisandro Martinez | DEF | Doubtful | None | Martinez is doubtful | May 11 |
| Kobbie Mainoo | MID | Out | Kobbie Mainoo is expected to return Early January 2026 from Calf injury. | Mainoo is out with calf | Dec 23 |
| Y. Bolasie | A | Out | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Mar 7 |
| Víctor Valdés Arribas | GK | Out indefinitely | Rib Injury | Rib Injury | May 15 |
| G. Leadbitter | MID | Out | Suspended | Suspended | Mar 10 |
| Paddy McNair | MID | Out | Suspended | Suspended | Dec 29 |
| D. Watmore | MID | Out | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Mar 7 |
| N. Taylor | DEF | Out | Hamstring | Hamstring | Jul 21 |
| M. Browne | MID | Out | Suspended | Suspended | Dec 29 |
| Z. Steffen | GK | Out indefinitely | Back Injury | Back Injury | Mar 14 |
| M. Johnson | MID | Out | Suspended | Suspended | Dec 7 |
| Kieran Trippier | DEF | Out | Ankle/Foot Injury | Ankle/Foot Injury | May 7 |
| Yoane Wissa | MID | Out indefinitely | Ankle Fracture | Ankle Fracture | Nov 29 |
| Emil Krafth | DEF | Out | Emil Krafth is expected to return Early January 2026 from Knee injury. | Krafth is out with knee | Dec 19 |
| Jamaal Lascelles | DEF | Doubtful | Jamaal Lascelles is Doubtful with Muscle injury. | Lascelles is doubtful with muscle | Dec 29 |
| Joelinton | F | Out | Suspended | Suspended | Mar 17 |
| Dan Burn | DEF | Out | Dan Burn is expected to return Mid January 2026 from Rib injury. | Burn is out with ribs | Dec 22 |
| Sven Botman | DEF | Out | Sven Botman is expected to return Mid December 2025 from Back injury. | Botman is out with back | Dec 6 |
| Bruno Guimaraes | MID | Out | Suspended | Suspended | Feb 26 |
| Tino Livramento | DEF | Out | Valentino Livramento is expected to return Mid January 2026 from Knee injury. | Livramento is out with knee | Dec 22 |
| Anthony Elanga | F | Doubtful | Anthony Elanga is Doubtful with Knock injury. | Elanga is doubtful with knock injury | Dec 29 |
| William Osula | F | Out | William Osula is expected to return Mid January 2026 from Ankle injury. | Osula is out with ankle | Dec 22 |
| Alex Murphy | DEF | Doubtful | None | Murphy is doubtful | Feb 16 |
| B. Gibson | DEF | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Jun 15 |
| D. Giannoulis | DEF | Out indefinitely | Back Injury | Back Injury | Sep 19 |
| I. Hayden | MID | Out indefinitely | Knee Injury | Knee Injury | May 19 |
| J. Sørensen | MID | Out | Knee Injury | Knee Injury | Mar 2 |
| S. Vokes | A | Out indefinitely | Abdominal Strain | Abdominal Strain | Nov 4 |
| P. Jagielka | DEF | Out | Suspended | Suspended | Mar 14 |
| Ashley Williams | DEF | Out indefinitely | Rib Injury | Rib Injury | Sep 28 |
| Glen Johnson | DEF | Out indefinitely | Knee Injury | Knee Injury | Feb 1 |
| R. Shawcross | DEF | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Jan 22 |
| Charlie Adam | MID | Out | Suspended | Suspended | Apr 16 |
| Stephen Ireland | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 2 |
| M. Diouf | A | Out indefinitely | Dislocated Shoulder | Dislocated Shoulder | Apr 2 |
| J. Ngoy | A | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Oct 16 |
| D. Gayle | A | Out | Knee Injury | Knee Injury | Dec 12 |
| B. Wilmot | DEF | Out indefinitely | Knee Injury | Knee Injury | Sep 3 |
| K. Hoever | DEF | Out | Thigh Muscle Rupture | Thigh Muscle Rupture | Apr 24 |
| Granit Xhaka | MID | Out | LCL Knee Ligament Injury | LCL Knee Ligament Injury | Dec 6 |
| Bertrand Traore | F | Out indefinitely | Bertrand Traore will not play due to National team. | Traore is injured with unknown | Dec 17 |
| Reinildo Mandava | DEF | Out indefinitely | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Apr 11 |
| Omar Alderete | DEF | Out | Suspended | Suspended | Mar 19 |
| Brian Brobbey | F | Out indefinitely | Knee Injury | Knee Injury | Mar 12 |
| Leo Fuhr Hjelde | DEF | Out | Knock | Knock | Oct 29 |
| Daniel Ballard | DEF | Doubtful | Daniel Ballard is Doubtful with Ankle injury. | Ballard is doubtful with ankle | Jan 1 |
| Arthur Masuaku | DEF | Out indefinitely | Arthur Masuaku will not play due to National team. | Masuaku is injured with unknown | Dec 17 |
| Sam Clucas | MID | Out | Suspended | Suspended | Mar 30 |
| Wilfried Guemiand Bony | A | Out indefinitely | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Jun 11 |
| Kyle Naughton | DEF | Out | Suspended | Suspended | Jan 6 |
| Àngel Rangel Zaragoza | DEF | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | May 14 |
| Leon Britton | MID | Out indefinitely | Groin Strain | Groin Strain | Mar 2 |
| Jack Cork | MID | Out | Ankle/Foot Injury | Ankle/Foot Injury | Dec 27 |
| Nathan Dyer | MID | Out indefinitely | Achilles tendonitis | Achilles tendonitis | Mar 7 |
| Wayne Routledge | MID | Out | Knock | Knock | Dec 27 |
| Oliver McBurnie | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jun 7 |
| K. Palmer | MID | Out indefinitely | Hamstring | Hamstring | Nov 20 |
| Cyrus Sylvester Frederick Christie | DEF | Out | Knock | Knock | Feb 9 |
| J. Bidwell | DEF | Out | Suspended | Suspended | Sep 30 |
| J. Piroe | A | Out indefinitely | Virus | Virus | Dec 7 |
| Dominic Solanke | F | Out | Dominic Solanke is expected to return Late January 2026 from Ankle injury. | Solanke is out with ankle | Dec 22 |
| Yves Bissouma | MID | Out indefinitely | Yves Bissouma will not play due to National team. | Bissouma is injured with unknown | Dec 17 |
| Joao Palhinha | MID | Out | Suspended | Suspended | Mar 12 |
| Cristian Romero | DEF | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Dec 6 |
| Dejan Kulusevski | MID | Out indefinitely | Hamstring | Hamstring | Nov 10 |
| Mohammed Kudus | MID | Out indefinitely | Knock | Knock | Feb 7 |
| Pape Matar Sarr | MID | Out indefinitely | Pape Sarr will not play due to National team. | Sarr is injured with unknown | Dec 17 |
| Micky Van de Ven | DEF | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | May 2 |
| Mathys Tel | F | Out indefinitely | Knock | Knock | Apr 11 |
| Dane Scarlett | F | Out indefinitely | None | Scarlett is injured | May 24 |
| Lucas Bergvall | MID | Doubtful | Lucas Bergvall is Doubtful with Groin injury. | Bergvall is doubtful with groin | Dec 30 |
| D. Gosling | MID | Out | Illness | Illness | Sep 11 |
| Tom Cleverley | MID | Out | Rib Injury | Rib Injury | May 22 |
| B. Hamer | GK | Out indefinitely | Knock | Knock | Jun 10 |
| Heurelho da Silva Gomes | GK | Out | Back Injury | Back Injury | Feb 24 |
| Miguel Ángel Britos Cabrera | DEF | Out indefinitely | Wisdom Teeth | Wisdom Teeth | Jun 5 |
| Craig Cathcart | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Sep 28 |
| J. Holebas | DEF | Out indefinitely | Foot Injury | Foot Injury | Jun 22 |
| Daryl Janmaat | DEF | Out indefinitely | Knee Injury | Knee Injury | Oct 15 |
| Christian Kabasele | DEF | Out | Knock | Knock | Jan 1 |
| Younes Kaboul | DEF | Out indefinitely | Metatarsal Fracture | Metatarsal Fracture | Sep 24 |
| T. Deeney | A | Out indefinitely | Knee Injury | Knee Injury | Nov 8 |
| Ben Foster | GK | Out | Groin/Pelvis Injury | Groin/Pelvis Injury | Jan 15 |
| G. Murray | A | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Feb 27 |
| H. Choudhury | MID | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | May 23 |
| R. Elliot | GK | Out indefinitely | Knock | Knock | Feb 24 |
| O. Etebo | MID | Out indefinitely | Knock | Knock | Jun 30 |
| K. Hause | DEF | Out indefinitely | Knee Injury | Knee Injury | Apr 11 |
| B. Sako | A | Out | Groin/Pelvis Injury | Groin/Pelvis Injury | Feb 14 |
| Jake Livermore | MID | Out | Suspended | Suspended | Dec 29 |
| Gareth McAuley | DEF | Out indefinitely | Illness | Illness | Feb 1 |
| James Morrison | MID | Out indefinitely | Achilles tendonitis | Achilles tendonitis | Jun 4 |
| Matt Phillips | MID | Out indefinitely | Virus | Virus | Jan 27 |
| Hal Robson-Kanu | MID | Out indefinitely | Arm/Elbow injury | Arm/Elbow injury | Jan 18 |
| G. Diangana | MID | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Feb 1 |
| A. Carroll | A | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Dec 14 |
| K. Bryan | DEF | Out | Calf/Shin Injury | Calf/Shin Injury | Dec 30 |
| Matheus Pereira | A | Out | Suspended | Suspended | Dec 27 |
| O. Yokuşlu | MID | Out indefinitely | Hamstring | Hamstring | Jan 3 |
| Kyle Bartley | DEF | Out | Calf/Shin Injury | Calf/Shin Injury | Jan 2 |
| K. Zohorè | A | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Oct 18 |
| Alphonse Areola | GK | Out indefinitely | Hamstring | Hamstring | Feb 20 |
| Lucas Paqueta | MID | Out indefinitely | Shoulder Injury | Shoulder Injury | Feb 27 |
| Crysencio Summerville | F | Out | Ankle/Foot Injury | Ankle/Foot Injury | Feb 6 |
| Tomas Soucek | MID | Out | Groin Strain | Groin Strain | Mar 8 |
| Hwang Hee-chan | F | Out | Knock | Knock | Apr 8 |
| Joergen Strand Larsen | F | Out indefinitely | None | Larsen is injured | Feb 13 |
| Jean-Ricner Bellegarde | MID | Out | Ankle/Foot Injury | Ankle/Foot Injury | Mar 19 |
| Toti Gomes | DEF | Out | Toti Gomes is expected to return Mid January 2026 from Hamstring Injury. | Gomes is out with hamstring | Dec 29 |
| Daniel Bentley | GK | Out | Daniel Bentley is expected to return Mid January 2026 from Ankle injury. | Bentley is out with ankle | Dec 22 |
| Leon Chiwome | F | Out indefinitely | None | Chiwome is injured | Aug 16 |
| Rodrigo Gomes | F | Out | Rodrigo Gomes is expected to return Early February 2026 from Groin injury. | Gomes is out with groin | Dec 5 |
Cardiff City
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